BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

598 related articles for article (PubMed ID: 31447348)

  • 41. New Targeted Agents in Gynecologic Cancers: Synthetic Lethality, Homologous Recombination Deficiency, and PARP Inhibitors.
    Liu FW; Tewari KS
    Curr Treat Options Oncol; 2016 Mar; 17(3):12. PubMed ID: 26931795
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.
    Wiltshire TD; Lovejoy CA; Wang T; Xia F; O'Connor MJ; Cortez D
    J Biol Chem; 2010 May; 285(19):14565-71. PubMed ID: 20233726
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Transcription-replication conflicts underlie sensitivity to PARP inhibitors.
    Petropoulos M; Karamichali A; Rossetti GG; Freudenmann A; Iacovino LG; Dionellis VS; Sotiriou SK; Halazonetis TD
    Nature; 2024 Apr; 628(8007):433-441. PubMed ID: 38509368
    [TBL] [Abstract][Full Text] [Related]  

  • 44. The effect of the triazene compound CT913 on ovarian cancer cells in vitro and its synergistic interaction with the PARP-inhibitor olaparib.
    Wichmann C; Klotz DM; Zeiler HJ; Hilger RA; Grützmann K; Krüger A; Aust D; Wimberger P; Kuhlmann JD
    Gynecol Oncol; 2020 Dec; 159(3):850-859. PubMed ID: 32980128
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent.
    Sizemore ST; Mohammad R; Sizemore GM; Nowsheen S; Yu H; Ostrowski MC; Chakravarti A; Xia F
    Mol Cancer Res; 2018 Jul; 16(7):1092-1102. PubMed ID: 29592899
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Kub5-Hera
    Motea EA; Fattah FJ; Xiao L; Girard L; Rommel A; Morales JC; Patidar P; Zhou Y; Porter A; Xie Y; Minna JD; Boothman DA
    Clin Cancer Res; 2018 Dec; 24(24):6459-6470. PubMed ID: 30108102
    [TBL] [Abstract][Full Text] [Related]  

  • 47. TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks.
    Ma J; Zhou Y; Pan P; Yu H; Wang Z; Li LL; Wang B; Yan Y; Pan Y; Ye Q; Liu T; Feng X; Xu S; Wang K; Wang X; Jian Y; Ma B; Fan Y; Gao Y; Huang H; Li L
    Nat Commun; 2023 Mar; 14(1):1810. PubMed ID: 37002234
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.
    Caron MC; Sharma AK; O'Sullivan J; Myler LR; Ferreira MT; Rodrigue A; Coulombe Y; Ethier C; Gagné JP; Langelier MF; Pascal JM; Finkelstein IJ; Hendzel MJ; Poirier GG; Masson JY
    Nat Commun; 2019 Jul; 10(1):2954. PubMed ID: 31273204
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage.
    Giovannini S; Weller MC; Repmann S; Moch H; Jiricny J
    Nucleic Acids Res; 2019 Sep; 47(17):9132-9143. PubMed ID: 31329989
    [TBL] [Abstract][Full Text] [Related]  

  • 50. PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1.
    Lodovichi S; Quadri R; Sertic S; Pellicioli A
    Cell Rep; 2023 Feb; 42(2):112060. PubMed ID: 36735534
    [TBL] [Abstract][Full Text] [Related]  

  • 51. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors.
    Peng Y; Liao Q; Tan W; Peng C; Hu Z; Chen Y; Li Z; Li J; Zhen B; Zhu W; Li X; Yao Y; Song Q; Liu C; Qi X; He F; Pei H
    Nat Commun; 2019 Mar; 10(1):1224. PubMed ID: 30874560
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.
    Min A; Im SA; Kim DK; Song SH; Kim HJ; Lee KH; Kim TY; Han SW; Oh DY; Kim TY; O'Connor MJ; Bang YJ
    Breast Cancer Res; 2015 Mar; 17():33. PubMed ID: 25888415
    [TBL] [Abstract][Full Text] [Related]  

  • 53. 53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.
    Hurley RM; Wahner Hendrickson AE; Visscher DW; Ansell P; Harrell MI; Wagner JM; Negron V; Goergen KM; Maurer MJ; Oberg AL; Meng XW; Flatten KS; De Jonge MJA; Van Herpen CD; Gietema JA; Koornstra RHT; Jager A; den Hollander MW; Dudley M; Shepherd SP; Swisher EM; Kaufmann SH
    Gynecol Oncol; 2019 Apr; 153(1):127-134. PubMed ID: 30686551
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.
    Ireno IC; Wiehe RS; Stahl AI; Hampp S; Aydin S; Troester MA; Selivanova G; Wiesmüller L
    Carcinogenesis; 2014 Oct; 35(10):2273-82. PubMed ID: 25085902
    [TBL] [Abstract][Full Text] [Related]  

  • 55. PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas.
    Czyż M; Toma M; Gajos-Michniewicz A; Majchrzak K; Hoser G; Szemraj J; Nieborowska-Skorska M; Cheng P; Gritsyuk D; Levesque M; Dummer R; Sliwinski T; Skorski T
    Oncotarget; 2016 Nov; 7(46):75551-75560. PubMed ID: 27705909
    [TBL] [Abstract][Full Text] [Related]  

  • 56. LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.
    Chen L; Hou J; Zeng X; Guo Q; Deng M; Kloeber JA; Tu X; Zhao F; Wu Z; Huang J; Luo K; Kim W; Lou Z
    Clin Transl Med; 2021 Mar; 11(3):e341. PubMed ID: 33784003
    [TBL] [Abstract][Full Text] [Related]  

  • 57. NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition.
    Bishara LA; Machour FE; Awwad SW; Ayoub N
    DNA Repair (Amst); 2021 Jan; 97():103025. PubMed ID: 33248388
    [TBL] [Abstract][Full Text] [Related]  

  • 58. BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.
    Aly A; Ganesan S
    J Mol Cell Biol; 2011 Feb; 3(1):66-74. PubMed ID: 21278454
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Drug-Driven Synthetic Lethality: Bypassing Tumor Cell Genetics with a Combination of AsiDNA and PARP Inhibitors.
    Jdey W; Thierry S; Russo C; Devun F; Al Abo M; Noguiez-Hellin P; Sun JS; Barillot E; Zinovyev A; Kuperstein I; Pommier Y; Dutreix M
    Clin Cancer Res; 2017 Feb; 23(4):1001-1011. PubMed ID: 27559053
    [No Abstract]   [Full Text] [Related]  

  • 60. Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer.
    Carey JPW; Karakas C; Bui T; Chen X; Vijayaraghavan S; Zhao Y; Wang J; Mikule K; Litton JK; Hunt KK; Keyomarsi K
    Cancer Res; 2018 Feb; 78(3):742-757. PubMed ID: 29180466
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 30.