315 related articles for article (PubMed ID: 31469332)
1. Benzimidazole inhibitors of the major cysteine protease of
Pereira GA; Santos LH; Wang SC; Martins LC; Villela FS; Liao W; Dessoy MA; Dias LC; Andricopulo AD; Costa MA; Nagem RA; Caffrey CR; Liedl KR; Caffarena ER; Ferreira RS
Future Med Chem; 2019 Jul; 11(13):1537-1551. PubMed ID: 31469332
[No Abstract] [Full Text] [Related]
2. Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.
Pereira GAN; da Silva EB; Braga SFP; Leite PG; Martins LC; Vieira RP; Soh WT; Villela FS; Costa FMR; Ray D; de Andrade SF; Brandstetter H; Oliveira RB; Caffrey CR; Machado FS; Ferreira RS
Eur J Med Chem; 2019 Oct; 179():765-778. PubMed ID: 31284086
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.
Yang PY; Wang M; Li L; Wu H; He CY; Yao SQ
Chemistry; 2012 May; 18(21):6528-41. PubMed ID: 22488888
[TBL] [Abstract][Full Text] [Related]
4. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain.
McShan D; Kathman S; Lowe B; Xu Z; Zhan J; Statsyuk A; Ogungbe IV
Bioorg Med Chem Lett; 2015 Oct; 25(20):4509-12. PubMed ID: 26342866
[TBL] [Abstract][Full Text] [Related]
5. Understanding Structure-Activity Relationships for Trypanosomal Cysteine Protease Inhibitors by Simulations and Free Energy Calculations.
Santos LH; Waldner BJ; Fuchs JE; Pereira GAN; Liedl KR; Caffarena ER; Ferreira RS
J Chem Inf Model; 2019 Jan; 59(1):137-148. PubMed ID: 30532974
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.
Fonseca NC; da Cruz LF; da Silva Villela F; do Nascimento Pereira GA; de Siqueira-Neto JL; Kellar D; Suzuki BM; Ray D; de Souza TB; Alves RJ; Sales Júnior PA; Romanha AJ; Murta SM; McKerrow JH; Caffrey CR; de Oliveira RB; Ferreira RS
Antimicrob Agents Chemother; 2015 May; 59(5):2666-77. PubMed ID: 25712353
[TBL] [Abstract][Full Text] [Related]
7. Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment.
Maiorana S; Ettari R; Previti S; Amendola G; Wagner A; Cosconati S; Hellmich UA; Schirmeister T; Zappalà M
ChemMedChem; 2020 Aug; 15(16):1552-1561. PubMed ID: 32567172
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
Greenbaum DC; Mackey Z; Hansell E; Doyle P; Gut J; Caffrey CR; Lehrman J; Rosenthal PJ; McKerrow JH; Chibale K
J Med Chem; 2004 Jun; 47(12):3212-9. PubMed ID: 15163200
[TBL] [Abstract][Full Text] [Related]
9. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
Mott BT; Ferreira RS; Simeonov A; Jadhav A; Ang KK; Leister W; Shen M; Silveira JT; Doyle PS; Arkin MR; McKerrow JH; Inglese J; Austin CP; Thomas CJ; Shoichet BK; Maloney DJ
J Med Chem; 2010 Jan; 53(1):52-60. PubMed ID: 19908842
[TBL] [Abstract][Full Text] [Related]
10. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Mallari JP; Shelat A; Kosinski A; Caffrey CR; Connelly M; Zhu F; McKerrow JH; Guy RK
Bioorg Med Chem Lett; 2008 May; 18(9):2883-5. PubMed ID: 18420405
[TBL] [Abstract][Full Text] [Related]
11. The Inhibition of Cysteine Proteases Rhodesain and TbCatB: A Valuable Approach to Treat Human African Trypanosomiasis.
Ettari R; Previti S; Tamborini L; Cullia G; Grasso S; Zappalà M
Mini Rev Med Chem; 2016; 16(17):1374-1391. PubMed ID: 27156518
[TBL] [Abstract][Full Text] [Related]
12. Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors.
Pauli I; Ferreira LG; de Souza ML; Oliva G; Ferreira RS; Dessoy MA; Slafer BW; Dias LC; Andricopulo AD
Future Med Chem; 2017 May; 9(7):641-657. PubMed ID: 28509592
[TBL] [Abstract][Full Text] [Related]
13. Aryl ureas represent a new class of anti-trypanosomal agents.
Du X; Hansell E; Engel JC; Caffrey CR; Cohen FE; McKerrow JH
Chem Biol; 2000 Sep; 7(9):733-42. PubMed ID: 10980453
[TBL] [Abstract][Full Text] [Related]
14. Vinyl sulfone-based inhibitors of trypanosomal cysteine protease rhodesain with improved antitrypanosomal activities.
Zhang H; Collins J; Nyamwihura R; Crown O; Ajayi O; Ogungbe IV
Bioorg Med Chem Lett; 2020 Jul; 30(14):127217. PubMed ID: 32527539
[TBL] [Abstract][Full Text] [Related]
15. Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
Previti S; Ettari R; Cosconati S; Amendola G; Chouchene K; Wagner A; Hellmich UA; Ulrich K; Krauth-Siegel RL; Wich PR; Schmid I; Schirmeister T; Gut J; Rosenthal PJ; Grasso S; Zappalà M
J Med Chem; 2017 Aug; 60(16):6911-6923. PubMed ID: 28763614
[TBL] [Abstract][Full Text] [Related]
16. Structure-Based Optimization of Quinazolines as Cruzain and
Barbosa da Silva E; Rocha DA; Fortes IS; Yang W; Monti L; Siqueira-Neto JL; Caffrey CR; McKerrow J; Andrade SF; Ferreira RS
J Med Chem; 2021 Sep; 64(17):13054-13071. PubMed ID: 34461718
[TBL] [Abstract][Full Text] [Related]
17. Targeting Cysteine Proteases and their Inhibitors to Combat Trypanosomiasis.
Saha A; Pushpa ; Moitra S; Basak D; Brahma S; Mondal D; Molla SH; Samadder A; Nandi S
Curr Med Chem; 2024; 31(16):2135-2169. PubMed ID: 37340748
[TBL] [Abstract][Full Text] [Related]
18. Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives.
Lavrado J; Mackey Z; Hansell E; McKerrow JH; Paulo A; Moreira R
Bioorg Med Chem Lett; 2012 Oct; 22(19):6256-60. PubMed ID: 22926067
[TBL] [Abstract][Full Text] [Related]
19. Targeting cysteine proteases in trypanosomatid disease drug discovery.
Ferreira LG; Andricopulo AD
Pharmacol Ther; 2017 Dec; 180():49-61. PubMed ID: 28579388
[TBL] [Abstract][Full Text] [Related]
20. Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei.
Schirmeister T; Schmitz J; Jung S; Schmenger T; Krauth-Siegel RL; Gütschow M
Bioorg Med Chem Lett; 2017 Jan; 27(1):45-50. PubMed ID: 27890381
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]