335 related articles for article (PubMed ID: 31455613)
1. Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing.
Chen L; Ma MY; Sun M; Jiang LY; Zhao XT; Fang XX; Man Lam S; Shui GH; Luo J; Shi XJ; Song BL
J Lipid Res; 2019 Oct; 60(10):1765-1775. PubMed ID: 31455613
[TBL] [Abstract][Full Text] [Related]
2. Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.
Sagimori I; Yoshioka H; Hashimoto Y; Ohgane K
Bioorg Med Chem; 2020 Feb; 28(3):115298. PubMed ID: 31902650
[TBL] [Abstract][Full Text] [Related]
3. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Loregger A; Raaben M; Tan J; Scheij S; Moeton M; van den Berg M; Gelberg-Etel H; Stickel E; Roitelman J; Brummelkamp T; Zelcer N
Arterioscler Thromb Vasc Biol; 2017 Nov; 37(11):2064-2074. PubMed ID: 28882874
[TBL] [Abstract][Full Text] [Related]
4. Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis.
Lu H; Talbot S; Robertson KA; Watterson S; Forster T; Roy D; Ghazal P
Steroids; 2015 Jul; 99(Pt B):219-29. PubMed ID: 25759117
[TBL] [Abstract][Full Text] [Related]
5. An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer.
Longo J; Mullen PJ; Yu R; van Leeuwen JE; Masoomian M; Woon DTS; Wang Y; Chen EX; Hamilton RJ; Sweet JM; van der Kwast TH; Fleshner NE; Penn LZ
Mol Metab; 2019 Jul; 25():119-130. PubMed ID: 31023626
[TBL] [Abstract][Full Text] [Related]
6. Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevalonate.
Straka MS; Panini SR
Arch Biochem Biophys; 1995 Feb; 317(1):235-43. PubMed ID: 7872789
[TBL] [Abstract][Full Text] [Related]
7. Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase.
Faulkner RA; Yang Y; Tsien J; Qin T; DeBose-Boyd RA
Proc Natl Acad Sci U S A; 2024 Feb; 121(7):e2318822121. PubMed ID: 38319967
[TBL] [Abstract][Full Text] [Related]
8. Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity.
Panini SR; Schnitzer-Polokoff R; Spencer TA; Sinensky M
J Biol Chem; 1989 Jul; 264(19):11044-52. PubMed ID: 2567731
[TBL] [Abstract][Full Text] [Related]
9. Bisphenol A induces cholesterol biosynthesis in HepG2 cells via SREBP-2/HMGCR signaling pathway.
Li Q; Zhang H; Zou J; Feng X; Feng D
J Toxicol Sci; 2019; 44(7):481-491. PubMed ID: 31270304
[TBL] [Abstract][Full Text] [Related]
10. Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity.
Wall CTJ; Lefebvre G; Metairon S; Descombes P; Wiederkehr A; Santo-Domingo J
J Biol Chem; 2022 Mar; 298(3):101652. PubMed ID: 35101444
[TBL] [Abstract][Full Text] [Related]
11. New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis.
Howe V; Sharpe LJ; Prabhu AV; Brown AJ
Biochim Biophys Acta Mol Cell Biol Lipids; 2017 Jul; 1862(7):647-657. PubMed ID: 28342963
[TBL] [Abstract][Full Text] [Related]
12. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.
Theesfeld CL; Hampton RY
J Biol Chem; 2013 Mar; 288(12):8519-8530. PubMed ID: 23306196
[TBL] [Abstract][Full Text] [Related]
13. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.
Sever N; Yang T; Brown MS; Goldstein JL; DeBose-Boyd RA
Mol Cell; 2003 Jan; 11(1):25-33. PubMed ID: 12535518
[TBL] [Abstract][Full Text] [Related]
14. Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver.
Hwang S; Hartman IZ; Calhoun LN; Garland K; Young GA; Mitsche MA; McDonald J; Xu F; Engelking L; DeBose-Boyd RA
J Biol Chem; 2016 Jun; 291(26):13479-94. PubMed ID: 27129778
[TBL] [Abstract][Full Text] [Related]
15. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol.
Song BL; Javitt NB; DeBose-Boyd RA
Cell Metab; 2005 Mar; 1(3):179-89. PubMed ID: 16054061
[TBL] [Abstract][Full Text] [Related]
16. Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis.
Trzaskos JM; Magolda RL; Favata MF; Fischer RT; Johnson PR; Chen HW; Ko SS; Leonard DA; Gaylor JL
J Biol Chem; 1993 Oct; 268(30):22591-9. PubMed ID: 7693673
[TBL] [Abstract][Full Text] [Related]
17. Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol.
Iglesias J; Gibbons GF
Biochem J; 1989 Dec; 264(2):495-502. PubMed ID: 2604729
[TBL] [Abstract][Full Text] [Related]
18. Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.
Jiang LY; Jiang W; Tian N; Xiong YN; Liu J; Wei J; Wu KY; Luo J; Shi XJ; Song BL
J Biol Chem; 2018 Mar; 293(11):4047-4055. PubMed ID: 29374057
[TBL] [Abstract][Full Text] [Related]
19. Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase.
Göbel A; Pählig S; Motz A; Breining D; Traikov S; Hofbauer LC; Rachner TD
Biochem Biophys Res Commun; 2024 May; 710():149841. PubMed ID: 38588613
[TBL] [Abstract][Full Text] [Related]
20. The mevalonate pathway during acute tubular injury: selected determinants and consequences.
Zager RA; Shah VO; Shah HV; Zager PG; Johnson AC; Hanson S
Am J Pathol; 2002 Aug; 161(2):681-92. PubMed ID: 12163393
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
