BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

216 related articles for article (PubMed ID: 31562320)

  • 1. Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility.
    Liu X; Zhao Y; Shi H; Zhang Y; Yin X; Liu M; Zhang H; He Y; Lu B; Jin T; Li F
    Nat Commun; 2019 Sep; 10(1):4206. PubMed ID: 31562320
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.
    Yu X; Chan HTC; Fisher H; Penfold CA; Kim J; Inzhelevskaya T; Mockridge CI; French RR; Duriez PJ; Douglas LR; English V; Verbeek JS; White AL; Tews I; Glennie MJ; Cragg MS
    Cancer Cell; 2020 Jun; 37(6):850-866.e7. PubMed ID: 32442402
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.
    Li F; Ravetch JV
    Science; 2011 Aug; 333(6045):1030-4. PubMed ID: 21852502
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.
    White AL; Chan HT; French RR; Willoughby J; Mockridge CI; Roghanian A; Penfold CA; Booth SG; Dodhy A; Polak ME; Potter EA; Ardern-Jones MR; Verbeek JS; Johnson PW; Al-Shamkhani A; Cragg MS; Beers SA; Glennie MJ
    Cancer Cell; 2015 Jan; 27(1):138-48. PubMed ID: 25500122
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fcγ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization.
    White AL; Dou L; Chan HT; Field VL; Mockridge CI; Moss K; Williams EL; Booth SG; French RR; Potter EA; Butts C; Al-Shamkhani A; Cragg MS; Verbeek JS; Johnson PW; Glennie MJ; Beers SA
    J Immunol; 2014 Aug; 193(4):1828-35. PubMed ID: 25024386
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of crosslinking for agonistic CD40 monoclonal antibodies as immune therapy of cancer.
    Richman LP; Vonderheide RH
    Cancer Immunol Res; 2014 Jan; 2(1):19-26. PubMed ID: 24416732
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody.
    Zhang D; Goldberg MV; Chiu ML
    J Biol Chem; 2016 Dec; 291(53):27134-27146. PubMed ID: 27856634
    [TBL] [Abstract][Full Text] [Related]  

  • 8. An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.
    Wilson NS; Yang B; Yang A; Loeser S; Marsters S; Lawrence D; Li Y; Pitti R; Totpal K; Yee S; Ross S; Vernes JM; Lu Y; Adams C; Offringa R; Kelley B; Hymowitz S; Daniel D; Meng G; Ashkenazi A
    Cancer Cell; 2011 Jan; 19(1):101-13. PubMed ID: 21251615
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement.
    Dahan R; Barnhart BC; Li F; Yamniuk AP; Korman AJ; Ravetch JV
    Cancer Cell; 2016 Jun; 29(6):820-831. PubMed ID: 27265505
    [TBL] [Abstract][Full Text] [Related]  

  • 10. FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs.
    White AL; Chan HT; French RR; Beers SA; Cragg MS; Johnson PW; Glennie MJ
    Cancer Immunol Immunother; 2013 May; 62(5):941-8. PubMed ID: 23543215
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity.
    Knorr DA; Dahan R; Ravetch JV
    Proc Natl Acad Sci U S A; 2018 Oct; 115(43):11048-11053. PubMed ID: 30297432
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody.
    White AL; Chan HT; Roghanian A; French RR; Mockridge CI; Tutt AL; Dixon SV; Ajona D; Verbeek JS; Al-Shamkhani A; Cragg MS; Beers SA; Glennie MJ
    J Immunol; 2011 Aug; 187(4):1754-63. PubMed ID: 21742972
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors.
    Stavenhagen JB; Gorlatov S; Tuaillon N; Rankin CT; Li H; Burke S; Huang L; Vijh S; Johnson S; Bonvini E; Koenig S
    Cancer Res; 2007 Sep; 67(18):8882-90. PubMed ID: 17875730
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants.
    Dashivets T; Thomann M; Rueger P; Knaupp A; Buchner J; Schlothauer T
    PLoS One; 2015; 10(12):e0143520. PubMed ID: 26657484
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular aspects of human FcgammaR interactions with IgG: functional and therapeutic consequences.
    Sibéril S; Dutertre CA; Boix C; Bonnin E; Ménez R; Stura E; Jorieux S; Fridman WH; Teillaud JL
    Immunol Lett; 2006 Aug; 106(2):111-8. PubMed ID: 16797726
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cell targeting and immunostimulatory properties of a novel Fcγ-receptor-independent agonistic anti-CD40 antibody in rhesus macaques.
    Yan X; Ols S; Arcoverde Cerveira R; Lenart K; Hellgren F; Ye K; Cagigi A; Buggert M; Nimmerjahn F; Falkesgaard Højen J; Parera D; Pessara U; Fischer S; Loré K
    Cell Mol Life Sci; 2023 Jun; 80(7):189. PubMed ID: 37353664
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies.
    Horton HM; Bernett MJ; Peipp M; Pong E; Karki S; Chu SY; Richards JO; Chen H; Repp R; Desjarlais JR; Zhukovsky EA
    Blood; 2010 Oct; 116(16):3004-12. PubMed ID: 20616215
    [TBL] [Abstract][Full Text] [Related]  

  • 18. IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.
    Lee CH; Romain G; Yan W; Watanabe M; Charab W; Todorova B; Lee J; Triplett K; Donkor M; Lungu OI; Lux A; Marshall N; Lindorfer MA; Goff OR; Balbino B; Kang TH; Tanno H; Delidakis G; Alford C; Taylor RP; Nimmerjahn F; Varadarajan N; Bruhns P; Zhang YJ; Georgiou G
    Nat Immunol; 2017 Aug; 18(8):889-898. PubMed ID: 28604720
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Agonistic CD40 antibodies and cancer therapy.
    Vonderheide RH; Glennie MJ
    Clin Cancer Res; 2013 Mar; 19(5):1035-43. PubMed ID: 23460534
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A Cell-Based Reporter Assay Measuring the Activation of Fc Gamma Receptors Induced by Therapeutic Monoclonal Antibodies.
    Aoyama M; Tada M; Ishii-Watabe A
    Methods Mol Biol; 2019; 1904():423-429. PubMed ID: 30539484
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.