BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 31612581)

  • 1. Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non-Histone Substrates.
    Weirich S; Schuhmacher MK; Kudithipudi S; Lungu C; Ferguson AD; Jeltsch A
    Chembiochem; 2020 Jan; 21(1-2):256-264. PubMed ID: 31612581
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation.
    Jiang Y; Trescott L; Holcomb J; Zhang X; Brunzelle J; Sirinupong N; Shi X; Yang Z
    J Mol Biol; 2014 Oct; 426(20):3413-25. PubMed ID: 24594358
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics.
    Olsen JB; Cao XJ; Han B; Chen LH; Horvath A; Richardson TI; Campbell RM; Garcia BA; Nguyen H
    Mol Cell Proteomics; 2016 Mar; 15(3):892-905. PubMed ID: 26750096
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins.
    Xu S; Zhong C; Zhang T; Ding J
    J Mol Cell Biol; 2011 Oct; 3(5):293-300. PubMed ID: 21724641
    [TBL] [Abstract][Full Text] [Related]  

  • 5. An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates.
    Ahmed H; Duan S; Arrowsmith CH; Barsyte-Lovejoy D; Schapira M
    J Proteome Res; 2016 Jun; 15(6):2052-9. PubMed ID: 27163177
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of substrates for a SET domain lysine methyltransferase predicted by multistate computational protein design.
    Lanouette S; Davey JA; Elisma F; Ning Z; Figeys D; Chica RA; Couture JF
    Structure; 2015 Jan; 23(1):206-215. PubMed ID: 25533488
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection.
    Schuhmacher MK; Rolando M; Bröhm A; Weirich S; Kudithipudi S; Buchrieser C; Jeltsch A
    J Mol Biol; 2018 Jun; 430(13):1912-1925. PubMed ID: 29733858
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Repression of p53 activity by Smyd2-mediated methylation.
    Huang J; Perez-Burgos L; Placek BJ; Sengupta R; Richter M; Dorsey JA; Kubicek S; Opravil S; Jenuwein T; Berger SL
    Nature; 2006 Nov; 444(7119):629-32. PubMed ID: 17108971
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Smyd2 conformational changes in response to p53 binding: role of the C-terminal domain.
    Chandramouli B; Melino G; Chillemi G
    Mol Oncol; 2019 Jun; 13(6):1450-1461. PubMed ID: 31069954
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.
    Wang L; Li L; Zhang H; Luo X; Dai J; Zhou S; Gu J; Zhu J; Atadja P; Lu C; Li E; Zhao K
    J Biol Chem; 2011 Nov; 286(44):38725-38737. PubMed ID: 21880715
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Histone methyltransferase SMYD2: ubiquitous regulator of disease.
    Yi X; Jiang XJ; Fang ZM
    Clin Epigenetics; 2019 Aug; 11(1):112. PubMed ID: 31370883
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Conformational Dynamics of Lysine Methyltransferase Smyd2. Insights into the Different Substrate Crevice Characteristics of Smyd2 and Smyd3.
    Chandramouli B; Chillemi G
    J Chem Inf Model; 2016 Dec; 56(12):2467-2475. PubMed ID: 27959541
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Specificity analysis of protein lysine methyltransferases using SPOT peptide arrays.
    Kudithipudi S; Kusevic D; Weirich S; Jeltsch A
    J Vis Exp; 2014 Nov; (93):e52203. PubMed ID: 25489813
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase.
    Abu-Farha M; Lambert JP; Al-Madhoun AS; Elisma F; Skerjanc IS; Figeys D
    Mol Cell Proteomics; 2008 Mar; 7(3):560-72. PubMed ID: 18065756
    [TBL] [Abstract][Full Text] [Related]  

  • 15. LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
    Nguyen H; Allali-Hassani A; Antonysamy S; Chang S; Chen LH; Curtis C; Emtage S; Fan L; Gheyi T; Li F; Liu S; Martin JR; Mendel D; Olsen JB; Pelletier L; Shatseva T; Wu S; Zhang FF; Arrowsmith CH; Brown PJ; Campbell RM; Garcia BA; Barsyte-Lovejoy D; Mader M; Vedadi M
    J Biol Chem; 2015 May; 290(22):13641-53. PubMed ID: 25825497
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2.
    Abu-Farha M; Lanouette S; Elisma F; Tremblay V; Butson J; Figeys D; Couture JF
    J Mol Cell Biol; 2011 Oct; 3(5):301-8. PubMed ID: 22028380
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling.
    Gao S; Wang Z; Wang W; Hu X; Chen P; Li J; Feng X; Wong J; Du JX
    J Biol Chem; 2017 Jul; 292(30):12702-12712. PubMed ID: 28588028
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression.
    Li LX; Zhou JX; Calvet JP; Godwin AK; Jensen RA; Li X
    Cell Death Dis; 2018 Feb; 9(3):326. PubMed ID: 29487338
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis of substrate methylation and inhibition of SMYD2.
    Ferguson AD; Larsen NA; Howard T; Pollard H; Green I; Grande C; Cheung T; Garcia-Arenas R; Cowen S; Wu J; Godin R; Chen H; Keen N
    Structure; 2011 Sep; 19(9):1262-73. PubMed ID: 21782458
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2.
    Eggert E; Hillig RC; Koehr S; Stöckigt D; Weiske J; Barak N; Mowat J; Brumby T; Christ CD; Ter Laak A; Lang T; Fernandez-Montalvan AE; Badock V; Weinmann H; Hartung IV; Barsyte-Lovejoy D; Szewczyk M; Kennedy S; Li F; Vedadi M; Brown PJ; Santhakumar V; Arrowsmith CH; Stellfeld T; Stresemann C
    J Med Chem; 2016 May; 59(10):4578-600. PubMed ID: 27075367
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.