BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

291 related articles for article (PubMed ID: 31399555)

  • 21. The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes.
    Sampathi S; Acharya P; Zhao Y; Wang J; Stengel KR; Liu Q; Savona MR; Hiebert SW
    Nucleic Acids Res; 2019 May; 47(8):3921-3936. PubMed ID: 30805632
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells.
    Wang B; Ni Z; Dai X; Qin L; Li X; Xu L; Lian J; He F
    Mol Cancer; 2014 Apr; 13():98. PubMed ID: 24779770
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The covalent CDK7 inhibitor THZ1 enhances temsirolimus-induced cytotoxicity via autophagy suppression in human renal cell carcinoma.
    Chow PM; Liu SH; Chang YW; Kuo KL; Lin WC; Huang KH
    Cancer Lett; 2020 Feb; 471():27-37. PubMed ID: 31812697
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1.
    Li L; Pongtornpipat P; Tiutan T; Kendrick SL; Park S; Persky DO; Rimsza LM; Puvvada SD; Schatz JH
    Leukemia; 2015 Aug; 29(8):1702-12. PubMed ID: 25882699
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Key Survival Factor, Mcl-1, Correlates with Sensitivity to Combined Bcl-2/Bcl-xL Blockade.
    Williams MM; Lee L; Hicks DJ; Joly MM; Elion D; Rahman B; McKernan C; Sanchez V; Balko JM; Stricker T; Estrada MV; Cook RS
    Mol Cancer Res; 2017 Mar; 15(3):259-268. PubMed ID: 28039357
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma.
    Chen HD; Huang CS; Xu QC; Li F; Huang XT; Wang JQ; Li SJ; Zhao W; Yin XY
    Int J Biol Sci; 2020; 16(7):1207-1217. PubMed ID: 32174795
    [TBL] [Abstract][Full Text] [Related]  

  • 27. THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism.
    Cheng ZJ; Miao DL; Su QY; Tang XL; Wang XL; Deng LB; Shi HD; Xin HB
    Acta Pharmacol Sin; 2019 Jun; 40(6):814-822. PubMed ID: 30446732
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma.
    Cao X; Dang L; Zheng X; Lu Y; Lu Y; Ji R; Zhang T; Ruan X; Zhi J; Hou X; Yi X; Li MJ; Gu T; Gao M; Zhang L; Chen Y
    Thyroid; 2019 Jun; 29(6):809-823. PubMed ID: 30924726
    [No Abstract]   [Full Text] [Related]  

  • 29. MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.
    Booher RN; Hatch H; Dolinski BM; Nguyen T; Harmonay L; Al-Assaad AS; Ayers M; Nebozhyn M; Loboda A; Hirsch HA; Zhang T; Shi B; Merkel CE; Angagaw MH; Wang Y; Long BJ; Lennon XQ; Miselis N; Pucci V; Monahan JW; Lee J; Kondic AG; Im EK; Mauro D; Blanchard R; Gilliland G; Fawell SE; Zawel L; Schuller AG; Strack P
    PLoS One; 2014; 9(10):e108371. PubMed ID: 25289887
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7.
    Hu S; Marineau JJ; Rajagopal N; Hamman KB; Choi YJ; Schmidt DR; Ke N; Johannessen L; Bradley MJ; Orlando DA; Alnemy SR; Ren Y; Ciblat S; Winter DK; Kabro A; Sprott KT; Hodgson JG; Fritz CC; Carulli JP; di Tomaso E; Olson ER
    Cancer Res; 2019 Jul; 79(13):3479-3491. PubMed ID: 31064851
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
    Kwiatkowski N; Zhang T; Rahl PB; Abraham BJ; Reddy J; Ficarro SB; Dastur A; Amzallag A; Ramaswamy S; Tesar B; Jenkins CE; Hannett NM; McMillin D; Sanda T; Sim T; Kim ND; Look T; Mitsiades CS; Weng AP; Brown JR; Benes CH; Marto JA; Young RA; Gray NS
    Nature; 2014 Jul; 511(7511):616-20. PubMed ID: 25043025
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Suppression of Angiogenesis by Targeting Cyclin-Dependent Kinase 7 in Human Umbilical Vein Endothelial Cells and Renal Cell Carcinoma: An In Vitro and In Vivo Study.
    Shi CS; Kuo KL; Chen MS; Chow PM; Liu SH; Chang YW; Lin WC; Liao SM; Hsu CH; Hsu FS; Chang HC; Huang KH
    Cells; 2019 Nov; 8(11):. PubMed ID: 31752390
    [TBL] [Abstract][Full Text] [Related]  

  • 33. THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing.
    Nilson KA; Guo J; Turek ME; Brogie JE; Delaney E; Luse DS; Price DH
    Mol Cell; 2015 Aug; 59(4):576-87. PubMed ID: 26257281
    [TBL] [Abstract][Full Text] [Related]  

  • 34. CDK7 is a reliable prognostic factor and novel therapeutic target in epithelial ovarian cancer.
    Kim J; Cho YJ; Ryu JY; Hwang I; Han HD; Ahn HJ; Kim WY; Cho H; Chung JY; Hewitt SM; Kim JH; Kim BG; Bae DS; Choi CH; Lee JW
    Gynecol Oncol; 2020 Jan; 156(1):211-221. PubMed ID: 31776040
    [TBL] [Abstract][Full Text] [Related]  

  • 35. High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma.
    Eliades P; Abraham BJ; Ji Z; Miller DM; Christensen CL; Kwiatkowski N; Kumar R; Njauw CN; Taylor M; Miao B; Zhang T; Wong KK; Gray NS; Young RA; Tsao H
    J Invest Dermatol; 2018 Jul; 138(7):1582-1590. PubMed ID: 29408204
    [TBL] [Abstract][Full Text] [Related]  

  • 36. A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax).
    Lam LT; Lu X; Zhang H; Lesniewski R; Rosenberg S; Semizarov D
    Mol Cancer Ther; 2010 Nov; 9(11):2943-50. PubMed ID: 20829195
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Bcl-x
    Hoffmeister-Wittmann P; Mock A; Nichetti F; Korell F; Heilig CE; Scherr AL; Günther M; Albrecht T; Kelmendi E; Xu K; Nader L; Kessler A; Schmitt N; Fritzsche S; Weiler S; Sobol B; Stenzinger A; Boeck S; Westphalen CB; Schulze-Osthoff K; Trojan J; Kindler T; Weichert W; Spiekermann K; Bitzer M; Folprecht G; Illert AL; Boerries M; Klauschen F; Ochsenreither S; Siveke J; Bauer S; Glimm H; Brors B; Hüllein J; Hübschmann D; Uhrig S; Horak P; Kreutzfeldt S; Banales JM; Springfeld C; Jäger D; Schirmacher P; Roessler S; Ormanns S; Goeppert B; Fröhling S; Köhler BC
    Liver Int; 2022 Dec; 42(12):2855-2870. PubMed ID: 35983950
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Antitumor effects of a covalent cyclin-dependent kinase 7 inhibitor in colorectal cancer.
    Wang J; Li Z; Mei H; Zhang D; Wu G; Zhang T; Lin Z
    Anticancer Drugs; 2019 Jun; 30(5):466-474. PubMed ID: 30694816
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Biological rational for sequential targeting of Bruton tyrosine kinase and Bcl-2 to overcome CD40-induced ABT-199 resistance in mantle cell lymphoma.
    Chiron D; Dousset C; Brosseau C; Touzeau C; Maïga S; Moreau P; Pellat-Deceunynck C; Le Gouill S; Amiot M
    Oncotarget; 2015 Apr; 6(11):8750-9. PubMed ID: 25797245
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL.
    Hari Y; Harashima N; Tajima Y; Harada M
    Oncotarget; 2015 Dec; 6(39):41902-15. PubMed ID: 26506422
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 15.