BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 31550663)

  • 1. A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine.
    Catalano R; Rocca R; Juli G; Costa G; Maruca A; Artese A; Caracciolo D; Tagliaferri P; Alcaro S; Tassone P; Amodio N
    Eur J Med Chem; 2019 Dec; 183():111715. PubMed ID: 31550663
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
    Qi W; Zhao K; Gu J; Huang Y; Wang Y; Zhang H; Zhang M; Zhang J; Yu Z; Li L; Teng L; Chuai S; Zhang C; Zhao M; Chan H; Chen Z; Fang D; Fei Q; Feng L; Feng L; Gao Y; Ge H; Ge X; Li G; Lingel A; Lin Y; Liu Y; Luo F; Shi M; Wang L; Wang Z; Yu Y; Zeng J; Zeng C; Zhang L; Zhang Q; Zhou S; Oyang C; Atadja P; Li E
    Nat Chem Biol; 2017 Apr; 13(4):381-388. PubMed ID: 28135235
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.
    Kong X; Chen L; Jiao L; Jiang X; Lian F; Lu J; Zhu K; Du D; Liu J; Ding H; Zhang N; Shen J; Zheng M; Chen K; Liu X; Jiang H; Luo C
    J Med Chem; 2014 Nov; 57(22):9512-21. PubMed ID: 25369470
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
    He Y; Selvaraju S; Curtin ML; Jakob CG; Zhu H; Comess KM; Shaw B; The J; Lima-Fernandes E; Szewczyk MM; Cheng D; Klinge KL; Li HQ; Pliushchev M; Algire MA; Maag D; Guo J; Dietrich J; Panchal SC; Petros AM; Sweis RF; Torrent M; Bigelow LJ; Senisterra G; Li F; Kennedy S; Wu Q; Osterling DJ; Lindley DJ; Gao W; Galasinski S; Barsyte-Lovejoy D; Vedadi M; Buchanan FG; Arrowsmith CH; Chiang GG; Sun C; Pappano WN
    Nat Chem Biol; 2017 Apr; 13(4):389-395. PubMed ID: 28135237
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Allosteric Inactivation of Polycomb Repressive Complex 2 (PRC2) by Inhibiting Its Adapter Protein: Embryonic Ectodomain Development (EED).
    Yang CY; Wang S
    J Med Chem; 2017 Mar; 60(6):2212-2214. PubMed ID: 28256832
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
    Lingel A; Sendzik M; Huang Y; Shultz MD; Cantwell J; Dillon MP; Fu X; Fuller J; Gabriel T; Gu J; Jiang X; Li L; Liang F; McKenna M; Qi W; Rao W; Sheng X; Shu W; Sutton J; Taft B; Wang L; Zeng J; Zhang H; Zhang M; Zhao K; Lindvall M; Bussiere DE
    J Med Chem; 2017 Jan; 60(1):415-427. PubMed ID: 27992714
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations.
    Zhu K; Du D; Yang R; Tao H; Zhang H
    Chem Pharm Bull (Tokyo); 2020 Jan; 68(1):58-63. PubMed ID: 31685780
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.
    Li L; Zhang H; Zhang M; Zhao M; Feng L; Luo X; Gao Z; Huang Y; Ardayfio O; Zhang JH; Lin Y; Fan H; Mi Y; Li G; Liu L; Feng L; Luo F; Teng L; Qi W; Ottl J; Lingel A; Bussiere DE; Yu Z; Atadja P; Lu C; Li E; Gu J; Zhao K
    PLoS One; 2017; 12(1):e0169855. PubMed ID: 28072869
    [TBL] [Abstract][Full Text] [Related]  

  • 9. EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes.
    Hernando H; Gelato KA; Lesche R; Beckmann G; Koehr S; Otto S; Steigemann P; Stresemann C
    Mol Cancer Ther; 2016 Feb; 15(2):287-98. PubMed ID: 26590165
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
    Huang Y; Zhang J; Yu Z; Zhang H; Wang Y; Lingel A; Qi W; Gu J; Zhao K; Shultz MD; Wang L; Fu X; Sun Y; Zhang Q; Jiang X; Zhang J; Zhang C; Li L; Zeng J; Feng L; Zhang C; Liu Y; Zhang M; Zhang L; Zhao M; Gao Z; Liu X; Fang D; Guo H; Mi Y; Gabriel T; Dillon MP; Atadja P; Oyang C
    J Med Chem; 2017 Mar; 60(6):2215-2226. PubMed ID: 28092155
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment.
    Cook N; Chen J; Zhou J; Wu D
    Curr Top Med Chem; 2021; 21(31):2771-2777. PubMed ID: 34544341
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
    Bagal SK; Gregson C; O' Donovan DH; Pike KG; Bloecher A; Barton P; Borodovsky A; Code E; Fillery SM; Hsu JH; Kawatkar SP; Li C; Longmire D; Nai Y; Nash SC; Pike A; Robinson J; Read JA; Rawlins PB; Shen M; Tang J; Wang P; Woods H; Williamson B
    J Med Chem; 2021 Dec; 64(23):17146-17183. PubMed ID: 34807608
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
    Du D; Xu D; Zhu L; Stazi G; Zwergel C; Liu Y; Luo Z; Li Y; Zhang Y; Zhu K; Ding Y; Liu J; Fan S; Zhao K; Zhang N; Kong X; Jiang H; Chen K; Zhao K; Valente S; Min J; Duan W; Luo C
    J Med Chem; 2021 Jun; 64(12):8194-8207. PubMed ID: 34077206
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
    Brooun A; Gajiwala KS; Deng YL; Liu W; Bolaños B; Bingham P; He YA; Diehl W; Grable N; Kung PP; Sutton S; Maegley KA; Yu X; Stewart AE
    Nat Commun; 2016 Apr; 7():11384. PubMed ID: 27122193
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2.
    Huang D; Tian S; Qi Y; Zhang JZH
    Chemphyschem; 2020 Feb; 21(3):263-271. PubMed ID: 31816138
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rapid Identification of Novel Allosteric PRC2 Inhibitors.
    Read JA; Tart J; Rawlins PB; Gregson C; Jones K; Gao N; Zhu X; Tomlinson R; Code E; Cheung T; Chen H; Kawatkar SP; Bloecher A; Bagal S; O'Donovan DH; Robinson J
    ACS Chem Biol; 2019 Oct; 14(10):2134-2140. PubMed ID: 31525019
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeting histone methyltransferase EZH2 as cancer treatment.
    Kondo Y
    J Biochem; 2014 Nov; 156(5):249-57. PubMed ID: 25179367
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Histone methylation by PRC2 is inhibited by active chromatin marks.
    Schmitges FW; Prusty AB; Faty M; Stützer A; Lingaraju GM; Aiwazian J; Sack R; Hess D; Li L; Zhou S; Bunker RD; Wirth U; Bouwmeester T; Bauer A; Ly-Hartig N; Zhao K; Chan H; Gu J; Gut H; Fischle W; Müller J; Thomä NH
    Mol Cell; 2011 May; 42(3):330-41. PubMed ID: 21549310
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure, mechanism, and regulation of polycomb-repressive complex 2.
    Moritz LE; Trievel RC
    J Biol Chem; 2018 Sep; 293(36):13805-13814. PubMed ID: 28912274
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene.
    Pandya P; Pasvolsky R; Babichev Y; Braiman A; Witte S; Altman A; Isakov N
    Biochem Biophys Res Commun; 2019 Feb; 509(2):469-475. PubMed ID: 30595380
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.