188 related articles for article (PubMed ID: 31377316)
1. Mitochondrial MTHFD isozymes display distinct expression, regulation, and association with cancer.
Nilsson R; Nicolaidou V; Koufaris C
Gene; 2019 Oct; 716():144032. PubMed ID: 31377316
[TBL] [Abstract][Full Text] [Related]
2. Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues.
Shin M; Bryant JD; Momb J; Appling DR
J Biol Chem; 2014 May; 289(22):15507-17. PubMed ID: 24733394
[TBL] [Abstract][Full Text] [Related]
3. Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.
Ju HQ; Lu YX; Chen DL; Zuo ZX; Liu ZX; Wu QN; Mo HY; Wang ZX; Wang DS; Pu HY; Zeng ZL; Li B; Xie D; Huang P; Hung MC; Chiao PJ; Xu RH
J Natl Cancer Inst; 2019 Jun; 111(6):584-596. PubMed ID: 30534944
[TBL] [Abstract][Full Text] [Related]
4. Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signaling.
Cui X; Su H; Yang J; Wu X; Huo K; Jing X; Zhang S
J Ovarian Res; 2022 Feb; 15(1):23. PubMed ID: 35135596
[TBL] [Abstract][Full Text] [Related]
5. p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage.
Li G; Wu J; Li L; Jiang P
Proc Natl Acad Sci U S A; 2021 Jul; 118(28):. PubMed ID: 34244426
[TBL] [Abstract][Full Text] [Related]
6. The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.
Scaletti ER; Gustafsson Westergren R; Andersson Y; Wiita E; Henriksson M; Homan EJ; Jemth AS; Helleday T; Stenmark P
ChemMedChem; 2022 Sep; 17(18):e202200274. PubMed ID: 35712863
[TBL] [Abstract][Full Text] [Related]
7. MTHFD2 Overexpression Predicts Poor Prognosis in Renal Cell Carcinoma and is Associated with Cell Proliferation and Vimentin-Modulated Migration and Invasion.
Lin H; Huang B; Wang H; Liu X; Hong Y; Qiu S; Zheng J
Cell Physiol Biochem; 2018; 51(2):991-1000. PubMed ID: 30466107
[TBL] [Abstract][Full Text] [Related]
8. MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions.
Mo HY; Wang RB; Ma MY; Zhang Y; Li XY; Wen WR; Han Y; Tian T
Redox Rep; 2024 Dec; 29(1):2345455. PubMed ID: 38723197
[TBL] [Abstract][Full Text] [Related]
9. Down-regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle-related genes.
Yu C; Yang L; Cai M; Zhou F; Xiao S; Li Y; Wan T; Cheng D; Wang L; Zhao C; Huang X
J Cell Mol Med; 2020 Jan; 24(2):1568-1577. PubMed ID: 31778025
[TBL] [Abstract][Full Text] [Related]
10. Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell.
Wan X; Wang C; Huang Z; Zhou D; Xiang S; Qi Q; Chen X; Arbely E; Liu CY; Du P; Yu W
Cell Death Dis; 2020 Aug; 11(8):649. PubMed ID: 32811824
[TBL] [Abstract][Full Text] [Related]
11. MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK-3β/β-catenin signalling.
Shi Y; Xu Y; Yao J; Yan C; Su H; Zhang X; Chen E; Ying K
J Cell Mol Med; 2021 Jul; 25(14):7013-7027. PubMed ID: 34121323
[TBL] [Abstract][Full Text] [Related]
12. Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy.
Cheung CHY; Hsu CL; Tsuei CY; Kuo TT; Huang CT; Hsu WM; Chung YH; Wu HY; Hsu CC; Huang HC; Juan HF
Cell Death Dis; 2019 Oct; 10(11):786. PubMed ID: 31624245
[TBL] [Abstract][Full Text] [Related]
13. Detection and characterisation of novel alternative splicing variants of the mitochondrial folate enzyme MTHFD2.
Nicolaidou V; Papaneophytou C; Koufaris C
Mol Biol Rep; 2020 Sep; 47(9):7089-7096. PubMed ID: 32880830
[TBL] [Abstract][Full Text] [Related]
14. Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2).
Lee LC; Peng YH; Chang HH; Hsu T; Lu CT; Huang CH; Hsueh CC; Kung FC; Kuo CC; Jiaang WT; Wu SY
J Med Chem; 2021 Aug; 64(15):11288-11301. PubMed ID: 34337952
[TBL] [Abstract][Full Text] [Related]
15. Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Nishimura T; Nakata A; Chen X; Nishi K; Meguro-Horike M; Sasaki S; Kita K; Horike SI; Saitoh K; Kato K; Igarashi K; Murayama T; Kohno S; Takahashi C; Mukaida N; Yano S; Soga T; Tojo A; Gotoh N
Oncogene; 2019 Apr; 38(14):2464-2481. PubMed ID: 30532069
[TBL] [Abstract][Full Text] [Related]
16. Non-metabolic function of MTHFD2 activates CDK2 in bladder cancer.
Liu X; Liu S; Piao C; Zhang Z; Zhang X; Jiang Y; Kong C
Cancer Sci; 2021 Dec; 112(12):4909-4919. PubMed ID: 34632667
[TBL] [Abstract][Full Text] [Related]
17. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.
Nilsson R; Jain M; Madhusudhan N; Sheppard NG; Strittmatter L; Kampf C; Huang J; Asplund A; Mootha VK
Nat Commun; 2014; 5():3128. PubMed ID: 24451681
[TBL] [Abstract][Full Text] [Related]
18. MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway.
Li Q; Yang F; Shi X; Bian S; Shen F; Wu Y; Zhu C; Fu F; Wang J; Zhou J; Chen Y
FEBS Open Bio; 2021 Oct; 11(10):2845-2857. PubMed ID: 34231329
[TBL] [Abstract][Full Text] [Related]
19. Glioma cells require one-carbon metabolism to survive glutamine starvation.
Tanaka K; Sasayama T; Nagashima H; Irino Y; Takahashi M; Izumi Y; Uno T; Satoh N; Kitta A; Kyotani K; Fujita Y; Hashiguchi M; Nakai T; Kohta M; Uozumi Y; Shinohara M; Hosoda K; Bamba T; Kohmura E
Acta Neuropathol Commun; 2021 Jan; 9(1):16. PubMed ID: 33468252
[TBL] [Abstract][Full Text] [Related]
20. Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase.
Shin M; Momb J; Appling DR
Cancer Metab; 2017; 5():11. PubMed ID: 29225823
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]