BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 31488542)

  • 1. Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450.
    DeMars MD; Samora NL; Yang S; Garcia-Borràs M; Sanders JN; Houk KN; Podust LM; Sherman DH
    J Biol Chem; 2019 Nov; 294(44):15947-15961. PubMed ID: 31488542
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.
    DeMars MD; Sheng F; Park SR; Lowell AN; Podust LM; Sherman DH
    ACS Chem Biol; 2016 Sep; 11(9):2642-54. PubMed ID: 27420774
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions.
    Li S; Tietz DR; Rutaganira FU; Kells PM; Anzai Y; Kato F; Pochapsky TC; Sherman DH; Podust LM
    J Biol Chem; 2012 Nov; 287(45):37880-90. PubMed ID: 22952225
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s.
    Amaya JA; Lamb DC; Kelly SL; Caffrey P; Murarka VC; Poulos TL
    J Biol Chem; 2022 Apr; 298(4):101746. PubMed ID: 35189143
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics.
    Anzai Y; Li S; Chaulagain MR; Kinoshita K; Kato F; Montgomery J; Sherman DH
    Chem Biol; 2008 Sep; 15(9):950-9. PubMed ID: 18804032
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems.
    Podust LM; Kim Y; Arase M; Neely BA; Beck BJ; Bach H; Sherman DH; Lamb DC; Kelly SL; Waterman MR
    J Biol Chem; 2003 Apr; 278(14):12214-21. PubMed ID: 12519772
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.
    Sherman DH; Li S; Yermalitskaya LV; Kim Y; Smith JA; Waterman MR; Podust LM
    J Biol Chem; 2006 Sep; 281(36):26289-97. PubMed ID: 16825192
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin.
    Anzai Y; Tsukada S; Sakai A; Masuda R; Harada C; Domeki A; Li S; Kinoshita K; Sherman DH; Kato F
    Antimicrob Agents Chemother; 2012 Jul; 56(7):3648-56. PubMed ID: 22547618
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways.
    Podust LM; Bach H; Kim Y; Lamb DC; Arase M; Sherman DH; Kelly SL; Waterman MR
    Protein Sci; 2004 Jan; 13(1):255-68. PubMed ID: 14691240
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium.
    Jóźwik IK; Kiss FM; Gricman Ł; Abdulmughni A; Brill E; Zapp J; Pleiss J; Bernhardt R; Thunnissen AW
    FEBS J; 2016 Nov; 283(22):4128-4148. PubMed ID: 27686671
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics.
    Yang S; DeMars MD; Grandner JM; Olson NM; Anzai Y; Sherman DH; Houk KN
    J Am Chem Soc; 2020 Oct; 142(42):17981-17988. PubMed ID: 33030347
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.
    Gustafsson MC; Roitel O; Marshall KR; Noble MA; Chapman SK; Pessegueiro A; Fulco AJ; Cheesman MR; von Wachenfeldt C; Munro AW
    Biochemistry; 2004 May; 43(18):5474-87. PubMed ID: 15122913
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus.
    Kim V; Lim YR; Lee I; Lee JH; Han S; Pham TV; Kim H; Lee R; Kang LW; Kim D
    Arch Biochem Biophys; 2020 Oct; 692():108544. PubMed ID: 32822639
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.
    Tietz DR; Podust LM; Sherman DH; Pochapsky TC
    Biochemistry; 2017 May; 56(21):2701-2714. PubMed ID: 28488849
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis.
    Xu LH; Fushinobu S; Takamatsu S; Wakagi T; Ikeda H; Shoun H
    J Biol Chem; 2010 May; 285(22):16844-53. PubMed ID: 20375018
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids.
    Pan Y; Li G; Liu R; Guo J; Liu Y; Liu M; Zhang X; Chi L; Xu K; Wu R; Zhang Y; Li Y; Gao X; Li S
    Nat Commun; 2023 Mar; 14(1):1669. PubMed ID: 36966128
    [TBL] [Abstract][Full Text] [Related]  

  • 17. New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.
    Zhang W; Liu Y; Yan J; Cao S; Bai F; Yang Y; Huang S; Yao L; Anzai Y; Kato F; Podust LM; Sherman DH; Li S
    J Am Chem Soc; 2014 Mar; 136(9):3640-6. PubMed ID: 24521145
    [TBL] [Abstract][Full Text] [Related]  

  • 18. What Your Crystal Structure Will Not Tell You about Enzyme Function.
    Pochapsky TC; Pochapsky SS
    Acc Chem Res; 2019 May; 52(5):1409-1418. PubMed ID: 31034199
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.
    Rudolf JD; Chang CY; Ma M; Shen B
    Nat Prod Rep; 2017 Aug; 34(9):1141-1172. PubMed ID: 28758170
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular Dynamics Simulations of a Cytochrome P450 from
    Faponle AS; Roy A; Adelegan AA; Gauld JW
    Molecules; 2021 Jun; 26(12):. PubMed ID: 34204747
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.