BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

530 related articles for article (PubMed ID: 31474573)

  • 1. Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
    Zhang H; Alsaleh G; Feltham J; Sun Y; Napolitano G; Riffelmacher T; Charles P; Frau L; Hublitz P; Yu Z; Mohammed S; Ballabio A; Balabanov S; Mellor J; Simon AK
    Mol Cell; 2019 Oct; 76(1):110-125.e9. PubMed ID: 31474573
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Polyamines reverse immune senescence via the translational control of autophagy.
    Zhang H; Simon AK
    Autophagy; 2020 Jan; 16(1):181-182. PubMed ID: 31679458
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
    Alsaleh G; Panse I; Swadling L; Zhang H; Richter FC; Meyer A; Lord J; Barnes E; Klenerman P; Green C; Simon AK
    Elife; 2020 Dec; 9():. PubMed ID: 33317695
    [TBL] [Abstract][Full Text] [Related]  

  • 4. eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
    Liang Y; Piao C; Beuschel CB; Toppe D; Kollipara L; Bogdanow B; Maglione M; Lützkendorf J; See JCK; Huang S; Conrad TOF; Kintscher U; Madeo F; Liu F; Sickmann A; Sigrist SJ
    Cell Rep; 2021 Apr; 35(2):108941. PubMed ID: 33852845
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The curious case of polyamines: spermidine drives reversal of B cell senescence.
    Metur SP; Klionsky DJ
    Autophagy; 2020 Mar; 16(3):389-390. PubMed ID: 31795807
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
    Oliverio S; Corazzari M; Sestito C; Piredda L; Ippolito G; Piacentini M
    Amino Acids; 2014 Dec; 46(12):2767-76. PubMed ID: 25218134
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.
    Schultz CR; Geerts D; Mooney M; El-Khawaja R; Koster J; Bachmann AS
    Biochem J; 2018 Jan; 475(2):531-545. PubMed ID: 29295892
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance.
    Choi UY; Lee JJ; Park A; Jung KL; Lee SA; Choi YJ; Lee HR; Lai CJ; Eoh H; Jung JU
    Cell Rep; 2022 Aug; 40(7):111234. PubMed ID: 35977517
    [TBL] [Abstract][Full Text] [Related]  

  • 9. AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
    Liao R; Chen X; Cao Q; Bai L; Ma C; Dai Z; Dong C
    Breast Cancer Res; 2024 Apr; 26(1):70. PubMed ID: 38654332
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
    Hyvönen MT; Keinänen TA; Khomutov M; Simonian A; Vepsäläinen J; Park JH; Khomutov AR; Alhonen L; Park MH
    Amino Acids; 2012 Feb; 42(2-3):685-95. PubMed ID: 21861168
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication.
    Olsen ME; Filone CM; Rozelle D; Mire CE; Agans KN; Hensley L; Connor JH
    mBio; 2016 Jul; 7(4):. PubMed ID: 27460797
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination.
    Turpaev K; Krizhanovskii C; Wang X; Sargsyan E; Bergsten P; Welsh N
    FASEB J; 2019 Mar; 33(3):3510-3522. PubMed ID: 30462531
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation.
    Landau G; Bercovich Z; Park MH; Kahana C
    J Biol Chem; 2010 Apr; 285(17):12474-81. PubMed ID: 20181941
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Differential Mechanisms for the Involvement of Polyamines and Hypusinated eIF5A in Ebola Virus Gene Expression.
    Olsen ME; Cressey TN; Mühlberger E; Connor JH
    J Virol; 2018 Oct; 92(20):. PubMed ID: 30045993
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.
    Zhou J; Pang J; Tripathi M; Ho JP; Widjaja AA; Shekeran SG; Cook SA; Suzuki A; Diehl AM; Petretto E; Singh BK; Yen PM
    Nat Commun; 2022 Sep; 13(1):5202. PubMed ID: 36057633
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging.
    Hofer SJ; Liang Y; Zimmermann A; Schroeder S; Dengjel J; Kroemer G; Eisenberg T; Sigrist SJ; Madeo F
    Autophagy; 2021 Aug; 17(8):2037-2039. PubMed ID: 34105442
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
    Hyvönen MT; Khomutov M; Petit M; Weisell J; Kochetkov SN; Alhonen L; Vepsäläinen J; Khomutov AR; Keinänen TA
    ACS Chem Biol; 2015 Jun; 10(6):1417-24. PubMed ID: 25689365
    [TBL] [Abstract][Full Text] [Related]  

  • 18. TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux.
    Zheng G; Pan Z; Zhan Y; Tang Q; Zheng F; Zhou Y; Wu Y; Zhou Y; Chen D; Chen J; Wang X; Gao W; Xu H; Tian N; Zhang X
    Osteoarthritis Cartilage; 2019 Feb; 27(2):347-357. PubMed ID: 30414849
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development.
    Padgett LR; Robertson MA; Anderson-Baucum EK; Connors CT; Wu W; Mirmira RG; Mastracci TL
    FASEB J; 2021 May; 35(5):e21473. PubMed ID: 33811703
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
    Puleston DJ; Buck MD; Klein Geltink RI; Kyle RL; Caputa G; O'Sullivan D; Cameron AM; Castoldi A; Musa Y; Kabat AM; Zhang Y; Flachsmann LJ; Field CS; Patterson AE; Scherer S; Alfei F; Baixauli F; Austin SK; Kelly B; Matsushita M; Curtis JD; Grzes KM; Villa M; Corrado M; Sanin DE; Qiu J; Pällman N; Paz K; Maccari ME; Blazar BR; Mittler G; Buescher JM; Zehn D; Rospert S; Pearce EJ; Balabanov S; Pearce EL
    Cell Metab; 2019 Aug; 30(2):352-363.e8. PubMed ID: 31130465
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.