These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 31354221)

  • 1. Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase.
    Luo F; Li Y; Yuan F; Zuo J
    Chin J Cancer Res; 2019 Jun; 31(3):521-532. PubMed ID: 31354221
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Overexpression of Pyruvate Dehydrogenase E1α Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma.
    Sun J; Li J; Guo Z; Sun L; Juan C; Zhou Y; Gu H; Yu Y; Hu Q; Kan Q; Yu Z
    Oncol Res; 2019 Mar; 27(4):407-414. PubMed ID: 29444744
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.
    Fan J; Kang HB; Shan C; Elf S; Lin R; Xie J; Gu TL; Aguiar M; Lonning S; Chung TW; Arellano M; Khoury HJ; Shin DM; Khuri FR; Boggon TJ; Kang S; Chen J
    J Biol Chem; 2014 Sep; 289(38):26533-26541. PubMed ID: 25104357
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation.
    Jin Y; Cai Q; Shenoy AK; Lim S; Zhang Y; Charles S; Tarrash M; Fu X; Kamarajugadda S; Trevino JG; Tan M; Lu J
    Oncotarget; 2016 May; 7(18):25113-24. PubMed ID: 26848621
    [TBL] [Abstract][Full Text] [Related]  

  • 5. SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.
    Ozden O; Park SH; Wagner BA; Song HY; Zhu Y; Vassilopoulos A; Jung B; Buettner GR; Gius D
    Free Radic Biol Med; 2014 Nov; 76():163-172. PubMed ID: 25152236
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression.
    Ho N; Morrison J; Silva A; Coomber BL
    Biosci Rep; 2016 Jan; 36(1):e00299. PubMed ID: 26740252
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pyruvate dehydrogenase expression is negatively associated with cell stemness and worse clinical outcome in prostate cancers.
    Zhong Y; Li X; Ji Y; Li X; Li Y; Yu D; Yuan Y; Liu J; Li H; Zhang M; Ji Z; Fan D; Wen J; Goscinski MA; Yuan L; Hao B; Nesland JM; Suo Z
    Oncotarget; 2017 Feb; 8(8):13344-13356. PubMed ID: 28076853
    [TBL] [Abstract][Full Text] [Related]  

  • 8. p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer.
    Han CY; Patten DA; Lee SG; Parks RJ; Chan DW; Harper ME; Tsang BK
    Mol Carcinog; 2019 Nov; 58(11):2161-2174. PubMed ID: 31486135
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity.
    Kwak CH; Jin L; Han JH; Han CW; Kim E; Cho M; Chung TW; Bae SJ; Jang SB; Ha KT
    Int J Mol Sci; 2020 Aug; 21(17):. PubMed ID: 32825675
    [TBL] [Abstract][Full Text] [Related]  

  • 10.
    Liu L; Cao J; Zhao J; Li X; Suo Z; Li H
    Onco Targets Ther; 2019; 12():9899-9913. PubMed ID: 31819487
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
    Fan J; Shan C; Kang HB; Elf S; Xie J; Tucker M; Gu TL; Aguiar M; Lonning S; Chen H; Mohammadi M; Britton LM; Garcia BA; Alečković M; Kang Y; Kaluz S; Devi N; Van Meir EG; Hitosugi T; Seo JH; Lonial S; Gaddh M; Arellano M; Khoury HJ; Khuri FR; Boggon TJ; Kang S; Chen J
    Mol Cell; 2014 Feb; 53(4):534-48. PubMed ID: 24486017
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin.
    Hossain AJ; Islam R; Seo JB; Park HS; Kim JI; Kumar V; Lee KW; Park JB
    Int J Mol Sci; 2023 Sep; 24(18):. PubMed ID: 37761999
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines.
    Ahn KJ; Hwang HS; Park JH; Bang SH; Kang WJ; Yun M; Lee JD
    J Nucl Med; 2009 Sep; 50(9):1525-32. PubMed ID: 19690031
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth.
    Shan C; Kang HB; Elf S; Xie J; Gu TL; Aguiar M; Lonning S; Hitosugi T; Chung TW; Arellano M; Khoury HJ; Shin DM; Khuri FR; Boggon TJ; Fan J
    J Biol Chem; 2014 Aug; 289(31):21413-22. PubMed ID: 24962578
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy.
    Krasnov GS; Dmitriev AA; Lakunina VA; Kirpiy AA; Kudryavtseva AV
    Expert Opin Ther Targets; 2013 Oct; 17(10):1221-33. PubMed ID: 23984984
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II.
    Bryan N; Raisch KP
    Biosci Rep; 2015 Apr; 35(3):. PubMed ID: 26182367
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate.
    Chen Z; Zhang H; Lu W; Huang P
    Biochim Biophys Acta; 2009 May; 1787(5):553-60. PubMed ID: 19285479
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Subcellular localization of hexokinases I and II directs the metabolic fate of glucose.
    John S; Weiss JN; Ribalet B
    PLoS One; 2011 Mar; 6(3):e17674. PubMed ID: 21408025
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart.
    Nederlof R; Denis S; Lauzier B; Rosiers CD; Laakso M; Hagen J; Argmann C; Wanders R; Houtkooper RH; Hollmann MW; Houten SM; Zuurbier CJ
    Metabolism; 2017 Jul; 72():66-74. PubMed ID: 28641785
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Sirtuin 6 and metabolic genes interplay in Warburg effect in cancers.
    Al-Azzam N
    J Clin Biochem Nutr; 2020 May; 66(3):169-175. PubMed ID: 32523242
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.