BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 31416831)

  • 1. The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates.
    Fernández-Justel D; Peláez R; Revuelta JL; Buey RM
    J Biol Chem; 2019 Oct; 294(40):14768-14775. PubMed ID: 31416831
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.
    Buey RM; Fernández-Justel D; Marcos-Alcalde Í; Winter G; Gómez-Puertas P; de Pereda JM; Luis Revuelta J
    Sci Rep; 2017 Jun; 7(1):2648. PubMed ID: 28572600
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase.
    Fernández-Justel D; Marcos-Alcalde Í; Abascal F; Vidaña N; Gómez-Puertas P; Jiménez A; Revuelta JL; Buey RM
    Protein Sci; 2022 May; 31(5):e4314. PubMed ID: 35481629
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases.
    Buey RM; Ledesma-Amaro R; Velázquez-Campoy A; Balsera M; Chagoyen M; de Pereda JM; Revuelta JL
    Nat Commun; 2015 Nov; 6():8923. PubMed ID: 26558346
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity.
    Fernández-Justel D; Núñez R; Martín-Benito J; Jimeno D; González-López A; Soriano EM; Revuelta JL; Buey RM
    J Mol Biol; 2019 Mar; 431(5):956-969. PubMed ID: 30664871
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
    Makowska-Grzyska M; Kim Y; Maltseva N; Osipiuk J; Gu M; Zhang M; Mandapati K; Gollapalli DR; Gorla SK; Hedstrom L; Joachimiak A
    J Biol Chem; 2015 Feb; 290(9):5893-911. PubMed ID: 25572472
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.
    Labesse G; Alexandre T; Gelin M; Haouz A; Munier-Lehmann H
    Acta Crystallogr D Biol Crystallogr; 2015 Sep; 71(Pt 9):1890-9. PubMed ID: 26327379
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases.
    Buey RM; Fernández-Justel D; Jiménez A; Revuelta JL
    Protein Sci; 2022 Sep; 31(9):e4399. PubMed ID: 36040265
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MgATP regulates allostery and fiber formation in IMPDHs.
    Labesse G; Alexandre T; Vaupré L; Salard-Arnaud I; Him JL; Raynal B; Bron P; Munier-Lehmann H
    Structure; 2013 Jun; 21(6):975-85. PubMed ID: 23643948
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Increased riboflavin production by manipulation of inosine 5'-monophosphate dehydrogenase in Ashbya gossypii.
    Buey RM; Ledesma-Amaro R; Balsera M; de Pereda JM; Revuelta JL
    Appl Microbiol Biotechnol; 2015 Nov; 99(22):9577-89. PubMed ID: 26150243
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
    Gedeon A; Ayoub N; Brûlé S; Raynal B; Karimova G; Gelin M; Mechaly A; Haouz A; Labesse G; Munier-Lehmann H
    Protein Sci; 2023 Aug; 32(8):e4703. PubMed ID: 37338125
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis.
    Gan L; Petsko GA; Hedstrom L
    Biochemistry; 2002 Nov; 41(44):13309-17. PubMed ID: 12403633
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.
    McMillan FM; Cahoon M; White A; Hedstrom L; Petsko GA; Ringe D
    Biochemistry; 2000 Apr; 39(15):4533-42. PubMed ID: 10758003
    [TBL] [Abstract][Full Text] [Related]  

  • 14. First-in-class allosteric inhibitors of bacterial IMPDHs.
    Alexandre T; Lupan A; Helynck O; Vichier-Guerre S; Dugué L; Gelin M; Haouz A; Labesse G; Munier-Lehmann H
    Eur J Med Chem; 2019 Apr; 167():124-132. PubMed ID: 30769241
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A regulatory role of the Bateman domain of IMP dehydrogenase in adenylate nucleotide biosynthesis.
    Pimkin M; Pimkina J; Markham GD
    J Biol Chem; 2009 Mar; 284(12):7960-9. PubMed ID: 19153081
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms.
    Thomas EC; Gunter JH; Webster JA; Schieber NL; Oorschot V; Parton RG; Whitehead JP
    PLoS One; 2012; 7(12):e51096. PubMed ID: 23236438
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase.
    Zhang R; Evans G; Rotella FJ; Westbrook EM; Beno D; Huberman E; Joachimiak A; Collart FR
    Biochemistry; 1999 Apr; 38(15):4691-700. PubMed ID: 10200156
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The roles of conserved carboxylate residues in IMP dehydrogenase and identification of a transition state analog.
    Kerr KM; Hedstrom L
    Biochemistry; 1997 Oct; 36(43):13365-73. PubMed ID: 9341229
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
    Sintchak MD; Fleming MA; Futer O; Raybuck SA; Chambers SP; Caron PR; Murcko MA; Wilson KP
    Cell; 1996 Jun; 85(6):921-30. PubMed ID: 8681386
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism.
    Prosise GL; Luecke H
    J Mol Biol; 2003 Feb; 326(2):517-27. PubMed ID: 12559919
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.