BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 31520592)

  • 1. Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP.
    Sobich J; Prokopowicz M; Maj P; Wilk P; Zieliński Z; Frączyk T; Rode W
    Arch Biochem Biophys; 2019 Oct; 674():108106. PubMed ID: 31520592
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular Mechanism of Thymidylate Synthase Inhibition by N
    Maj P; Jarmuła A; Wilk P; Prokopowicz M; Rypniewski W; Zieliński Z; Dowierciał A; Bzowska A; Rode W
    Int J Mol Sci; 2021 Apr; 22(9):. PubMed ID: 33946210
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.
    Matthews DA; Villafranca JE; Janson CA; Smith WW; Welsh K; Freer S
    J Mol Biol; 1990 Aug; 214(4):937-48. PubMed ID: 2201779
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase.
    van der Wilt CL; Pinedo HM; de Jong M; Peters GJ
    Biochem Pharmacol; 1993 Mar; 45(5):1177-9. PubMed ID: 8461049
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
    Felczak K; Miazga A; Poznański J; Bretner M; Kulikowski T; Dzik JM; Gołos B; Zieliński Z; Cieśla J; Rode W
    J Med Chem; 2000 Nov; 43(24):4647-56. PubMed ID: 11101356
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogues.
    Rode W; Zieliński Z; Dzik JM; Kulikowski T; Bretner M; Kierdaszuk B; Cieśla J; Shugar D
    Biochemistry; 1990 Dec; 29(48):10835-42. PubMed ID: 2271682
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate.
    Pellino AM; Danenberg PV
    J Biol Chem; 1985 Sep; 260(20):10996-1000. PubMed ID: 3928628
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues.
    Prokopowicz M; Jarmuła A; Casamayou-Boucau Y; Gordon F; Ryder A; Sobich J; Maj P; Cieśla J; Zieliński Z; Fita P; Rode W
    Int J Mol Sci; 2021 Mar; 22(5):. PubMed ID: 33800923
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Studies of 5-fluorodeoxyuridine 5'-monophosphate binding to carboxypeptidase A-inactivated thymidylate synthase from Lactobacillus casei.
    Cisneros RJ; Zapf JW; Dunlap RB
    J Biol Chem; 1993 May; 268(14):10102-8. PubMed ID: 8486679
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N(4)-hydroxy-dCMP.
    Ludwiczak J; Maj P; Wilk P; Frączyk T; Ruman T; Kierdaszuk B; Jarmuła A; Rode W
    Mol Biosyst; 2016 Apr; 12(4):1333-41. PubMed ID: 26916840
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
    Houghton JA; Schmidt C; Houghton PJ
    Eur J Cancer Clin Oncol; 1982 Apr; 18(4):347-54. PubMed ID: 6889511
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft.
    Radparvar S; Houghton PJ; Houghton JA
    Biochem Pharmacol; 1989 Jan; 38(2):335-42. PubMed ID: 2914018
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.
    Spears CP; Hayes AA; Shahinian AH; Danenberg PV; Frösing R; Gustavsson BG
    Biochem Pharmacol; 1989 Sep; 38(18):2985-93. PubMed ID: 2783153
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Properties of a defined mutant of Escherichia coli thymidylate synthase.
    Maley GF; Maley F
    J Biol Chem; 1988 Jun; 263(16):7620-7. PubMed ID: 3286637
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evaluation of folylpolyglutamates by electrophoretic separation of fluorodeoxyuridylate-thymidylate synthase-methylenetetrahydrofolate complexes.
    Priest DG; Doig MT
    Adv Exp Med Biol; 1983; 163():139-48. PubMed ID: 6412520
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates.
    Moore MA; Ahmed F; Dunlap RB
    J Biol Chem; 1986 Sep; 261(27):12745-9. PubMed ID: 3745210
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.
    Garvey EP; Santi DV
    J Biol Chem; 1987 Jul; 262(19):9068-74. PubMed ID: 3597407
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
    Atreya CE; Johnson EF; Williamson J; Chang SY; Liang PH; Anderson KS
    J Biol Chem; 2003 Aug; 278(31):28901-11. PubMed ID: 12754260
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
    Connick TJ; Reilly RT; Dunlap RB; Ellis PD
    Biochim Biophys Acta; 1994 Sep; 1208(1):118-26. PubMed ID: 8086425
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate.
    Keyomarsi K; Moran RG
    J Biol Chem; 1990 Nov; 265(31):19163-9. PubMed ID: 2146271
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.