BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 31487813)

  • 1. Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors.
    Al-Balas QA; Al-Smadi ML; Hassan MA; Al Jabal GA; Almaaytah AM; Alzoubi KH
    Molecules; 2019 Sep; 24(18):. PubMed ID: 31487813
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of a nanomolar inhibitor of the human glyoxalase-I enzyme using structure-based poly-pharmacophore modelling and molecular docking.
    Al-Shar'i NA; Al-Balas QA; Al-Waqfi RA; Hassan MA; Alkhalifa AE; Ayoub NM
    J Comput Aided Mol Des; 2019 Sep; 33(9):799-815. PubMed ID: 31630312
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evaluation of potential flavonoid inhibitors of glyoxalase-I based on virtual screening and in vitro studies.
    Yadav A; Kumar R; Sunkaria A; Singhal N; Kumar M; Sandhir R
    J Biomol Struct Dyn; 2016 May; 34(5):993-1007. PubMed ID: 26108947
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel glyoxalase-I inhibitors possessing a "zinc-binding feature" as potential anticancer agents.
    Al-Balas QA; Hassan MA; Al-Shar'i NA; Mhaidat NM; Almaaytah AM; Al-Mahasneh FM; Isawi IH
    Drug Des Devel Ther; 2016; 10():2623-9. PubMed ID: 27574401
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold.
    Al-Shar'i NA; Al-Balas QA; Hassan MA; El-Elimat TM; Aljabal GA; Almaaytah AM
    Acta Pharm; 2021 Mar; 71(1):115-130. PubMed ID: 32697740
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents.
    Al-Oudat BA; Jaradat HM; Al-Balas QA; Al-Shar'i NA; Bryant-Friedrich A; Bedi MF
    Bioorg Med Chem; 2020 Aug; 28(16):115608. PubMed ID: 32690268
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents.
    Al-Sha'er MA; Al-Balas QA; Hassan MA; Al Jabal GA; Almaaytah AM
    Comput Biol Chem; 2019 Jun; 80():102-110. PubMed ID: 30947068
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies.
    Yuan M; Luo M; Song Y; Xu Q; Wang X; Cao Y; Bu X; Ren Y; Hu X
    Bioorg Med Chem; 2011 Feb; 19(3):1189-96. PubMed ID: 21237663
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel anthraquinone amide derivatives as potential glyoxalase-I inhibitors.
    Al-Akeedi M; Najdawi M; Al-Balas Q; Al-Qazzan MB; Telfah ST
    J Med Life; 2024 Jan; 17(1):87-98. PubMed ID: 38737655
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Combined High Throughput Screening with QSAR Analysis Unravelling Potential Glyoxalase-I Inhibitors.
    Al-Sha'er MA; Al-Balas QA; Hassan MA
    Curr Comput Aided Drug Des; 2020; 16(6):814-832. PubMed ID: 31957614
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Computational and experimental exploration of the structure-activity relationships of flavonoids as potent glyoxalase-I inhibitors.
    Al-Balas QA; Hassan MA; Al-Shar'i NA; El-Elimat T; Almaaytah AM
    Drug Dev Res; 2018 Mar; 79(2):58-69. PubMed ID: 29285772
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lead optimization and biological evaluation of diazenylbenzenesulfonamides inhibitors against glyoxalase-I enzyme as potential anticancer agents.
    Al-Oudat BA; Al-Shar'i NA; Al-Balas QA; Audat SA; Alqudah MAY; Hamzah AH; Hallak RW; Bedi M; Bryant-Friedrich A
    Bioorg Chem; 2022 Mar; 120():105657. PubMed ID: 35152183
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular docking and dynamic studies of a potential therapeutic target inhibiting glyoxalase system: Metabolic action of the 3, 3 '- [3- (5-chloro-2-hydroxyphenyl) -3-oxopropane-1, 1-diyl] - Bis-4-hydroxycoumarin leads overexpression of the intracellular level of methylglyoxal and induction of a pro-apoptotic phenomenon in a hepatocellular carcinoma model.
    Taïbi N; Al-Balas QA; Bekari N; Talhi O; Al Jabal GA; Benali Y; Ameraoui R; Hadjadj M; Taïbi A; Boutaiba ZM; Abou-Mustapha M; Khammar F; Dergal F; Hassaine R; Boukenna L; Bachari K; Soares Silva AM
    Chem Biol Interact; 2021 Aug; 345():109511. PubMed ID: 33989593
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Generation of the first structure-based pharmacophore model containing a selective "zinc binding group" feature to identify potential glyoxalase-1 inhibitors.
    Al-Balas Q; Hassan M; Al-Oudat B; Alzoubi H; Mhaidat N; Almaaytah A
    Molecules; 2012 Nov; 17(12):13740-58. PubMed ID: 23174893
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Addition of hydrophobic side chains improve the apoptosis inducibility of the human glyoxalase I inhibitor, TLSC702.
    Azuma M; Inoue M; Nishida A; Akahane H; Kitajima M; Natani S; Chimori R; Yoshimori A; Mano Y; Uchiro H; Tanuma SI; Takasawa R
    Bioorg Med Chem Lett; 2021 May; 40():127918. PubMed ID: 33711442
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I.
    Takasawa R; Saeki K; Tao A; Yoshimori A; Uchiro H; Fujiwara M; Tanuma S
    Bioorg Med Chem; 2010 Oct; 18(19):7029-33. PubMed ID: 20801663
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Recent Advances in Glyoxalase-I Inhibition.
    Al-Balas QA; Hassan MA; Al-Shar'i NA; Al Jabal GA; Almaaytah AM
    Mini Rev Med Chem; 2019; 19(4):281-291. PubMed ID: 30306863
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Piceatannol, a natural trans-stilbene compound, inhibits human glyoxalase I.
    Takasawa R; Akahane H; Tanaka H; Shimada N; Yamamoto T; Uchida-Maruki H; Sai M; Yoshimori A; Tanuma SI
    Bioorg Med Chem Lett; 2017 Mar; 27(5):1169-1174. PubMed ID: 28169168
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors.
    Audat SA; Al-Balas QA; Al-Oudat BA; Athamneh MJ; Bryant-Friedrich A
    Drug Des Devel Ther; 2022; 16():873-885. PubMed ID: 35378924
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel bivalent inhibitors with sub-nanomolar affinities towards human glyoxalase I.
    Sang Y; Shi Q; Mo M; Ni C; Li Z; Liu B; Deng Q; Creighton DJ; Zheng ZB
    Bioorg Med Chem Lett; 2015 Nov; 25(21):4724-4727. PubMed ID: 26320622
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.