BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

700 related articles for article (PubMed ID: 31485071)

  • 1. Structural basis of nucleosome recognition and modification by MLL methyltransferases.
    Xue H; Yao T; Cao M; Zhu G; Li Y; Yuan G; Chen Y; Lei M; Huang J
    Nature; 2019 Sep; 573(7774):445-449. PubMed ID: 31485071
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
    Patel A; Vought VE; Swatkoski S; Viggiano S; Howard B; Dharmarajan V; Monteith KE; Kupakuwana G; Namitz KE; Shinsky SA; Cotter RJ; Cosgrove MS
    J Biol Chem; 2014 Jan; 289(2):868-84. PubMed ID: 24235145
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis for activity regulation of MLL family methyltransferases.
    Li Y; Han J; Zhang Y; Cao F; Liu Z; Li S; Wu J; Hu C; Wang Y; Shuai J; Chen J; Cao L; Li D; Shi P; Tian C; Zhang J; Dou Y; Li G; Chen Y; Lei M
    Nature; 2016 Feb; 530(7591):447-52. PubMed ID: 26886794
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
    Park SH; Ayoub A; Lee YT; Xu J; Kim H; Zheng W; Zhang B; Sha L; An S; Zhang Y; Cianfrocco MA; Su M; Dou Y; Cho US
    Nat Commun; 2019 Dec; 10(1):5540. PubMed ID: 31804488
    [TBL] [Abstract][Full Text] [Related]  

  • 5. An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
    Cao F; Chen Y; Cierpicki T; Liu Y; Basrur V; Lei M; Dou Y
    PLoS One; 2010 Nov; 5(11):e14102. PubMed ID: 21124902
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.
    Kaustov L; Lemak A; Wu H; Faini M; Fan L; Fang X; Zeng H; Duan S; Allali-Hassani A; Li F; Wei Y; Vedadi M; Aebersold R; Wang Y; Houliston S; Arrowsmith CH
    Nucleic Acids Res; 2019 Sep; 47(17):9433-9447. PubMed ID: 31400120
    [TBL] [Abstract][Full Text] [Related]  

  • 7. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A; Dharmarajan V; Vought VE; Cosgrove MS
    J Biol Chem; 2009 Sep; 284(36):24242-56. PubMed ID: 19556245
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.
    Shinsky SA; Hu M; Vought VE; Ng SB; Bamshad MJ; Shendure J; Cosgrove MS
    J Mol Biol; 2014 Jun; 426(12):2283-99. PubMed ID: 24680668
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
    Rahman S; Hoffmann NA; Worden EJ; Smith ML; Namitz KEW; Knutson BA; Cosgrove MS; Wolberger C
    Proc Natl Acad Sci U S A; 2022 Sep; 119(38):e2205691119. PubMed ID: 36095189
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.
    Shinsky SA; Cosgrove MS
    J Biol Chem; 2015 Oct; 290(43):25819-33. PubMed ID: 26324722
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A; Vought VE; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2011 Feb; 286(5):3359-69. PubMed ID: 21106533
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
    Shinsky SA; Monteith KE; Viggiano S; Cosgrove MS
    J Biol Chem; 2015 Mar; 290(10):6361-75. PubMed ID: 25561738
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
    Alicea-Velázquez NL; Shinsky SA; Loh DM; Lee JH; Skalnik DG; Cosgrove MS
    J Biol Chem; 2016 Oct; 291(43):22357-22372. PubMed ID: 27563068
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.
    Jang S; Kang C; Yang HS; Jung T; Hebert H; Chung KY; Kim SJ; Hohng S; Song JJ
    Genes Dev; 2019 Jun; 33(11-12):620-625. PubMed ID: 30923167
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes.
    Zheng Y; Huang Y; Mencius J; Li Y; Zhao L; Luo W; Chen Y; Quan S
    J Biol Chem; 2021; 296():100635. PubMed ID: 33823156
    [TBL] [Abstract][Full Text] [Related]  

  • 16. H2B ubiquitylation enhances H3K4 methylation activities of human KMT2 family complexes.
    Kwon M; Park K; Hyun K; Lee JH; Zhou L; Cho YW; Ge K; Skalnik DG; Muir TW; Kim J
    Nucleic Acids Res; 2020 Jun; 48(10):5442-5456. PubMed ID: 32365172
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
    Dharmarajan V; Lee JH; Patel A; Skalnik DG; Cosgrove MS
    J Biol Chem; 2012 Aug; 287(33):27275-89. PubMed ID: 22665483
    [TBL] [Abstract][Full Text] [Related]  

  • 18. ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes.
    Wu L; Lee SY; Zhou B; Nguyen UT; Muir TW; Tan S; Dou Y
    Mol Cell; 2013 Mar; 49(6):1108-20. PubMed ID: 23453805
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of MLL1 H3K4 methyltransferase activity by its core components.
    Dou Y; Milne TA; Ruthenburg AJ; Lee S; Lee JW; Verdine GL; Allis CD; Roeder RG
    Nat Struct Mol Biol; 2006 Aug; 13(8):713-9. PubMed ID: 16878130
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.
    Han J; Li T; Li Y; Li M; Wang X; Peng C; Su C; Li N; Li Y; Xu Y; Chen Y
    Nucleic Acids Res; 2019 Nov; 47(19):10426-10438. PubMed ID: 31544921
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 35.