110 related articles for article (PubMed ID: 31472121)
1. CYP1A2 Downregulation by Obeticholic Acid: Usefulness as a Positive Control for the In Vitro Evaluation of Drug-Drug Interactions.
Ishida C; Sanoh S; Kotake Y
J Pharm Sci; 2019 Dec; 108(12):3903-3910. PubMed ID: 31472121
[TBL] [Abstract][Full Text] [Related]
2. Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.
Vrzal R; Daujat-Chavanieu M; Pascussi JM; Ulrichova J; Maurel P; Dvorak Z
Eur J Pharmacol; 2008 Mar; 581(3):244-54. PubMed ID: 18177856
[TBL] [Abstract][Full Text] [Related]
3. Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects.
Edwards JE; Eliot L; Parkinson A; Karan S; MacConell L
Adv Ther; 2017 Sep; 34(9):2120-2138. PubMed ID: 28808886
[TBL] [Abstract][Full Text] [Related]
4. Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells.
Ogasawara A; Kato N; Torimoto N; Aohara F; Ohashi R; Yamada Y; Taniguchi H
Drug Metab Lett; 2018; 12(1):14-23. PubMed ID: 29357810
[TBL] [Abstract][Full Text] [Related]
5. Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.
Rhodes SP; Otten JN; Hingorani GP; Hartley DP; Franklin RB
J Pharmacol Toxicol Methods; 2011; 63(3):223-6. PubMed ID: 21111054
[TBL] [Abstract][Full Text] [Related]
6. TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes.
Matsuoka-Kawano K; Yoshinari K; Nagayama S; Yamazoe Y
Chem Biol Interact; 2010 Apr; 185(1):33-41. PubMed ID: 20171196
[TBL] [Abstract][Full Text] [Related]
7. An 'all-inclusive' 96-well cytochrome P450 induction method: measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes.
Halladay JS; Wong S; Khojasteh SC; Grepper S
J Pharmacol Toxicol Methods; 2012; 66(3):270-5. PubMed ID: 22809809
[TBL] [Abstract][Full Text] [Related]
8. Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice.
Singh AB; Dong B; Kraemer FB; Xu Y; Zhang Y; Liu J
Arterioscler Thromb Vasc Biol; 2018 Oct; 38(10):2448-2459. PubMed ID: 30354208
[TBL] [Abstract][Full Text] [Related]
9. Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes.
Vrzal R; Stejskalova L; Monostory K; Maurel P; Bachleda P; Pavek P; Dvorak Z
Chem Biol Interact; 2009 May; 179(2-3):288-96. PubMed ID: 19022236
[TBL] [Abstract][Full Text] [Related]
10. Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines.
Wu R; Cui X; Dong W; Zhou M; Simms HH; Wang P
Int J Mol Med; 2006 Aug; 18(2):339-46. PubMed ID: 16820944
[TBL] [Abstract][Full Text] [Related]
11. Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes.
Dvorák Z; Vrzal R; Starha P; Klanicová A; Trávnícek Z
Toxicol In Vitro; 2010 Mar; 24(2):425-9. PubMed ID: 19854261
[TBL] [Abstract][Full Text] [Related]
12. Cryopreserved human hepatocytes as alternative in vitro model for cytochrome p450 induction studies.
Garcia M; Rager J; Wang Q; Strab R; Hidalgo IJ; Owen A; Li J
In Vitro Cell Dev Biol Anim; 2003; 39(7):283-7. PubMed ID: 14599235
[TBL] [Abstract][Full Text] [Related]
13. New Screening Criteria Setting on Evaluation of Cytochrome P450 Induction Using HepaRG Cells with Multiplex Branched DNA Technologies in Early Drug Discovery.
Ogasawara A; Torimoto N; Tsuda N; Aohara F; Ohashi R; Yamada Y; Taniguchi H
Drug Metab Lett; 2016; 10(3):152-160. PubMed ID: 27550199
[TBL] [Abstract][Full Text] [Related]
14. Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes.
Nishimura M; Koeda A; Suganuma Y; Suzuki E; Shimizu T; Nakayama M; Satoh T; Narimatsu S; Naito S
Drug Metab Pharmacokinet; 2007 Jun; 22(3):178-86. PubMed ID: 17603218
[TBL] [Abstract][Full Text] [Related]
15. Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+ -ATPase inhibitors and other xenobiotics.
Krusekopf S; Roots I; Hildebrandt AG; Kleeberg U
Xenobiotica; 2003 Feb; 33(2):107-18. PubMed ID: 12623754
[TBL] [Abstract][Full Text] [Related]
16. The comparative effects of diethyldithiocarbamate-copper complex with established proteasome inhibitors on expression levels of CYP1A2/3A4 and their master regulators, aryl hydrocarbon and pregnane X receptor in primary cultures of human hepatocytes.
Vrzal R; Dvorak Z
Fundam Clin Pharmacol; 2016 Dec; 30(6):585-595. PubMed ID: 27414036
[TBL] [Abstract][Full Text] [Related]
17. Farnesoid X Receptor Agonists Obeticholic Acid and Chenodeoxycholic Acid Increase Bile Acid Efflux in Sandwich-Cultured Human Hepatocytes: Functional Evidence and Mechanisms.
Guo C; LaCerte C; Edwards JE; Brouwer KR; Brouwer KLR
J Pharmacol Exp Ther; 2018 May; 365(2):413-421. PubMed ID: 29487110
[TBL] [Abstract][Full Text] [Related]
18. Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts.
Donato MT; Lahoz A; Jiménez N; Pérez G; Serralta A; Mir J; Castell JV; Gómez-Lechón MJ
Drug Metab Dispos; 2006 Sep; 34(9):1556-62. PubMed ID: 16763015
[TBL] [Abstract][Full Text] [Related]
19. Obeticholic acid protects mice against lipopolysaccharide-induced liver injury and inflammation.
Xiong X; Ren Y; Cui Y; Li R; Wang C; Zhang Y
Biomed Pharmacother; 2017 Dec; 96():1292-1298. PubMed ID: 29174575
[TBL] [Abstract][Full Text] [Related]
20. Anti-CD28 monoclonal antibody-stimulated cytokines released from blood suppress CYP1A2, CYP2B6, and CYP3A4 in human hepatocytes in vitro.
Czerwiński M; Kazmi F; Parkinson A; Buckley DB
Drug Metab Dispos; 2015 Jan; 43(1):42-52. PubMed ID: 25326287
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
