358 related articles for article (PubMed ID: 31371421)
1. Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1).
Sajid A; Raju N; Lusvarghi S; Vahedi S; Swenson RE; Ambudkar SV
Drug Metab Dispos; 2019 Oct; 47(10):1013-1023. PubMed ID: 31371421
[TBL] [Abstract][Full Text] [Related]
2. Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency.
Vahedi S; Chufan EE; Ambudkar SV
Biochem Pharmacol; 2017 Nov; 143():53-64. PubMed ID: 28728917
[TBL] [Abstract][Full Text] [Related]
3. Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).
Pluchino KM; Hall MD; Moen JK; Chufan EE; Fetsch PA; Shukla S; Gill DR; Hyde SC; Xia D; Ambudkar SV; Gottesman MM
Biochemistry; 2016 Feb; 55(7):1010-23. PubMed ID: 26820614
[TBL] [Abstract][Full Text] [Related]
4. Evidence for the Interaction of A
Abel B; Tosh DK; Durell SR; Murakami M; Vahedi S; Jacobson KA; Ambudkar SV
Mol Pharmacol; 2019 Aug; 96(2):180-192. PubMed ID: 31127007
[TBL] [Abstract][Full Text] [Related]
5. Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1).
Sajid A; Lusvarghi S; Chufan EE; Ambudkar SV
PLoS One; 2018; 13(9):e0204693. PubMed ID: 30265721
[TBL] [Abstract][Full Text] [Related]
6. Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
Chufan EE; Kapoor K; Ambudkar SV
Biochem Pharmacol; 2016 Feb; 101():40-53. PubMed ID: 26686578
[TBL] [Abstract][Full Text] [Related]
7. Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.
Li MJ; Nath A; Atkins WM
Biochemistry; 2017 May; 56(19):2506-2517. PubMed ID: 28441502
[TBL] [Abstract][Full Text] [Related]
8. Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.
Limtrakul P; Chearwae W; Shukla S; Phisalphong C; Ambudkar SV
Mol Cell Biochem; 2007 Feb; 296(1-2):85-95. PubMed ID: 16960658
[TBL] [Abstract][Full Text] [Related]
9. Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference.
Ansbro MR; Shukla S; Ambudkar SV; Yuspa SH; Li L
PLoS One; 2013; 8(4):e60334. PubMed ID: 23593196
[TBL] [Abstract][Full Text] [Related]
10. Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters.
Fan YF; Zhang W; Zeng L; Lei ZN; Cai CY; Gupta P; Yang DH; Cui Q; Qin ZD; Chen ZS; Trombetta LD
Cancer Lett; 2018 May; 421():186-198. PubMed ID: 29331420
[TBL] [Abstract][Full Text] [Related]
11. Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo.
De Vera AA; Gupta P; Lei Z; Liao D; Narayanan S; Teng Q; Reznik SE; Chen ZS
Cancer Lett; 2019 Feb; 442():91-103. PubMed ID: 30391357
[TBL] [Abstract][Full Text] [Related]
12. Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells.
Cui Q; Cai CY; Wang JQ; Zhang S; Gupta P; Ji N; Yang Y; Dong X; Yang DH; Chen ZS
Int J Mol Sci; 2019 Aug; 20(17):. PubMed ID: 31443367
[TBL] [Abstract][Full Text] [Related]
13. Detection of P-glycoprotein expression by tumoral cells with NBDL-CsA, a fluorescent derivative of cyclosporin A.
Didier A; Tiberghien F; Wenger R; Loor F
Anticancer Drugs; 1996 May; 7(3):257-65. PubMed ID: 8791998
[TBL] [Abstract][Full Text] [Related]
14. Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.
Watanabe T; Uchiyama N; Roninson IB; Cohen D; Atadja P
Int J Oncol; 2000 Sep; 17(3):579-86. PubMed ID: 10938401
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.
Shukla S; Skoumbourdis AP; Walsh MJ; Hartz AM; Fung KL; Wu CP; Gottesman MM; Bauer B; Thomas CJ; Ambudkar SV
Mol Pharm; 2011 Aug; 8(4):1292-302. PubMed ID: 21630681
[TBL] [Abstract][Full Text] [Related]
16. Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance.
Mitani Y; Satake K; Tsukamoto M; Nakamura I; Kadioglu O; Teruya T; Yonezawa T; Cha BY; Efferth T; Woo JT; Nakagawa H
Phytomedicine; 2018 Dec; 51():112-119. PubMed ID: 30466608
[TBL] [Abstract][Full Text] [Related]
17. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Lee TD; Lee OW; Brimacombe KR; Chen L; Guha R; Lusvarghi S; Tebase BG; Klumpp-Thomas C; Robey RW; Ambudkar SV; Shen M; Gottesman MM; Hall MD
Mol Pharmacol; 2019 Nov; 96(5):629-640. PubMed ID: 31515284
[TBL] [Abstract][Full Text] [Related]
18. Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70.
Kapoor K; Bhatnagar J; Chufan EE; Ambudkar SV
J Biol Chem; 2013 Nov; 288(45):32622-32636. PubMed ID: 24064216
[TBL] [Abstract][Full Text] [Related]
19. Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes.
To KKW; Wu X; Yin C; Chai S; Yao S; Kadioglu O; Efferth T; Ye Y; Lin G
J Ethnopharmacol; 2017 May; 203():110-119. PubMed ID: 28363522
[TBL] [Abstract][Full Text] [Related]
20. Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies.
Mora Lagares L; Minovski N; Caballero Alfonso AY; Benfenati E; Wellens S; Culot M; Gosselet F; Novič M
Int J Mol Sci; 2020 Jun; 21(11):. PubMed ID: 32517082
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
