BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

202 related articles for article (PubMed ID: 31583565)

  • 1. Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells.
    Kopa P; Macieja A; Gulbas I; Pastwa E; Poplawski T
    Mol Biol Rep; 2020 Jan; 47(1):67-76. PubMed ID: 31583565
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.
    Macieja A; Kopa P; Galita G; Pastwa E; Majsterek I; Poplawski T
    Mol Biol Rep; 2019 Aug; 46(4):3625-3636. PubMed ID: 31020489
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
    Zhao Y; Thomas HD; Batey MA; Cowell IG; Richardson CJ; Griffin RJ; Calvert AH; Newell DR; Smith GC; Curtin NJ
    Cancer Res; 2006 May; 66(10):5354-62. PubMed ID: 16707462
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DNA double-strand breaks repair inhibitors potentiates the combined effect of VP-16 and CDDP in human colorectal adenocarcinoma (LoVo) cells.
    Kopa P; Macieja A; Pastwa E; Majsterek I; Poplawski T
    Mol Biol Rep; 2021 Jan; 48(1):709-720. PubMed ID: 33389482
    [TBL] [Abstract][Full Text] [Related]  

  • 5. NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.
    Toyoda E; Kagaya S; Cowell IG; Kurosawa A; Kamoshita K; Nishikawa K; Iiizumi S; Koyama H; Austin CA; Adachi N
    J Biol Chem; 2008 Aug; 283(35):23711-20. PubMed ID: 18596031
    [TBL] [Abstract][Full Text] [Related]  

  • 6. NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II{alpha} and DNA-dependent protein kinase.
    Hisatomi T; Sueoka-Aragane N; Sato A; Tomimasu R; Ide M; Kurimasa A; Okamoto K; Kimura S; Sueoka E
    Blood; 2011 Mar; 117(13):3575-84. PubMed ID: 21245486
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells.
    Pastwa E; Poplawski T; Lewandowska U; Somiari SB; Blasiak J; Somiari RI
    Int J Biochem Cell Biol; 2014 Aug; 53():423-31. PubMed ID: 24953561
    [TBL] [Abstract][Full Text] [Related]  

  • 8. DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.
    Guo L; Liu X; Jiang Y; Nishikawa K; Plunkett W
    Mol Pharmacol; 2011 Aug; 80(2):321-7. PubMed ID: 21546556
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.
    Tavecchio M; Munck JM; Cano C; Newell DR; Curtin NJ
    Cancer Chemother Pharmacol; 2012 Jan; 69(1):155-64. PubMed ID: 21630086
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of dual DNA-PK MDR1 inhibitors for the potentiation of cytotoxic drug activity.
    Mould E; Berry P; Jamieson D; Hill C; Cano C; Tan N; Elliott S; Durkacz B; Newell D; Willmore E
    Biochem Pharmacol; 2014 Mar; 88(1):58-65. PubMed ID: 24418411
    [TBL] [Abstract][Full Text] [Related]  

  • 11. DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin.
    Ciszewski WM; Tavecchio M; Dastych J; Curtin NJ
    Breast Cancer Res Treat; 2014 Jan; 143(1):47-55. PubMed ID: 24292814
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines.
    Das CM; Aguilera D; Vasquez H; Prasad P; Zhang M; Wolff JE; Gopalakrishnan V
    J Neurooncol; 2007 Nov; 85(2):159-70. PubMed ID: 17534580
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphatidylinositol 3-kinases inhibitor LY294002 potentiates the cytotoxic effects of doxorubicin, vincristine, and etoposide in a panel of cancer cell lines.
    Badinloo M; Esmaeili-Mahani S
    Fundam Clin Pharmacol; 2014 Aug; 28(4):414-22. PubMed ID: 23837575
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide.
    Biasoli D; Kahn SA; Cornélio TA; Furtado M; Campanati L; Chneiweiss H; Moura-Neto V; Borges HL
    Cell Death Dis; 2013 Aug; 4(8):e767. PubMed ID: 23949216
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells.
    Shingu T; Yamada K; Hara N; Moritake K; Osago H; Terashima M; Uemura T; Yamasaki T; Tsuchiya M
    Cancer Res; 2003 Jul; 63(14):4044-7. PubMed ID: 12874004
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair.
    Sunada S; Kanai H; Lee Y; Yasuda T; Hirakawa H; Liu C; Fujimori A; Uesaka M; Okayasu R
    Cancer Sci; 2016 Sep; 107(9):1250-5. PubMed ID: 27341700
    [TBL] [Abstract][Full Text] [Related]  

  • 17. DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair.
    Yanai M; Makino H; Ping B; Takeda K; Tanaka N; Sakamoto T; Yamaguchi K; Kodani M; Yamasaki A; Igishi T; Shimizu E
    Yonago Acta Med; 2017 Mar; 60(1):9-15. PubMed ID: 28331416
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials.
    Guo L; Liu X; Nishikawa K; Plunkett W
    Mol Cancer Ther; 2007 May; 6(5):1501-8. PubMed ID: 17513599
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Impact of histone deacetylase inhibitor valproic acid on the anticancer effect of etoposide on neuroblastoma cells.
    Groh T; Hrabeta J; Poljakova J; Eckschlager T; Stiborova M
    Neuro Endocrinol Lett; 2012; 33 Suppl 3():16-24. PubMed ID: 23353839
    [TBL] [Abstract][Full Text] [Related]  

  • 20. NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors.
    Onda T; Toyoda E; Miyazaki O; Seno C; Kagaya S; Okamoto K; Nishikawa K
    Cancer Lett; 2008 Jan; 259(1):99-110. PubMed ID: 17998154
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.