BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

311 related articles for article (PubMed ID: 31520353)

  • 1. Understanding Obesity as a Risk Factor for Uterine Tumors Using Drosophila.
    Li X; Liu M; Ji JY
    Adv Exp Med Biol; 2019; 1167():129-155. PubMed ID: 31520353
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    Park MJ; Shen H; Spaeth JM; Tolvanen JH; Failor C; Knudtson JF; McLaughlin J; Halder SK; Yang Q; Bulun SE; Al-Hendy A; Schenken RS; Aaltonen LA; Boyer TG
    J Biol Chem; 2018 Mar; 293(13):4870-4882. PubMed ID: 29440396
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas.
    Mäkinen N; Heinonen HR; Sjöberg J; Taipale J; Vahteristo P; Aaltonen LA
    Br J Cancer; 2014 Apr; 110(9):2246-9. PubMed ID: 24642626
    [TBL] [Abstract][Full Text] [Related]  

  • 4. De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.
    Calpena E; Hervieu A; Kaserer T; Swagemakers SMA; Goos JAC; Popoola O; Ortiz-Ruiz MJ; Barbaro-Dieber T; Bownass L; Brilstra EH; Brimble E; Foulds N; Grebe TA; Harder AVE; Lees MM; Monaghan KG; Newbury-Ecob RA; Ong KR; Osio D; Reynoso Santos FJ; Ruzhnikov MRZ; Telegrafi A; van Binsbergen E; van Dooren MF; ; van der Spek PJ; Blagg J; Twigg SRF; Mathijssen IMJ; Clarke PA; Wilkie AOM
    Am J Hum Genet; 2019 Apr; 104(4):709-720. PubMed ID: 30905399
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
    Gobert V; Osman D; Bras S; Augé B; Boube M; Bourbon HM; Horn T; Boutros M; Haenlin M; Waltzer L
    Mol Cell Biol; 2010 Jun; 30(11):2837-48. PubMed ID: 20368357
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
    Kämpjärvi K; Kim NH; Keskitalo S; Clark AD; von Nandelstadh P; Turunen M; Heikkinen T; Park MJ; Mäkinen N; Kivinummi K; Lintula S; Hotakainen K; Nevanlinna H; Hokland P; Böhling T; Bützow R; Böhm J; Mecklin JP; Järvinen H; Kontro M; Visakorpi T; Taipale J; Varjosalo M; Boyer TG; Vahteristo P
    Prostate; 2016 Jan; 76(1):22-31. PubMed ID: 26383637
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.
    Kuuluvainen E; Hakala H; Havula E; Sahal Estimé M; Rämet M; Hietakangas V; Mäkelä TP
    J Biol Chem; 2014 Jun; 289(23):16252-61. PubMed ID: 24778181
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells.
    Kuuluvainen E; Domènech-Moreno E; Niemelä EH; Mäkelä TP
    Mol Cell Biol; 2018 Jun; 38(11):. PubMed ID: 29507187
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.
    Klatt F; Leitner A; Kim IV; Ho-Xuan H; Schneider EV; Langhammer F; Weinmann R; Müller MR; Huber R; Meister G; Kuhn CD
    Proc Natl Acad Sci U S A; 2020 Feb; 117(6):2894-2905. PubMed ID: 31988137
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.
    Broude EV; Győrffy B; Chumanevich AA; Chen M; McDermott MS; Shtutman M; Catroppo JF; Roninson IB
    Curr Cancer Drug Targets; 2015; 15(8):739-49. PubMed ID: 26452386
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cyclin-dependent kinase 8 is an independent prognosticator in uterine leiomyosarcoma.
    Yasutake N; Iwasaki T; Yamamoto H; Sonoda K; Kodama K; Okugawa K; Asanoma K; Yahata H; Kato K; Oda Y
    Pathol Res Pract; 2022 Jul; 235():153920. PubMed ID: 35605413
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Distinct roles for Mediator Cdk8 module subunits in Drosophila development.
    Loncle N; Boube M; Joulia L; Boschiero C; Werner M; Cribbs DL; Bourbon HM
    EMBO J; 2007 Feb; 26(4):1045-54. PubMed ID: 17290221
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dysregulation of CDK8 and Cyclin C in tumorigenesis.
    Xu W; Ji JY
    J Genet Genomics; 2011 Oct; 38(10):439-52. PubMed ID: 22035865
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer.
    Voutsadakis IA
    Pharmacol Rep; 2024 Apr; ():. PubMed ID: 38602606
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Distinct effects of CDK8 module subunits on cellular growth and proliferation in
    Li X; Liu M; Xing Y; Niu Y; Liu TH; Sun JL; Liu Y; Hemba-Waduge RU; Ji JY
    bioRxiv; 2024 May; ():. PubMed ID: 38746212
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
    Brägelmann J; Klümper N; Offermann A; von Mässenhausen A; Böhm D; Deng M; Queisser A; Sanders C; Syring I; Merseburger AS; Vogel W; Sievers E; Vlasic I; Carlsson J; Andrén O; Brossart P; Duensing S; Svensson MA; Adler D; Kirfel J; Perner S
    Clin Cancer Res; 2017 Apr; 23(7):1829-1840. PubMed ID: 27678455
    [No Abstract]   [Full Text] [Related]  

  • 17. An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.
    Chen J; Ezzeddine N; Waltenspiel B; Albrecht TR; Warren WD; Marzluff WF; Wagner EJ
    RNA; 2012 Dec; 18(12):2148-56. PubMed ID: 23097424
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.
    Belakavadi M; Fondell JD
    Mol Cell Biol; 2010 May; 30(10):2437-48. PubMed ID: 20231357
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mediator kinase module and human tumorigenesis.
    Clark AD; Oldenbroek M; Boyer TG
    Crit Rev Biochem Mol Biol; 2015; 50(5):393-426. PubMed ID: 26182352
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.
    Commandeur AE; Styer AK; Teixeira JM
    Hum Reprod Update; 2015; 21(5):593-615. PubMed ID: 26141720
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.