BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 31471167)

  • 1. Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
    Large JM; Birchall K; Bouloc NS; Merritt AT; Smiljanic-Hurley E; Tsagris DJ; Wheldon MC; Ansell KH; Coombs PJ; Kettleborough CA; Whalley D; Stewart LB; Bowyer PW; Baker DA; Osborne SA
    Bioorg Med Chem Lett; 2019 Oct; 29(19):126610. PubMed ID: 31471167
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
    Large JM; Birchall K; Bouloc NS; Merritt AT; Smiljanic-Hurley E; Tsagris DJ; Wheldon MC; Ansell KH; Coombs PJ; Kettleborough CA; Whalley D; Stewart LB; Bowyer PW; Baker DA; Osborne SA
    Bioorg Med Chem Lett; 2019 Feb; 29(3):509-514. PubMed ID: 30553738
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
    Baker DA; Stewart LB; Large JM; Bowyer PW; Ansell KH; Jiménez-Díaz MB; El Bakkouri M; Birchall K; Dechering KJ; Bouloc NS; Coombs PJ; Whalley D; Harding DJ; Smiljanic-Hurley E; Wheldon MC; Walker EM; Dessens JT; Lafuente MJ; Sanz LM; Gamo FJ; Ferrer SB; Hui R; Bousema T; Angulo-Barturén I; Merritt AT; Croft SL; Gutteridge WE; Kettleborough CA; Osborne SA
    Nat Commun; 2017 Sep; 8(1):430. PubMed ID: 28874661
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
    Tsagris DJ; Birchall K; Bouloc N; Large JM; Merritt A; Smiljanic-Hurley E; Wheldon M; Ansell KH; Kettleborough C; Whalley D; Stewart LB; Bowyer PW; Baker DA; Osborne SA
    Bioorg Med Chem Lett; 2018 Oct; 28(19):3168-3173. PubMed ID: 30174152
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.
    Green JL; Moon RW; Whalley D; Bowyer PW; Wallace C; Rochani A; Nageshan RK; Howell SA; Grainger M; Jones HM; Ansell KH; Chapman TM; Taylor DL; Osborne SA; Baker DA; Tatu U; Holder AA
    Antimicrob Agents Chemother; 2015 Dec; 60(3):1464-75. PubMed ID: 26711771
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor.
    Diaz CA; Allocco J; Powles MA; Yeung L; Donald RG; Anderson JW; Liberator PA
    Mol Biochem Parasitol; 2006 Mar; 146(1):78-88. PubMed ID: 16325279
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanism of allosteric inhibition in the
    Byun JA; Van K; Huang J; Henning P; Franz E; Akimoto M; Herberg FW; Kim C; Melacini G
    J Biol Chem; 2020 Jun; 295(25):8480-8491. PubMed ID: 32317283
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.
    Eck T; Laureano de Souza M; Delvillar M; Ashraf K; Yadav Bheemanaboina RR; Chakrasali R; Kreiss T; Siekierka JJ; Rotella DP; Bhanot P; Goodey NM
    Chembiochem; 2022 Apr; 23(7):e202100704. PubMed ID: 35044710
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting Plasmodium falciparum protein kinases with adenosine analogue-oligoarginine conjugates.
    Lavogina D; Budu A; Enkvist E; Hopp CS; Baker DA; Langsley G; Garcia CR; Uri A
    Exp Parasitol; 2014 Mar; 138():55-62. PubMed ID: 24534615
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase.
    Hopp CS; Flueck C; Solyakov L; Tobin A; Baker DA
    PLoS One; 2012; 7(11):e48206. PubMed ID: 23139764
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
    Chapman TM; Osborne SA; Bouloc N; Large JM; Wallace C; Birchall K; Ansell KH; Jones HM; Taylor D; Clough B; Green JL; Holder AA
    Bioorg Med Chem Lett; 2013 May; 23(10):3064-9. PubMed ID: 23570789
    [TBL] [Abstract][Full Text] [Related]  

  • 12. High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites.
    Penzo M; de Las Heras-Dueña L; Mata-Cantero L; Diaz-Hernandez B; Vazquez-Muñiz MJ; Ghidelli-Disse S; Drewes G; Fernandez-Alvaro E; Baker DA
    Sci Rep; 2019 May; 9(1):7005. PubMed ID: 31065005
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.
    Liang GB; Qian X; Feng D; Fisher M; Brown CM; Gurnett A; Leavitt PS; Liberator PA; Misura AS; Tamas T; Schmatz DM; Wyvratt M; Biftu T
    Bioorg Med Chem Lett; 2007 Jul; 17(13):3558-61. PubMed ID: 17475489
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity.
    Varghese S; Rahmani R; Drew DR; Beeson JG; Baum J; Smith BJ; Baell JB
    ChemMedChem; 2021 Feb; 16(4):679-693. PubMed ID: 32929894
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A novel cyclic GMP-dependent protein kinase is expressed in the ring stage of the Plasmodium falciparum life cycle.
    Deng W; Baker DA
    Mol Microbiol; 2002 Jun; 44(5):1141-51. PubMed ID: 12068803
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites.
    Chouteau F; Ramanitrahasimbola D; Rasoanaivo P; Chibale K
    Bioorg Med Chem Lett; 2005 Jun; 15(12):3024-8. PubMed ID: 15908208
    [TBL] [Abstract][Full Text] [Related]  

  • 17. cGMP Binding Domain D Mediates a Unique Activation Mechanism in Plasmodium falciparum PKG.
    Franz E; Knape MJ; Herberg FW
    ACS Infect Dis; 2018 Mar; 4(3):415-423. PubMed ID: 29251493
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum.
    Deng W; Parbhu-Patel A; Meyer DJ; Baker DA
    Biochem J; 2003 Sep; 374(Pt 2):559-65. PubMed ID: 12817987
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony.
    Taylor HM; McRobert L; Grainger M; Sicard A; Dluzewski AR; Hopp CS; Holder AA; Baker DA
    Eukaryot Cell; 2010 Jan; 9(1):37-45. PubMed ID: 19915077
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target.
    Tewari R; Patzewitz EM; Poulin B; Stewart L; Baker DA
    PLoS One; 2014; 9(5):e96923. PubMed ID: 24805991
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.