BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

398 related articles for article (PubMed ID: 31543463)

  • 1. Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.
    Guièze R; Liu VM; Rosebrock D; Jourdain AA; Hernández-Sánchez M; Martinez Zurita A; Sun J; Ten Hacken E; Baranowski K; Thompson PA; Heo JM; Cartun Z; Aygün O; Iorgulescu JB; Zhang W; Notarangelo G; Livitz D; Li S; Davids MS; Biran A; Fernandes SM; Brown JR; Lako A; Ciantra ZB; Lawlor MA; Keskin DB; Udeshi ND; Wierda WG; Livak KJ; Letai AG; Neuberg D; Harper JW; Carr SA; Piccioni F; Ott CJ; Leshchiner I; Johannessen CM; Doench J; Mootha VK; Getz G; Wu CJ
    Cancer Cell; 2019 Oct; 36(4):369-384.e13. PubMed ID: 31543463
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies.
    Chong SJF; Zhu F; Dashevsky O; Mizuno R; Lai JX; Hackett L; Ryan CE; Collins MC; Iorgulescu JB; Guièze R; Penailillo J; Carrasco R; Hwang YC; Muñoz DP; Bouhaddou M; Lim YC; Wu CJ; Allan JN; Furman RR; Goh BC; Pervaiz S; Coppé JP; Mitsiades CS; Davids MS
    J Clin Invest; 2023 Nov; 133(22):. PubMed ID: 37751299
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
    Liu J; Li S; Wang Q; Feng Y; Xing H; Yang X; Guo Y; Guo Y; Sun H; Liu X; Yang S; Mei Z; Zhu Y; Cheng Z; Chen S; Xu M; Zhang W; Wan N; Wang J; Ma Y; Zhang S; Luan X; Xu A; Li L; Wang H; Yang X; Hong Y; Xue H; Yuan X; Hu N; Song X; Wang Z; Liu X; Wang L; Liu Y
    Blood; 2024 May; 143(18):1825-1836. PubMed ID: 38211332
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer.
    Valko Z; Megyesfalvi Z; Schwendenwein A; Lang C; Paku S; Barany N; Ferencz B; Horvath-Rozsas A; Kovacs I; Schlegl E; Pozonec V; Boettiger K; Rezeli M; Marko-Varga G; Renyi-Vamos F; Hoda MA; Klikovits T; Hoetzenecker K; Grusch M; Laszlo V; Dome B; Schelch K
    Br J Cancer; 2023 May; 128(10):1850-1861. PubMed ID: 36918717
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells
    Fatima N; Shen Y; Crassini K; Burling O; Thurgood L; Iwanowicz EJ; Lang H; Karanewsky DS; Christopherson RI; Mulligan SP; Best OG
    Leuk Lymphoma; 2024 May; 65(5):585-597. PubMed ID: 38227293
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Venetoclax resistance in acute myeloid leukaemia-Clinical and biological insights.
    Nachmias B; Aumann S; Haran A; Schimmer AD
    Br J Haematol; 2024 Apr; 204(4):1146-1158. PubMed ID: 38296617
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples.
    Khalsa JK; Cha J; Utro F; Naeem A; Murali I; Kuang Y; Vasquez K; Li L; Tyekucheva S; Fernandes SM; Veronese L; Guieze R; Sasi BK; Wang Z; Machado JH; Bai H; Alasfour M; Rhrissorrakrai K; Levovitz C; Danysh BP; Slowik K; Jacobs RA; Davids MS; Paweletz CP; Leshchiner I; Parida L; Getz G; Brown JR
    Blood; 2023 Aug; 142(5):421-433. PubMed ID: 37146250
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
    Zhang Q; Riley-Gillis B; Han L; Jia Y; Lodi A; Zhang H; Ganesan S; Pan R; Konoplev SN; Sweeney SR; Ryan JA; Jitkova Y; Dunner K; Grosskurth SE; Vijay P; Ghosh S; Lu C; Ma W; Kurtz S; Ruvolo VR; Ma H; Weng CC; Ramage CL; Baran N; Shi C; Cai T; Davis RE; Battula VL; Mi Y; Wang J; DiNardo CD; Andreeff M; Tyner JW; Schimmer A; Letai A; Padua RA; Bueso-Ramos CE; Tiziani S; Leverson J; Popovic R; Konopleva M
    Signal Transduct Target Ther; 2022 Feb; 7(1):51. PubMed ID: 35185150
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Enhancing venetoclax activity in hematological malignancies.
    Satta T; Grant S
    Expert Opin Investig Drugs; 2020 Jul; 29(7):697-708. PubMed ID: 32600066
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rational combination strategies to enhance venetoclax activity and overcome resistance in hematologic malignancies.
    Grant S
    Leuk Lymphoma; 2018 Jun; 59(6):1292-1299. PubMed ID: 28838268
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The application of BH3 mimetics in myeloid leukemias.
    Parry N; Wheadon H; Copland M
    Cell Death Dis; 2021 Feb; 12(2):222. PubMed ID: 33637708
    [TBL] [Abstract][Full Text] [Related]  

  • 12. T cells with high BCL-2 expression induced by venetoclax impact anti-leukemic immunity "graft-versus-leukemia effects".
    Nagasaki J; Nishimoto M; Koh H; Okamura H; Nakamae M; Sakatoku K; Ido K; Kuno M; Makuuchi Y; Takakuwa T; Nakashima Y; Hino M; Nakamae H
    Blood Cancer J; 2024 May; 14(1):79. PubMed ID: 38744860
    [No Abstract]   [Full Text] [Related]  

  • 13. Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment?
    Leverson JD; Cojocari D
    Front Oncol; 2018; 8():458. PubMed ID: 30406027
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Lee JB, Khan DH, Hurren R, et al. Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production. Blood. 2021;138(3):234-245.
    Blood; 2023 Mar; 141(12):1495. PubMed ID: 36951880
    [No Abstract]   [Full Text] [Related]  

  • 15. Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.
    Sharon D; Cathelin S; Mirali S; Di Trani JM; Yanofsky DJ; Keon KA; Rubinstein JL; Schimmer AD; Ketela T; Chan SM
    Sci Transl Med; 2019 Oct; 11(516):. PubMed ID: 31666400
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
    Bhatt S; Pioso MS; Olesinski EA; Yilma B; Ryan JA; Mashaka T; Leutz B; Adamia S; Zhu H; Kuang Y; Mogili A; Louissaint A; Bohl SR; Kim AS; Mehta AK; Sanghavi S; Wang Y; Morris E; Halilovic E; Paweletz CP; Weinstock DM; Garcia JS; Letai A
    Cancer Cell; 2020 Dec; 38(6):872-890.e6. PubMed ID: 33217342
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance.
    Kapoor I; Bodo J; Hill BT; Hsi ED; Almasan A
    Cell Death Dis; 2020 Nov; 11(11):941. PubMed ID: 33139702
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.
    Pei S; Pollyea DA; Gustafson A; Stevens BM; Minhajuddin M; Fu R; Riemondy KA; Gillen AE; Sheridan RM; Kim J; Costello JC; Amaya ML; Inguva A; Winters A; Ye H; Krug A; Jones CL; Adane B; Khan N; Ponder J; Schowinsky J; Abbott D; Hammes A; Myers JR; Ashton JM; Nemkov T; D'Alessandro A; Gutman JA; Ramsey HE; Savona MR; Smith CA; Jordan CT
    Cancer Discov; 2020 Apr; 10(4):536-551. PubMed ID: 31974170
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.
    Jones CL; Stevens BM; Pollyea DA; Culp-Hill R; Reisz JA; Nemkov T; Gehrke S; Gamboni F; Krug A; Winters A; Pei S; Gustafson A; Ye H; Inguva A; Amaya M; Minhajuddin M; Abbott D; Becker MW; DeGregori J; Smith CA; D'Alessandro A; Jordan CT
    Cell Stem Cell; 2020 Nov; 27(5):748-764.e4. PubMed ID: 32822582
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML.
    DiNardo CD; Tiong IS; Quaglieri A; MacRaild S; Loghavi S; Brown FC; Thijssen R; Pomilio G; Ivey A; Salmon JM; Glytsou C; Fleming SA; Zhang Q; Ma H; Patel KP; Kornblau SM; Xu Z; Chua CC; Chen X; Blombery P; Flensburg C; Cummings N; Aifantis I; Kantarjian H; Huang DCS; Roberts AW; Majewski IJ; Konopleva M; Wei AH
    Blood; 2020 Mar; 135(11):791-803. PubMed ID: 31932844
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.