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2. A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia. Arriazu E; Vicente C; Pippa R; Peris I; Martínez-Balsalobre E; García-Ramírez P; Marcotegui N; Igea A; Alignani D; Rifón J; Mateos MC; Cayuela ML; Nebreda AR; Odero MD Blood Cancer J; 2020 Jan; 10(1):3. PubMed ID: 31913266 [TBL] [Abstract][Full Text] [Related]
3. PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Cristóbal I; Garcia-Orti L; Cirauqui C; Alonso MM; Calasanz MJ; Odero MD Leukemia; 2011 Apr; 25(4):606-14. PubMed ID: 21233840 [TBL] [Abstract][Full Text] [Related]
4. FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels. Chen L; Luo LF; Lu J; Li L; Liu YF; Wang J; Liu H; Song H; Jiang H; Chen SJ; Luo C; Li KK PLoS One; 2014; 9(7):e103033. PubMed ID: 25050888 [TBL] [Abstract][Full Text] [Related]
5. Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors. Smith AM; Dun MD; Lee EM; Harrison C; Kahl R; Flanagan H; Panicker N; Mashkani B; Don AS; Morris J; Toop H; Lock RB; Powell JA; Thomas D; Guthridge MA; Moore A; Ashman LK; Skelding KA; Enjeti A; Verrills NM Oncotarget; 2016 Jul; 7(30):47465-47478. PubMed ID: 27329844 [TBL] [Abstract][Full Text] [Related]
7. [Influence of PP2A activator on proliferation of HL-60 cells and analysis of PP2A activity changes in patients with acute myeloid leukemia]. Yang Y; Li XQ; Huang Q; Huang SA Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2011 Jun; 19(3):594-7. PubMed ID: 21729530 [TBL] [Abstract][Full Text] [Related]
8. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. Saddoughi SA; Gencer S; Peterson YK; Ward KE; Mukhopadhyay A; Oaks J; Bielawski J; Szulc ZM; Thomas RJ; Selvam SP; Senkal CE; Garrett-Mayer E; De Palma RM; Fedarovich D; Liu A; Habib AA; Stahelin RV; Perrotti D; Ogretmen B EMBO Mol Med; 2013 Jan; 5(1):105-21. PubMed ID: 23180565 [TBL] [Abstract][Full Text] [Related]
9. Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation. Yang Y; Huang Q; Lu Y; Li X; Huang S J Cell Biochem; 2012 Apr; 113(4):1314-22. PubMed ID: 22109829 [TBL] [Abstract][Full Text] [Related]
10. PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. Cristóbal I; Manso R; Rincón R; Caramés C; Senin C; Borrero A; Martínez-Useros J; Rodriguez M; Zazo S; Aguilera O; Madoz-Gúrpide J; Rojo F; García-Foncillas J Mol Cancer Ther; 2014 Apr; 13(4):938-47. PubMed ID: 24448818 [TBL] [Abstract][Full Text] [Related]
11. Lipid Nanosystems Enhance the Bioavailability and the Therapeutic Efficacy of FTY720 in Acute Myeloid Leukemia. Estella-Hermoso de Mendoza A; Castello-Cros R; Imbuluzqueta E; Cirauqui C; Pippa R; Odero MD; Blanco-Prieto MJ J Biomed Nanotechnol; 2015 Apr; 11(4):691-701. PubMed ID: 26310075 [TBL] [Abstract][Full Text] [Related]
12. Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma. Goto RN; Sobral LM; Stringhetta-Padovani K; Garcia CB; da Silva G; Vitek MP; Leopoldino AM Eur J Pharmacol; 2020 Sep; 882():173268. PubMed ID: 32569675 [TBL] [Abstract][Full Text] [Related]
13. Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer. Liu H; Gu Y; Wang H; Yin J; Zheng G; Zhang Z; Lu M; Wang C; He Z Oncotarget; 2015 Jun; 6(17):14913-25. PubMed ID: 25945834 [TBL] [Abstract][Full Text] [Related]
14. FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model. Szymiczek A; Pastorino S; Larson D; Tanji M; Pellegrini L; Xue J; Li S; Giorgi C; Pinton P; Takinishi Y; Pass HI; Furuya H; Gaudino G; Napolitano A; Carbone M; Yang H J Transl Med; 2017 Mar; 15(1):58. PubMed ID: 28298211 [TBL] [Abstract][Full Text] [Related]
15. PP2A activation alone and in combination with cisplatin decreases cell growth and tumor formation in human HuH6 hepatoblastoma cells. Stafman LL; Williams AP; Marayati R; Aye JM; Stewart JE; Mroczek-Musulman E; Beierle EA PLoS One; 2019; 14(4):e0214469. PubMed ID: 30969990 [TBL] [Abstract][Full Text] [Related]
16. Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity. Pippa R; Dominguez A; Christensen DJ; Moreno-Miralles I; Blanco-Prieto MJ; Vitek MP; Odero MD Leukemia; 2014 Sep; 28(9):1915-8. PubMed ID: 24781014 [No Abstract] [Full Text] [Related]
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