These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

203 related articles for article (PubMed ID: 31451509)

  • 1. Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function.
    Kattan WE; Chen W; Ma X; Lan TH; van der Hoeven D; van der Hoeven R; Hancock JF
    Life Sci Alliance; 2019 Oct; 2(5):. PubMed ID: 31451509
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer.
    Kattan WE; Liu J; Montufar-Solis D; Liang H; Brahmendra Barathi B; van der Hoeven R; Zhou Y; Hancock JF
    Proc Natl Acad Sci U S A; 2021 Dec; 118(51):. PubMed ID: 34903667
    [TBL] [Abstract][Full Text] [Related]  

  • 3. ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P
    Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H
    Nat Commun; 2017 Oct; 8(1):757. PubMed ID: 28970484
    [TBL] [Abstract][Full Text] [Related]  

  • 4. INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts.
    Chung J; Torta F; Masai K; Lucast L; Czapla H; Tanner LB; Narayanaswamy P; Wenk MR; Nakatsu F; De Camilli P
    Science; 2015 Jul; 349(6246):428-32. PubMed ID: 26206935
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PtdSer as a signaling lipid determined by privileged localization of ORP5 and ORP8 at ER/PM junctional foci to determine PM and ER PtdSer/PI(4)P ratio and cell function.
    Chung WY; Ahuja M; McNally BA; Leibow SR; Ohman HKE; Movahed Abtahi A; Muallem S
    Proc Natl Acad Sci U S A; 2023 Aug; 120(35):e2301410120. PubMed ID: 37607230
    [TBL] [Abstract][Full Text] [Related]  

  • 6. PI(4,5)P
    Sohn M; Korzeniowski M; Zewe JP; Wills RC; Hammond GRV; Humpolickova J; Vrzal L; Chalupska D; Veverka V; Fairn GD; Boura E; Balla T
    J Cell Biol; 2018 May; 217(5):1797-1813. PubMed ID: 29472386
    [TBL] [Abstract][Full Text] [Related]  

  • 7. ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.
    Galmes R; Houcine A; van Vliet AR; Agostinis P; Jackson CL; Giordano F
    EMBO Rep; 2016 Jun; 17(6):800-10. PubMed ID: 27113756
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Myotubularin-related proteins regulate KRAS function by controlling plasma membrane levels of polyphosphoinositides and phosphatidylserine.
    Henkels KM; Miller TE; Naji A; van der Hoeven R; Liang H; Zhou Y; Hammond GRV; Hancock JF; Cho KJ
    bioRxiv; 2024 Jan; ():. PubMed ID: 38328115
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
    Adhikari H; Kattan WE; Kumar S; Zhou P; Hancock JF; Counter CM
    Nat Commun; 2021 Sep; 12(1):5248. PubMed ID: 34504076
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Acylpeptide hydrolase is a novel regulator of KRAS plasma membrane localization and function.
    Tan L; Cho KJ; Kattan WE; Garrido CM; Zhou Y; Neupane P; Capon RJ; Hancock JF
    J Cell Sci; 2019 Jul; 132(15):. PubMed ID: 31266814
    [TBL] [Abstract][Full Text] [Related]  

  • 11. An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth.
    Tan L; Cho KJ; Neupane P; Capon RJ; Hancock JF
    J Biol Chem; 2018 Aug; 293(35):13696-13706. PubMed ID: 29970615
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria.
    Miller TE; Henkels KM; Huddleston M; Salisbury R; Hussain SM; Sasaki AT; Cho KJ
    J Cell Sci; 2019 Aug; 132(16):. PubMed ID: 31331963
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling.
    Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H
    J Biol Chem; 2018 Mar; 293(10):3806-3818. PubMed ID: 29358326
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites?
    Santos NC; Girik V; Nunes-Hasler P
    Biomolecules; 2020 Jun; 10(6):. PubMed ID: 32570981
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure.
    Zhou Y; Prakash PS; Liang H; Gorfe AA; Hancock JF
    Proc Natl Acad Sci U S A; 2021 Feb; 118(6):. PubMed ID: 33526670
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.
    Lakshman B; Messing S; Schmid EM; Clogston JD; Gillette WK; Esposito D; Kessing B; Fletcher DA; Nissley DV; McCormick F; Stephen AG; Jean-Francois FL
    J Biol Chem; 2019 Feb; 294(6):2193-2207. PubMed ID: 30559287
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair.
    Yang L; Shen C; Estrada-Bernal A; Robb R; Chatterjee M; Sebastian N; Webb A; Mo X; Chen W; Krishnan S; Williams TM
    Nucleic Acids Res; 2021 Nov; 49(19):11067-11082. PubMed ID: 34606602
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments.
    Pulli I; Lassila T; Pan G; Yan D; Olkkonen VM; Törnquist K
    Cell Calcium; 2018 Jun; 72():62-69. PubMed ID: 29748134
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The G protein-coupled receptor GPR31 promotes membrane association of KRAS.
    Fehrenbacher N; Tojal da Silva I; Ramirez C; Zhou Y; Cho KJ; Kuchay S; Shi J; Thomas S; Pagano M; Hancock JF; Bar-Sagi D; Philips MR
    J Cell Biol; 2017 Aug; 216(8):2329-2338. PubMed ID: 28619714
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A novel prenyl-polybasic domain code determines lipid-binding specificity of the K-Ras membrane anchor.
    Zhou Y; Hancock JF
    Small GTPases; 2020 May; 11(3):220-224. PubMed ID: 29239694
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.