354 related articles for article (PubMed ID: 31548371)
1. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Imberdis T; Negri J; Ramalingam N; Terry-Kantor E; Ho GPH; Fanning S; Stirtz G; Kim TE; Levy OA; Young-Pearse TL; Selkoe D; Dettmer U
Proc Natl Acad Sci U S A; 2019 Oct; 116(41):20760-20769. PubMed ID: 31548371
[TBL] [Abstract][Full Text] [Related]
2. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.
Terry-Kantor E; Tripathi A; Imberdis T; LaVoie ZM; Ho GPH; Selkoe D; Fanning S; Ramalingam N; Dettmer U
Int J Mol Sci; 2020 Jul; 21(15):. PubMed ID: 32707907
[TBL] [Abstract][Full Text] [Related]
3. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
Tripathi A; Alnakhala H; Terry-Kantor E; Newman A; Liu L; Imberdis T; Fanning S; Nuber S; Ramalingam N; Selkoe D; Dettmer U
J Neurosci; 2022 Mar; 42(10):2116-2130. PubMed ID: 35086904
[TBL] [Abstract][Full Text] [Related]
4. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Nuber S; Nam AY; Rajsombath MM; Cirka H; Hronowski X; Wang J; Hodgetts K; Kalinichenko LS; Müller CP; Lambrecht V; Winkler J; Weihofen A; Imberdis T; Dettmer U; Fanning S; Selkoe DJ
Ann Neurol; 2021 Jan; 89(1):74-90. PubMed ID: 32996158
[TBL] [Abstract][Full Text] [Related]
5. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Fanning S; Haque A; Imberdis T; Baru V; Barrasa MI; Nuber S; Termine D; Ramalingam N; Ho GPH; Noble T; Sandoe J; Lou Y; Landgraf D; Freyzon Y; Newby G; Soldner F; Terry-Kantor E; Kim TE; Hofbauer HF; Becuwe M; Jaenisch R; Pincus D; Clish CB; Walther TC; Farese RV; Srinivasan S; Welte MA; Kohlwein SD; Dettmer U; Lindquist S; Selkoe D
Mol Cell; 2019 Mar; 73(5):1001-1014.e8. PubMed ID: 30527540
[TBL] [Abstract][Full Text] [Related]
6. Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Dettmer U; Ramalingam N; von Saucken VE; Kim TE; Newman AJ; Terry-Kantor E; Nuber S; Ericsson M; Fanning S; Bartels T; Lindquist S; Levy OA; Selkoe D
Hum Mol Genet; 2017 Sep; 26(18):3466-3481. PubMed ID: 28911198
[TBL] [Abstract][Full Text] [Related]
7. KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.
Dettmer U; Newman AJ; von Saucken VE; Bartels T; Selkoe D
Proc Natl Acad Sci U S A; 2015 Aug; 112(31):9596-601. PubMed ID: 26153422
[TBL] [Abstract][Full Text] [Related]
8. Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction.
Ericsson M; von Saucken V; Newman AJ; Doehr L; Hoesch C; Kim TE; Dettmer U
Brain Res; 2021 May; 1758():147349. PubMed ID: 33571519
[TBL] [Abstract][Full Text] [Related]
9. Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice.
Rajsombath MM; Nam AY; Ericsson M; Nuber S
J Neurosci; 2019 Sep; 39(38):7628-7640. PubMed ID: 31405930
[TBL] [Abstract][Full Text] [Related]
10. Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.
Nuber S; Rajsombath M; Minakaki G; Winkler J; Müller CP; Ericsson M; Caldarone B; Dettmer U; Selkoe DJ
Neuron; 2018 Oct; 100(1):75-90.e5. PubMed ID: 30308173
[TBL] [Abstract][Full Text] [Related]
11. Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity.
Kim TE; Newman AJ; Imberdis T; Brontesi L; Tripathi A; Ramalingam N; Fanning S; Selkoe D; Dettmer U
Hum Mol Genet; 2021 Nov; 30(23):2332-2346. PubMed ID: 34254125
[TBL] [Abstract][Full Text] [Related]
12. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
Glajch KE; Moors TE; Chen Y; Bechade PA; Nam AY; Rajsombath MM; McCaffery TD; Dettmer U; Weihofen A; Hirst WD; Selkoe DJ; Nuber S
Proc Natl Acad Sci U S A; 2021 Aug; 118(31):. PubMed ID: 34326260
[TBL] [Abstract][Full Text] [Related]
13. MUFA synthesis and stearoyl-CoA desaturase as a new pharmacological target for modulation of lipid and alpha-synuclein interaction against Parkinson's disease synucleinopathy.
Kula J; Kuter KZ
Neuropharmacology; 2024 May; 249():109865. PubMed ID: 38342377
[TBL] [Abstract][Full Text] [Related]
14. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.
Nuber S; Chung CY; Tardiff DF; Bechade PA; McCaffery TD; Shimanaka K; Choi J; Chang B; Raja W; Neves E; Burke C; Jiang X; Xu P; Khurana V; Dettmer U; Fanning S; Rhodes KJ; Selkoe DJ; Scannevin RH
Neurotherapeutics; 2022 Apr; 19(3):1018-1036. PubMed ID: 35445353
[TBL] [Abstract][Full Text] [Related]
15. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.
Dettmer U; Newman AJ; Soldner F; Luth ES; Kim NC; von Saucken VE; Sanderson JB; Jaenisch R; Bartels T; Selkoe D
Nat Commun; 2015 Jun; 6():7314. PubMed ID: 26076669
[TBL] [Abstract][Full Text] [Related]
16. SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.
Nicholatos JW; Groot J; Dhokai S; Tran D; Hrdlicka L; Carlile TM; Bennion M; Dalkilic-Liddle I; Hirst WD; Weihofen A
eNeuro; 2021; 8(4):. PubMed ID: 34301719
[TBL] [Abstract][Full Text] [Related]
17. Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.
Rutherford NJ; Dhillon JS; Riffe CJ; Howard JK; Brooks M; Giasson BI
Hum Mol Genet; 2017 Dec; 26(24):4906-4915. PubMed ID: 29036344
[TBL] [Abstract][Full Text] [Related]
18. Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions.
Tanriöver G; Bacioglu M; Schweighauser M; Mahler J; Wegenast-Braun BM; Skodras A; Obermüller U; Barth M; Kronenberg-Versteeg D; Nilsson KPR; Shimshek DR; Kahle PJ; Eisele YS; Jucker M
Acta Neuropathol Commun; 2020 Aug; 8(1):133. PubMed ID: 32787922
[TBL] [Abstract][Full Text] [Related]
19. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.
Vincent BM; Tardiff DF; Piotrowski JS; Aron R; Lucas MC; Chung CY; Bacherman H; Chen Y; Pires M; Subramaniam R; Doshi DB; Sadlish H; Raja WK; Solís EJ; Khurana V; Le Bourdonnec B; Scannevin RH; Rhodes KJ
Cell Rep; 2018 Dec; 25(10):2742-2754.e31. PubMed ID: 30517862
[TBL] [Abstract][Full Text] [Related]
20. Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.
Nuber S; Zhang X; McCaffery TD; Moors TE; Adom MA; Hahn WN; Martin D; Ericsson M; Tripathi A; Dettmer U; Svenningsson P; Selkoe DJ
NPJ Parkinsons Dis; 2024 Feb; 10(1):47. PubMed ID: 38424059
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]