BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

367 related articles for article (PubMed ID: 31502692)

  • 1. Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters.
    Cheung KWK; van Groen BD; Burckart GJ; Zhang L; de Wildt SN; Huang SM
    J Clin Pharmacol; 2019 Sep; 59 Suppl 1(Suppl 1):S56-S69. PubMed ID: 31502692
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Application of Physiologically Based Pharmacokinetic Modeling to Predict the Role of Drug Transporters: Scientific and Regulatory Perspectives.
    Pan Y; Hsu V; Grimstein M; Zhang L; Arya V; Sinha V; Grillo JA; Zhao P
    J Clin Pharmacol; 2016 Jul; 56 Suppl 7():S122-31. PubMed ID: 27385170
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Potential implications of DMET ontogeny on the disposition of commonly prescribed drugs in neonatal and pediatric intensive care units.
    Naji-Talakar S; Sharma S; Martin LA; Barnhart D; Prasad B
    Expert Opin Drug Metab Toxicol; 2021 Mar; 17(3):273-289. PubMed ID: 33256492
    [No Abstract]   [Full Text] [Related]  

  • 4. Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
    Verscheijden LFM; Koenderink JB; Johnson TN; de Wildt SN; Russel FGM
    Pharmacol Ther; 2020 Jul; 211():107541. PubMed ID: 32246949
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Predictive Pediatric Modeling and Simulation Using Ontogeny Information.
    Ince I; Solodenko J; Frechen S; Dallmann A; Niederalt C; Schlender J; Burghaus R; Lippert J; Willmann S
    J Clin Pharmacol; 2019 Sep; 59 Suppl 1():S95-S103. PubMed ID: 31502689
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics.
    Elmorsi Y; Barber J; Rostami-Hodjegan A
    Drug Metab Dispos; 2016 Jul; 44(7):992-8. PubMed ID: 26712821
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
    Brouwer KL; Aleksunes LM; Brandys B; Giacoia GP; Knipp G; Lukacova V; Meibohm B; Nigam SK; Rieder M; de Wildt SN;
    Clin Pharmacol Ther; 2015 Sep; 98(3):266-87. PubMed ID: 26088472
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.
    Johnson TN; Rostami-Hodjegan A
    Paediatr Anaesth; 2011 Mar; 21(3):291-301. PubMed ID: 20497354
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Summary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group.
    Abdel-Rahman SM; Amidon GL; Kaul A; Lukacova V; Vinks AA; Knipp GT;
    Clin Ther; 2012 Nov; 34(11):S11-24. PubMed ID: 23149009
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.
    Li CY; Hosey-Cojocari C; Basit A; Unadkat JD; Leeder JS; Prasad B
    AAPS J; 2019 Jul; 21(5):88. PubMed ID: 31297641
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?
    Johnson TN; Ke AB
    J Clin Pharmacol; 2021 Jun; 61 Suppl 1():S83-S93. PubMed ID: 34185901
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Physiologically-based Pharmacokinetic (PBPK) Modelling of Transporter Mediated Drug Absorption, Clearance and Drug-drug Interactions.
    Taskar KS; Harada I; Alluri RV
    Curr Drug Metab; 2021; 22(7):523-531. PubMed ID: 33397250
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species.
    van Groen BD; Nicolaï J; Kuik AC; Van Cruchten S; van Peer E; Smits A; Schmidt S; de Wildt SN; Allegaert K; De Schaepdrijver L; Annaert P; Badée J
    Pharmacol Rev; 2021 Apr; 73(2):597-678. PubMed ID: 33608409
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study.
    Cristea S; Krekels EHJ; Rostami-Hodjegan A; Allegaert K; Knibbe CAJ
    AAPS J; 2020 Jun; 22(4):87. PubMed ID: 32566984
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children.
    Zhou W; Johnson TN; Xu H; Cheung S; Bui KH; Li J; Al-Huniti N; Zhou D
    CPT Pharmacometrics Syst Pharmacol; 2016 Sep; 5(9):475-83. PubMed ID: 27566992
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The use of PBPK modeling across the pediatric age range using propofol as a case.
    Michelet R; Van Bocxlaer J; Allegaert K; Vermeulen A
    J Pharmacokinet Pharmacodyn; 2018 Dec; 45(6):765-785. PubMed ID: 30298439
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism.
    Fan J; Chen S; Chow EC; Pang KS
    Curr Drug Metab; 2010 Nov; 11(9):743-61. PubMed ID: 21189137
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Model qualification of the PK-Sim® pediatric module for pediatric exposure assessment of CYP450 metabolized compounds.
    Yun YE; Edginton AN
    J Toxicol Environ Health A; 2019; 82(14):789-814. PubMed ID: 31405354
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3.
    Cristea S; Krekels EHJ; Allegaert K; De Paepe P; de Jaeger A; De Cock P; Knibbe CAJ
    AAPS J; 2021 May; 23(3):65. PubMed ID: 33948771
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Prediction of Clearance in Neonates and Infants (≤ 3 Months of Age) for Drugs That Are Glucuronidated: A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling.
    Mahmood I; Ahmad T; Mansoor N; Sharib SM
    J Clin Pharmacol; 2017 Apr; 57(4):476-483. PubMed ID: 27704554
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.