These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury. Pelisch N; Rosas Almanza J; Stehlik KE; Aperi BV; Kroner A eNeuro; 2021; 8(2):. PubMed ID: 33632814 [TBL] [Abstract][Full Text] [Related]
5. Characterization of antisense oligonucleotides comprising 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA): specificity, potency, and duration of activity. Ferrari N; Bergeron D; Tedeschi AL; Mangos MM; Paquet L; Renzi PM; Damha MJ Ann N Y Acad Sci; 2006 Oct; 1082():91-102. PubMed ID: 17145930 [TBL] [Abstract][Full Text] [Related]
6. RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus. Liang XH; Sun H; Nichols JG; Crooke ST Mol Ther; 2017 Sep; 25(9):2075-2092. PubMed ID: 28663102 [TBL] [Abstract][Full Text] [Related]
7. NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides. Zhang L; Bernardo KD; Vickers TA; Tian J; Liang XH; Crooke ST Nucleic Acid Ther; 2022 Aug; 32(4):280-299. PubMed ID: 35852833 [TBL] [Abstract][Full Text] [Related]
8. Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides. Østergaard ME; De Hoyos CL; Wan WB; Shen W; Low A; Berdeja A; Vasquez G; Murray S; Migawa MT; Liang XH; Swayze EE; Crooke ST; Seth PP Nucleic Acids Res; 2020 Feb; 48(4):1691-1700. PubMed ID: 31980820 [TBL] [Abstract][Full Text] [Related]
9. Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins. Zhang L; Vickers TA; Sun H; Liang XH; Crooke ST Nucleic Acids Res; 2021 Mar; 49(5):2721-2739. PubMed ID: 33577678 [TBL] [Abstract][Full Text] [Related]
10. RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides. Hori SI; Mitsuoka Y; Kugimiya A Nucleic Acid Ther; 2019 Feb; 29(1):44-50. PubMed ID: 30508397 [TBL] [Abstract][Full Text] [Related]
11. Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms. Vickers TA; Crooke ST PLoS One; 2014; 9(10):e108625. PubMed ID: 25299183 [TBL] [Abstract][Full Text] [Related]
13. A single-cell map of antisense oligonucleotide activity in the brain. Mortberg MA; Gentile JE; Nadaf NM; Vanderburg C; Simmons S; Dubinsky D; Slamin A; Maldonado S; Petersen CL; Jones N; Kordasiewicz HB; Zhao HT; Vallabh SM; Minikel EV Nucleic Acids Res; 2023 Aug; 51(14):7109-7124. PubMed ID: 37188501 [TBL] [Abstract][Full Text] [Related]
14. Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts. Burel SA; Hart CE; Cauntay P; Hsiao J; Machemer T; Katz M; Watt A; Bui HH; Younis H; Sabripour M; Freier SM; Hung G; Dan A; Prakash TP; Seth PP; Swayze EE; Bennett CF; Crooke ST; Henry SP Nucleic Acids Res; 2016 Mar; 44(5):2093-109. PubMed ID: 26553810 [TBL] [Abstract][Full Text] [Related]
15. Advancing the enzymatic toolkit for 2'-fluoro arabino nucleic acid (FANA) manipulation: phosphorylation, ligation, replication, and templating RNA transcription. Liu Y; Wang J; Wu Y; Wang Y Chem Sci; 2024 Aug; 15(31):12534-12542. PubMed ID: 39118620 [TBL] [Abstract][Full Text] [Related]
16. Effects of combinations of gapmer antisense oligonucleotides on the target reduction. Yanagidaira M; Yoshioka K; Nagata T; Nakao S; Miyata K; Yokota T Mol Biol Rep; 2023 Apr; 50(4):3539-3546. PubMed ID: 36787053 [TBL] [Abstract][Full Text] [Related]
17. The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA. Vickers TA; Crooke ST Nucleic Acids Res; 2015 Oct; 43(18):8955-63. PubMed ID: 26384424 [TBL] [Abstract][Full Text] [Related]