BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

256 related articles for article (PubMed ID: 31611389)

  • 1. KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
    Rabara D; Tran TH; Dharmaiah S; Stephens RM; McCormick F; Simanshu DK; Holderfield M
    Proc Natl Acad Sci U S A; 2019 Oct; 116(44):22122-22131. PubMed ID: 31611389
    [No Abstract]   [Full Text] [Related]  

  • 2. Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors.
    McFall T; Schomburg NK; Rossman KL; Stites EC
    Cell Commun Signal; 2020 Nov; 18(1):179. PubMed ID: 33153459
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
    Yan W; Markegard E; Dharmaiah S; Urisman A; Drew M; Esposito D; Scheffzek K; Nissley DV; McCormick F; Simanshu DK
    Cell Rep; 2020 Jul; 32(3):107909. PubMed ID: 32697994
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A systems mechanism for KRAS mutant allele-specific responses to targeted therapy.
    McFall T; Diedrich JK; Mengistu M; Littlechild SL; Paskvan KV; Sisk-Hackworth L; Moresco JJ; Shaw AS; Stites EC
    Sci Signal; 2019 Sep; 12(600):. PubMed ID: 31551296
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inactivation of
    Georgiou A; Stewart A; Cunningham D; Banerji U; Whittaker SR
    Mol Cancer Res; 2020 Jun; 18(6):835-846. PubMed ID: 32098826
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
    Johnson CW; Lin YJ; Reid D; Parker J; Pavlopoulos S; Dischinger P; Graveel C; Aguirre AJ; Steensma M; Haigis KM; Mattos C
    Cell Rep; 2019 Aug; 28(6):1538-1550.e7. PubMed ID: 31390567
    [TBL] [Abstract][Full Text] [Related]  

  • 7. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers.
    Nichols RJ; Haderk F; Stahlhut C; Schulze CJ; Hemmati G; Wildes D; Tzitzilonis C; Mordec K; Marquez A; Romero J; Hsieh T; Zaman A; Olivas V; McCoach C; Blakely CM; Wang Z; Kiss G; Koltun ES; Gill AL; Singh M; Goldsmith MA; Smith JAM; Bivona TG
    Nat Cell Biol; 2018 Sep; 20(9):1064-1073. PubMed ID: 30104724
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours.
    Rowland A; Dias MM; Wiese MD; Kichenadasse G; McKinnon RA; Karapetis CS; Sorich MJ
    Eur J Cancer; 2016 Mar; 55():122-30. PubMed ID: 26812186
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild type, or G13D mutated tumours.
    Segelov E; Waring P; Desai J; Wilson K; Gebski V; Thavaneswaran S; Elez E; Underhill C; Pavlakis N; Chantrill L; Nott L; Jefford M; Khasraw M; Day F; Wasan H; Ciardiello F; Karapetis C; Joubert W; van Hazel G; Haydon A; Price T; Tejpar S; Tebbutt N; Shapiro J
    BMC Cancer; 2016 May; 16():339. PubMed ID: 27246726
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A conserved region of c-Ha-Ras is required for efficient GTPase stimulation by GTPase activating protein but not neurofibromin.
    Yoder-Hill J; Golubic M; Stacey DW
    J Biol Chem; 1995 Nov; 270(46):27615-21. PubMed ID: 7499225
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Computational analysis of KRAS mutations: implications for different effects on the KRAS p.G12D and p.G13D mutations.
    Chen CC; Er TK; Liu YY; Hwang JK; Barrio MJ; Rodrigo M; Garcia-Toro E; Herreros-Villanueva M
    PLoS One; 2013; 8(2):e55793. PubMed ID: 23437064
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
    Lu S; Jang H; Nussinov R; Zhang J
    Sci Rep; 2016 Feb; 6():21949. PubMed ID: 26902995
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A mechanism for the response of KRAS
    McFall T; Stites EC
    Mol Cell Oncol; 2020; 7(2):1701914. PubMed ID: 32158916
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines.
    Vitiello PP; Cardone C; Martini G; Ciardiello D; Belli V; Matrone N; Barra G; Napolitano S; Della Corte C; Turano M; Furia M; Troiani T; Morgillo F; De Vita F; Ciardiello F; Martinelli E
    J Exp Clin Cancer Res; 2019 Jan; 38(1):41. PubMed ID: 30691487
    [TBL] [Abstract][Full Text] [Related]  

  • 15. KRAS mutant allele-specific imbalance (MASI) assessment in routine samples of patients with metastatic colorectal cancer.
    Malapelle U; Sgariglia R; De Stefano A; Bellevicine C; Vigliar E; de Biase D; Sepe R; Pallante P; Carlomagno C; Tallini G; Troncone G
    J Clin Pathol; 2015 Apr; 68(4):265-9. PubMed ID: 25609577
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer.
    Sherekar M; Han SW; Ghirlando R; Messing S; Drew M; Rabara D; Waybright T; Juneja P; O'Neill H; Stanley CB; Bhowmik D; Ramanathan A; Subramaniam S; Nissley DV; Gillette W; McCormick F; Esposito D
    J Biol Chem; 2020 Jan; 295(4):1105-1119. PubMed ID: 31836666
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Association KRAS G13D tumor mutated outcome in patients with chemotherapy refractory metastatic colorectal cancer treated with cetuximab.
    Tural D; Selcukbiricik F; Erdamar S; Ozkurt CU; Yanmaz T; Mandel NM; Serdengeçti S
    Hepatogastroenterology; 2013; 60(125):1035-40. PubMed ID: 23537520
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The GAP-related domain of neurofibromin attenuates proliferation and downregulates N- and K-Ras activation in Nf1-negative AML cells.
    Morgan KJ; Rowley MA; Wiesner SM; Hasz DE; Van Ness B; Largaespada DA
    Leuk Res; 2007 Aug; 31(8):1107-13. PubMed ID: 17222906
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.
    Su W; Mukherjee R; Yaeger R; Son J; Xu J; Na N; Merna Timaul N; Hechtman J; Paroder V; Lin M; Mattar M; Qiu J; Chang Q; Zhao H; Zhang J; Little M; Adachi Y; Han SW; Taylor BS; Ebi H; Abdel-Wahab O; de Stanchina E; Rudin CM; Jänne PA; McCormick F; Yao Z; Rosen N
    Mol Cell; 2022 Jul; 82(13):2443-2457.e7. PubMed ID: 35613620
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.
    Neumann J; Zeindl-Eberhart E; Kirchner T; Jung A
    Pathol Res Pract; 2009; 205(12):858-62. PubMed ID: 19679400
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.