These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
303 related articles for article (PubMed ID: 31399555)
1. CDK7 inhibitor THZ1 inhibits MCL1 synthesis and drives cholangiocarcinoma apoptosis in combination with BCL2/BCL-XL inhibitor ABT-263. Huang T; Ding X; Xu G; Chen G; Cao Y; Peng C; Shen S; Lv Y; Wang L; Zou X Cell Death Dis; 2019 Aug; 10(8):602. PubMed ID: 31399555 [TBL] [Abstract][Full Text] [Related]
2. The Covalent CDK7 Inhibitor THZ1 Potently Induces Apoptosis in Multiple Myeloma Cells Zhang Y; Zhou L; Bandyopadhyay D; Sharma K; Allen AJ; Kmieciak M; Grant S Clin Cancer Res; 2019 Oct; 25(20):6195-6205. PubMed ID: 31358538 [TBL] [Abstract][Full Text] [Related]
3. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Cayrol F; Praditsuktavorn P; Fernando TM; Kwiatkowski N; Marullo R; Calvo-Vidal MN; Phillip J; Pera B; Yang SN; Takpradit K; Roman L; Gaudiano M; Crescenzo R; Ruan J; Inghirami G; Zhang T; Cremaschi G; Gray NS; Cerchietti L Nat Commun; 2017 Jan; 8():14290. PubMed ID: 28134252 [TBL] [Abstract][Full Text] [Related]
4. Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer. Li B; Ni Chonghaile T; Fan Y; Madden SF; Klinger R; O'Connor AE; Walsh L; O'Hurley G; Mallya Udupi G; Joseph J; Tarrant F; Conroy E; Gaber A; Chin SF; Bardwell HA; Provenzano E; Crown J; Dubois T; Linn S; Jirstrom K; Caldas C; O'Connor DP; Gallagher WM Cancer Res; 2017 Jul; 77(14):3834-3845. PubMed ID: 28455421 [TBL] [Abstract][Full Text] [Related]
5. CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer. Wang J; Zhang R; Lin Z; Zhang S; Chen Y; Tang J; Hong J; Zhou X; Zong Y; Xu Y; Meng R; Xu S; Liu L; Zhang T; Yang K; Dong X; Wu G J Hematol Oncol; 2020 Jul; 13(1):99. PubMed ID: 32690037 [TBL] [Abstract][Full Text] [Related]
6. THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours. Sun J; Zhang Q; Sun X; Xue A; Gao X; Shen K Cell Commun Signal; 2022 Sep; 20(1):138. PubMed ID: 36076237 [TBL] [Abstract][Full Text] [Related]
7. Inhibition of cyclin-dependent kinase 7 suppresses human hepatocellular carcinoma by inducing apoptosis. Zhong L; Yang S; Jia Y; Lei K J Cell Biochem; 2018 Dec; 119(12):9742-9751. PubMed ID: 30145799 [TBL] [Abstract][Full Text] [Related]
8. Nanomaterial-Facilitated Cyclin-Dependent Kinase 7 Inhibition Suppresses Gallbladder Cancer Progression via Targeting Transcriptional Addiction. Huang CS; Xu QC; Dai C; Wang L; Tien YC; Li F; Su Q; Huang XT; Wu J; Zhao W; Yin XY ACS Nano; 2021 Sep; 15(9):14744-14755. PubMed ID: 34405985 [TBL] [Abstract][Full Text] [Related]
9. CDK7 blockade suppresses super-enhancer-associated oncogenes in bladder cancer. Yang Y; Jiang D; Zhou Z; Xiong H; Yang X; Peng G; Xia W; Wang S; Lei H; Zhao J; Qian Z; Wu S; Pang J Cell Oncol (Dordr); 2021 Aug; 44(4):871-887. PubMed ID: 33905040 [TBL] [Abstract][Full Text] [Related]
10. THZ1 reveals CDK7-dependent transcriptional addictions in pancreatic cancer. Lu P; Geng J; Zhang L; Wang Y; Niu N; Fang Y; Liu F; Shi J; Zhang ZG; Sun YW; Wang LW; Tang Y; Xue J Oncogene; 2019 May; 38(20):3932-3945. PubMed ID: 30692639 [TBL] [Abstract][Full Text] [Related]
11. Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Klanova M; Andera L; Brazina J; Svadlenka J; Benesova S; Soukup J; Prukova D; Vejmelkova D; Jaksa R; Helman K; Vockova P; Lateckova L; Molinsky J; Maswabi BC; Alam M; Kodet R; Pytlik R; Trneny M; Klener P Clin Cancer Res; 2016 Mar; 22(5):1138-49. PubMed ID: 26467384 [TBL] [Abstract][Full Text] [Related]
12. Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN-amplified neuroblastoma. Tee AE; Ciampa OC; Wong M; Fletcher JI; Kamili A; Chen J; Ho N; Sun Y; Carter DR; Cheung BB; Marshall GM; Liu PY; Liu T Int J Cancer; 2020 Oct; 147(7):1928-1938. PubMed ID: 32086952 [TBL] [Abstract][Full Text] [Related]
13. Pharmacological inhibition of CDK7 by THZ1 impairs tumor growth in p53-mutated HNSCC. Ge H; Yao Y; Jiang Y; Wu X; Wang Y Oral Dis; 2022 Apr; 28(3):611-620. PubMed ID: 33503275 [TBL] [Abstract][Full Text] [Related]
14. CDK7 inhibition by THZ1 suppresses cancer stemness in both chemonaïve and chemoresistant urothelial carcinoma via the hedgehog signaling pathway. Chow PM; Chang YW; Kuo KL; Lin WC; Liu SH; Huang KH Cancer Lett; 2021 Jun; 507():70-79. PubMed ID: 33741425 [TBL] [Abstract][Full Text] [Related]
15. CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition. McDermott MSJ; Sharko AC; Munie J; Kassler S; Melendez T; Lim CU; Broude EV Cells; 2020 Mar; 9(3):. PubMed ID: 32155786 [TBL] [Abstract][Full Text] [Related]
16. Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation. Juric V; Hudson L; Fay J; Richards CE; Jahns H; Verreault M; Bielle F; Idbaih A; Lamfers MLM; Hopkins AM; Rehm M; Murphy BM Cell Death Dis; 2021 Aug; 12(8):763. PubMed ID: 34344865 [TBL] [Abstract][Full Text] [Related]
17. CDK7 inhibition as a promising therapeutic strategy for lung squamous cell carcinomas with a SOX2 amplification. Hur JY; Kim HR; Lee JY; Park S; Hwang JA; Kim WS; Yoon S; Choi CM; Rho JK; Lee JC Cell Oncol (Dordr); 2019 Aug; 42(4):449-458. PubMed ID: 30838525 [TBL] [Abstract][Full Text] [Related]
18. CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists. Liu F; Jiang W; Sui Y; Meng W; Hou L; Li T; Li M; Zhang L; Mo J; Wang J; Zhao Y; Zhang L; Ma J; Tang Y Proc Natl Acad Sci U S A; 2019 Jun; 116(26):12986-12995. PubMed ID: 31182587 [TBL] [Abstract][Full Text] [Related]
19. Combinational therapeutic targeting of BRD4 and CDK7 synergistically induces anticancer effects in head and neck squamous cell carcinoma. Zhang W; Ge H; Jiang Y; Huang R; Wu Y; Wang D; Guo S; Li S; Wang Y; Jiang H; Cheng J Cancer Lett; 2020 Jan; 469():510-523. PubMed ID: 31765738 [TBL] [Abstract][Full Text] [Related]
20. Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers. Sun B; Mason S; Wilson RC; Hazard SE; Wang Y; Fang R; Wang Q; Yeh ES; Yang M; Roberts TM; Zhao JJ; Wang Q Oncogene; 2020 Jan; 39(1):50-63. PubMed ID: 31462705 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]