These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 31521478)

  • 1. Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase.
    Watkins SM; Ghose D; Blain JM; Grote DL; Luan CH; Clare M; Meganathan R; Horn JR; Hagen TJ
    Bioorg Med Chem Lett; 2019 Oct; 29(20):126660. PubMed ID: 31521478
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structure of IspF from
    Liu Z; Jin Y; Liu W; Tao Y; Wang G
    Biosci Rep; 2018 Feb; 38(1):. PubMed ID: 29335298
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment.
    O'Rourke PE; Kalinowska-Tłuścik J; Fyfe PK; Dawson A; Hunter WN
    BMC Struct Biol; 2014 Jan; 14():1. PubMed ID: 24410837
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity.
    Bitok JK; Meyers CF
    ACS Chem Biol; 2012 Oct; 7(10):1702-10. PubMed ID: 22839733
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei.
    Zhang Z; Jakkaraju S; Blain J; Gogol K; Zhao L; Hartley RC; Karlsson CA; Staker BL; Edwards TE; Stewart LJ; Myler PJ; Clare M; Begley DW; Horn JR; Hagen TJ
    Bioorg Med Chem Lett; 2013 Dec; 23(24):6860-3. PubMed ID: 24157367
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF.
    Narayanasamy P; Eoh H; Brennan PJ; Crick DC
    Chem Biol; 2010 Feb; 17(2):117-22. PubMed ID: 20189102
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate.
    Blain JM; Grote DL; Watkins SM; Goshu GM; Muller C; Gorman JL; Ranieri G; Walter RL; Hofstetter H; Horn JR; Hagen TJ
    Bioorg Med Chem Lett; 2021 Sep; 48():128273. PubMed ID: 34298132
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum.
    Singh VK; Ghosh I
    FEBS Lett; 2013 Sep; 587(17):2806-17. PubMed ID: 23816706
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis.
    Gabrielsen M; Bond CS; Hallyburton I; Hecht S; Bacher A; Eisenreich W; Rohdich F; Hunter WN
    J Biol Chem; 2004 Dec; 279(50):52753-61. PubMed ID: 15466439
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development.
    Kemp LE; Bond CS; Hunter WN
    Proc Natl Acad Sci U S A; 2002 May; 99(10):6591-6. PubMed ID: 11997478
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum.
    Rohdich F; Eisenreich W; Wungsintaweekul J; Hecht S; Schuhr CA; Bacher A
    Eur J Biochem; 2001 Jun; 268(11):3190-7. PubMed ID: 11389720
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.
    Steinbacher S; Kaiser J; Wungsintaweekul J; Hecht S; Eisenreich W; Gerhardt S; Bacher A; Rohdich F
    J Mol Biol; 2002 Feb; 316(1):79-88. PubMed ID: 11829504
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
    Begley DW; Hartley RC; Davies DR; Edwards TE; Leonard JT; Abendroth J; Burris CA; Bhandari J; Myler PJ; Staker BL; Stewart LJ
    J Struct Funct Genomics; 2011 Jul; 12(2):63-76. PubMed ID: 21359640
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery.
    Buetow L; Brown AC; Parish T; Hunter WN
    BMC Struct Biol; 2007 Oct; 7():68. PubMed ID: 17956607
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active site.
    Harmer NJ
    J Mol Biol; 2010 Jul; 400(3):379-92. PubMed ID: 20447408
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy.
    Ramsden NL; Buetow L; Dawson A; Kemp LA; Ulaganathan V; Brenk R; Klebe G; Hunter WN
    J Med Chem; 2009 Apr; 52(8):2531-42. PubMed ID: 19320487
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular cloning, characterization and functional analysis of a 2C-methyl- D-erythritol 2, 4-cyclodiphosphate synthase gene from ginkgo biloba.
    Gao S; Lin J; Liu X; Deng Z; Li Y; Sun X; Tang K
    J Biochem Mol Biol; 2006 Sep; 39(5):502-10. PubMed ID: 17002869
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
    Richard SB; Ferrer JL; Bowman ME; Lillo AM; Tetzlaff CN; Cane DE; Noel JP
    J Biol Chem; 2002 Mar; 277(10):8667-72. PubMed ID: 11786530
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate.
    Herz S; Wungsintaweekul J; Schuhr CA; Hecht S; Luttgen H; Sagner S; Fellermeier M; Eisenreich W; Zenk MH; Bacher A; Rohdich F
    Proc Natl Acad Sci U S A; 2000 Mar; 97(6):2486-90. PubMed ID: 10694574
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni.
    Gabrielsen M; Rohdich F; Eisenreich W; Gräwert T; Hecht S; Bacher A; Hunter WN
    Eur J Biochem; 2004 Jul; 271(14):3028-35. PubMed ID: 15233799
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.