128 related articles for article (PubMed ID: 31358465)
1. Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators.
Babkov DA; Zhukowskaya ON; Borisov AV; Babkova VA; Sokolova EV; Brigadirova AA; Litvinov RA; Kolodina AA; Morkovnik AS; Sochnev VS; Borodkin GS; Spasov AA
Bioorg Med Chem Lett; 2019 Sep; 29(17):2443-2447. PubMed ID: 31358465
[TBL] [Abstract][Full Text] [Related]
2. Discovery and evaluation of biphenyl derivatives of 2-iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity.
Babkov DA; Zhukovskaya ON; Brigadirova AA; Prilepskaya DR; Kolodina AA; Abbas AHS; Morkovnik AS; Sobhia ME; Ghosh K; Spasov AA
Chem Biol Drug Des; 2023 Apr; 101(4):896-914. PubMed ID: 36546307
[TBL] [Abstract][Full Text] [Related]
3. Antidiabetic and antiobesity effects of Ampkinone (6f), a novel small molecule activator of AMP-activated protein kinase.
Oh S; Kim SJ; Hwang JH; Lee HY; Ryu MJ; Park J; Kim SJ; Jo YS; Kim YK; Lee CH; Kweon KR; Shong M; Park SB
J Med Chem; 2010 Oct; 53(20):7405-13. PubMed ID: 20873794
[TBL] [Abstract][Full Text] [Related]
4. Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase.
Lan P; Romero FA; Wodka D; Kassick AJ; Dang Q; Gibson T; Cashion D; Zhou G; Chen Y; Zhang X; Zhang A; Li Y; Trujillo ME; Shao Q; Wu M; Xu S; He H; MacKenna D; Staunton J; Chapman KT; Weber A; Sebhat IK; Makara GM
J Med Chem; 2017 Nov; 60(21):9040-9052. PubMed ID: 29035567
[TBL] [Abstract][Full Text] [Related]
5. Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.
Chen XB; Zhuang JJ; Liu JH; Lei M; Ma L; Chen J; Shen X; Hu LH
Bioorg Med Chem; 2011 Oct; 19(19):5776-81. PubMed ID: 21893415
[TBL] [Abstract][Full Text] [Related]
6. Discovery of 3,5-Dimethylpyridin-4(1H)-one Derivatives as Activators of AMP-Activated Protein Kinase (AMPK).
Kuramoto K; Sawada Y; Ishibashi N; Yamada T; Nagashima T; Shin T
Chem Pharm Bull (Tokyo); 2020; 68(1):77-90. PubMed ID: 31902903
[TBL] [Abstract][Full Text] [Related]
7. (WO2011057959) indole and indazole derivatives as glycogen synthase activators: a patent evaluation.
Skaltsounis AL; Gaboriaud-Kolar N
Expert Opin Ther Pat; 2011 Dec; 21(12):1925-9. PubMed ID: 21988345
[TBL] [Abstract][Full Text] [Related]
8. Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus.
Francini F; Schinella GR; Ríos JL
Mini Rev Med Chem; 2019; 19(11):880-901. PubMed ID: 30484403
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators.
Wang J; Liu J; Xie Z; Li J; Li J; Hu L
Bioorg Med Chem Lett; 2020 Jan; 30(2):126790. PubMed ID: 31744674
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes.
Zhou S; Duan Y; Wang J; Zhang J; Sun H; Jiang H; Gu Z; Tong J; Li J; Li J; Liu H
Eur J Med Chem; 2017 Nov; 140():448-464. PubMed ID: 28987606
[TBL] [Abstract][Full Text] [Related]
11. In silico Analysis of AMP-activated Protein Kinase and Ligand-based Virtual Screening for Identification of Novel AMPK Activators.
Ghaffar A; Batool S; Mushtaq G; Kamal MA
Curr Comput Aided Drug Des; 2017; 13(3):222-233. PubMed ID: 28294049
[TBL] [Abstract][Full Text] [Related]
12. Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.
Musi N; Goodyear LJ
Curr Drug Targets Immune Endocr Metabol Disord; 2002 Jul; 2(2):119-27. PubMed ID: 12476786
[TBL] [Abstract][Full Text] [Related]
13. Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Xu J; Lin S; Myers RW; Addona G; Berger JP; Campbell B; Chen HS; Chen Z; Eiermann GJ; Elowe NH; Farrer BT; Feng W; Fu Q; Kats-Kagan R; Kavana M; Malkani S; McMasters DR; Mitra K; Pachanski MJ; Tong X; Trujillo ME; Xu L; Zhang B; Zhang F; Zhang R; Parmee ER
Bioorg Med Chem Lett; 2017 May; 27(9):2069-2073. PubMed ID: 28284804
[TBL] [Abstract][Full Text] [Related]
14. Discovery, synthesis, and structure-activity relationships of 20(S)-protopanaxadiol (PPD) derivatives as a novel class of AMPKα2β1γ1 activators.
Liu J; Chen D; Liu P; He M; Li J; Li J; Hu L
Eur J Med Chem; 2014 May; 79():340-9. PubMed ID: 24747289
[TBL] [Abstract][Full Text] [Related]
15. Identification of novel benzimidazole derivatives as highly potent AMPK activators with anti-diabetic profiles.
Tamura Y; Morita I; Hinata Y; Kojima E; Sasaki Y; Wada T; Asano M; Fujioka M; Hayasaki-Kajiwara Y; Iwasaki T; Matsumura K
Bioorg Med Chem Lett; 2023 Jan; 79():129059. PubMed ID: 36402454
[TBL] [Abstract][Full Text] [Related]
16. Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice.
Zhang M; Xie ZF; Zhang RT; Chen DK; Gu M; Cui SC; Zhang YM; Zhang XW; Yu YY; Li J; Nan FJ; Li JY
Acta Pharmacol Sin; 2018 Oct; 39(10):1622-1632. PubMed ID: 29795358
[TBL] [Abstract][Full Text] [Related]
17. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Cokorinos EC; Delmore J; Reyes AR; Albuquerque B; Kjøbsted R; Jørgensen NO; Tran JL; Jatkar A; Cialdea K; Esquejo RM; Meissen J; Calabrese MF; Cordes J; Moccia R; Tess D; Salatto CT; Coskran TM; Opsahl AC; Flynn D; Blatnik M; Li W; Kindt E; Foretz M; Viollet B; Ward J; Kurumbail RG; Kalgutkar AS; Wojtaszewski JFP; Cameron KO; Miller RA
Cell Metab; 2017 May; 25(5):1147-1159.e10. PubMed ID: 28467931
[TBL] [Abstract][Full Text] [Related]
18. Development of novel adenosine monophosphate-activated protein kinase activators.
Guh JH; Chang WL; Yang J; Lee SL; Wei S; Wang D; Kulp SK; Chen CS
J Med Chem; 2010 Mar; 53(6):2552-61. PubMed ID: 20170185
[TBL] [Abstract][Full Text] [Related]
19. Discovery of natural adenosine monophosphate‑activated protein kinase activators through virtual screening and activity verification studies.
Hao J; Yang Z; Li J; Han L; Zhang Y; Wang T
Mol Med Rep; 2021 Mar; 23(3):. PubMed ID: 33495803
[TBL] [Abstract][Full Text] [Related]
20. Derivatives of benzimidazole pharmacophore: synthesis, anticonvulsant, antidiabetic and DNA cleavage studies.
Shingalapur RV; Hosamani KM; Keri RS; Hugar MH
Eur J Med Chem; 2010 May; 45(5):1753-9. PubMed ID: 20122763
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
