191 related articles for article (PubMed ID: 31521622)
1. Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies.
Ravikumar B; Timonen S; Alam Z; Parri E; Wennerberg K; Aittokallio T
Cell Chem Biol; 2019 Nov; 26(11):1608-1622.e6. PubMed ID: 31521622
[TBL] [Abstract][Full Text] [Related]
2. A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Gao Y; Davies SP; Augustin M; Woodward A; Patel UA; Kovelman R; Harvey KJ
Biochem J; 2013 Apr; 451(2):313-28. PubMed ID: 23398362
[TBL] [Abstract][Full Text] [Related]
3. Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation.
Li X; Li Z; Wu X; Xiong Z; Yang T; Fu Z; Liu X; Tan X; Zhong F; Wan X; Wang D; Ding X; Yang R; Hou H; Li C; Liu H; Chen K; Jiang H; Zheng M
J Med Chem; 2020 Aug; 63(16):8723-8737. PubMed ID: 31364850
[TBL] [Abstract][Full Text] [Related]
4. Structure-Based Kinase Profiling To Understand the Polypharmacological Behavior of Therapeutic Molecules.
Dutta D; Das R; Mandal C; Mandal C
J Chem Inf Model; 2018 Jan; 58(1):68-89. PubMed ID: 29243930
[TBL] [Abstract][Full Text] [Related]
5. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
Wells CI; Al-Ali H; Andrews DM; Asquith CRM; Axtman AD; Dikic I; Ebner D; Ettmayer P; Fischer C; Frederiksen M; Futrell RE; Gray NS; Hatch SB; Knapp S; Lücking U; Michaelides M; Mills CE; Müller S; Owen D; Picado A; Saikatendu KS; Schröder M; Stolz A; Tellechea M; Turunen BJ; Vilar S; Wang J; Zuercher WJ; Willson TM; Drewry DH
Int J Mol Sci; 2021 Jan; 22(2):. PubMed ID: 33429995
[TBL] [Abstract][Full Text] [Related]
6. Systematic computational identification of promiscuity cliff pathways formed by inhibitors of the human kinome.
Miljković F; Vogt M; Bajorath J
J Comput Aided Mol Des; 2019 Jun; 33(6):559-572. PubMed ID: 30915709
[TBL] [Abstract][Full Text] [Related]
7. Analyzing Kinase Similarity in Small Molecule and Protein Structural Space to Explore the Limits of Multi-Target Screening.
Schmidt D; Scharf MM; Sydow D; Aßmann E; Martí-Solano M; Keul M; Volkamer A; Kolb P
Molecules; 2021 Jan; 26(3):. PubMed ID: 33530327
[TBL] [Abstract][Full Text] [Related]
8. Data structures for computational compound promiscuity analysis and exemplary applications to inhibitors of the human kinome.
Miljković F; Bajorath J
J Comput Aided Mol Des; 2020 Jan; 34(1):1-10. PubMed ID: 31792884
[TBL] [Abstract][Full Text] [Related]
9. Progress towards a public chemogenomic set for protein kinases and a call for contributions.
Drewry DH; Wells CI; Andrews DM; Angell R; Al-Ali H; Axtman AD; Capuzzi SJ; Elkins JM; Ettmayer P; Frederiksen M; Gileadi O; Gray N; Hooper A; Knapp S; Laufer S; Luecking U; Michaelides M; Müller S; Muratov E; Denny RA; Saikatendu KS; Treiber DK; Zuercher WJ; Willson TM
PLoS One; 2017; 12(8):e0181585. PubMed ID: 28767711
[TBL] [Abstract][Full Text] [Related]
10. The design, annotation, and application of a kinase-targeted library.
Xi H; Lunney EA
Methods Mol Biol; 2011; 685():279-91. PubMed ID: 20981529
[TBL] [Abstract][Full Text] [Related]
11. Mapping of inhibitors and activity data to the human kinome and exploring promiscuity from a ligand and target perspective.
Hu Y; Kunimoto R; Bajorath J
Chem Biol Drug Des; 2017 Jun; 89(6):834-845. PubMed ID: 27933727
[TBL] [Abstract][Full Text] [Related]
12. Kinome-Wide Profiling Prediction of Small Molecules.
Sorgenfrei FA; Fulle S; Merget B
ChemMedChem; 2018 Mar; 13(6):495-499. PubMed ID: 28544552
[TBL] [Abstract][Full Text] [Related]
13. Target-specific support vector machine scoring in structure-based virtual screening: computational validation, in vitro testing in kinases, and effects on lung cancer cell proliferation.
Li L; Khanna M; Jo I; Wang F; Ashpole NM; Hudmon A; Meroueh SO
J Chem Inf Model; 2011 Apr; 51(4):755-9. PubMed ID: 21438548
[TBL] [Abstract][Full Text] [Related]
14. Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome-Inhibitor Interaction Landscapes.
Janssen APA; Grimm SH; Wijdeven RHM; Lenselink EB; Neefjes J; van Boeckel CAA; van Westen GJP; van der Stelt M
J Chem Inf Model; 2019 Mar; 59(3):1221-1229. PubMed ID: 30372617
[TBL] [Abstract][Full Text] [Related]
15. The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer.
Essegian D; Khurana R; Stathias V; Schürer SC
Cell Rep Med; 2020 Oct; 1(7):100128. PubMed ID: 33205077
[TBL] [Abstract][Full Text] [Related]
16. Systematic Profiling and Evaluation of Structure-based Kinase-Inhibitor Interactome in Cervical Cancer by Integrating In Silico Analyses and In Vitro Assays at Molecular and Cellular Levels.
Zhu LX; Liu Q; Hua YF; Yang N; Zhang XG; Ding X
Comput Biol Chem; 2019 Jun; 80():324-332. PubMed ID: 31078911
[TBL] [Abstract][Full Text] [Related]
17. Pocketome of human kinases: prioritizing the ATP binding sites of (yet) untapped protein kinases for drug discovery.
Volkamer A; Eid S; Turk S; Jaeger S; Rippmann F; Fulle S
J Chem Inf Model; 2015 Mar; 55(3):538-49. PubMed ID: 25557645
[TBL] [Abstract][Full Text] [Related]
18. Leveraging Structural Diversity and Allosteric Regulatory Mechanisms of Protein Kinases in the Discovery of Small Molecule Inhibitors.
Verkhivker GM
Curr Med Chem; 2017; 24(42):4838-4872. PubMed ID: 27719654
[TBL] [Abstract][Full Text] [Related]
19. Extending kinome coverage by analysis of kinase inhibitor broad profiling data.
Jacoby E; Tresadern G; Bembenek S; Wroblowski B; Buyck C; Neefs JM; Rassokhin D; Poncelet A; Hunt J; van Vlijmen H
Drug Discov Today; 2015 Jun; 20(6):652-8. PubMed ID: 25596550
[TBL] [Abstract][Full Text] [Related]
20. Crowdsourced mapping of unexplored target space of kinase inhibitors.
Cichońska A; Ravikumar B; Allaway RJ; Wan F; Park S; Isayev O; Li S; Mason M; Lamb A; Tanoli Z; Jeon M; Kim S; Popova M; Capuzzi S; Zeng J; Dang K; Koytiger G; Kang J; Wells CI; Willson TM; ; Oprea TI; Schlessinger A; Drewry DH; Stolovitzky G; Wennerberg K; Guinney J; Aittokallio T
Nat Commun; 2021 Jun; 12(1):3307. PubMed ID: 34083538
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
