162 related articles for article (PubMed ID: 31622602)
21. Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity.
Lemarié FL; Caron NS; Sanders SS; Schmidt ME; Nguyen YTN; Ko S; Xu X; Pouladi MA; Martin DDO; Hayden MR
Neurobiol Dis; 2021 Oct; 158():105479. PubMed ID: 34390831
[TBL] [Abstract][Full Text] [Related]
22. Mutant Huntingtin Impairs Pancreatic β-cells by Recruiting IRS-2 and Disturbing the PI3K/AKT/FoxO1 Signaling Pathway in Huntington's Disease.
Li L; Sun Y; Zhang Y; Wang W; Ye C
J Mol Neurosci; 2021 Dec; 71(12):2646-2658. PubMed ID: 34331233
[TBL] [Abstract][Full Text] [Related]
23. Spatiotemporal analysis of soluble aggregates and autophagy markers in the R6/2 mouse model.
Kumar MJV; Shah D; Giridharan M; Yadav N; Manjithaya R; Clement JP
Sci Rep; 2021 Jan; 11(1):96. PubMed ID: 33420088
[TBL] [Abstract][Full Text] [Related]
24. Pramipexole reduces soluble mutant huntingtin and protects striatal neurons through dopamine D3 receptors in a genetic model of Huntington's disease.
Luis-Ravelo D; Estévez-Silva H; Barroso-Chinea P; Afonso-Oramas D; Salas-Hernández J; Rodríguez-Núñez J; Acevedo-Arozena A; Marcellino D; González-Hernández T
Exp Neurol; 2018 Jan; 299(Pt A):137-147. PubMed ID: 29056363
[TBL] [Abstract][Full Text] [Related]
25. Bim contributes to the progression of Huntington's disease-associated phenotypes.
Roberts SL; Evans T; Yang Y; Fu Y; Button RW; Sipthorpe RJ; Cowan K; Valionyte E; Anichtchik O; Li H; Lu B; Luo S
Hum Mol Genet; 2020 Jan; 29(2):216-227. PubMed ID: 31813995
[TBL] [Abstract][Full Text] [Related]
26. Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
De Pascale M; Bissegger L; Tarantelli C; Beaufils F; Prescimone A; Mohamed Seid Hedad H; Kayali O; Orbegozo C; Raguž L; Schaefer T; Hebeisen P; Bertoni F; Wymann MP; Borsari C
Eur J Med Chem; 2023 Feb; 248():115038. PubMed ID: 36634458
[TBL] [Abstract][Full Text] [Related]
27. Trehalose rescues glial cell dysfunction in striatal cultures from HD R6/1 mice at early postnatal development.
Perucho J; Gómez A; Muñoz MP; de Yébenes JG; Mena MÁ; Casarejos MJ
Mol Cell Neurosci; 2016 Jul; 74():128-45. PubMed ID: 27236019
[TBL] [Abstract][Full Text] [Related]
28. Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT.
Fang F; Peng T; Yang S; Wang W; Zhang Y; Li H
Int J Dev Neurosci; 2016 Aug; 52():66-74. PubMed ID: 27196502
[TBL] [Abstract][Full Text] [Related]
29. Glyceraldehyde-3-Phosphate Dehydrogenase Facilitates Macroautophagic Degradation of Mutant Huntingtin Protein Aggregates.
Chaudhary S; Dhiman A; Dilawari R; Chaubey GK; Talukdar S; Modanwal R; Patidar A; Malhotra H; Raje CI; Raje M
Mol Neurobiol; 2021 Nov; 58(11):5790-5798. PubMed ID: 34406601
[TBL] [Abstract][Full Text] [Related]
30. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Ravikumar B; Vacher C; Berger Z; Davies JE; Luo S; Oroz LG; Scaravilli F; Easton DF; Duden R; O'Kane CJ; Rubinsztein DC
Nat Genet; 2004 Jun; 36(6):585-95. PubMed ID: 15146184
[TBL] [Abstract][Full Text] [Related]
31. Acute manganese treatment restores defective autophagic cargo loading in Huntington's disease cell lines.
Bryan MR; O'Brien MT; Nordham KD; Rose DIR; Foshage AM; Joshi P; Nitin R; Uhouse MA; Di Pardo A; Zhang Z; Maglione V; Aschner M; Bowman AB
Hum Mol Genet; 2019 Nov; 28(22):3825-3841. PubMed ID: 31600787
[TBL] [Abstract][Full Text] [Related]
32. Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.
Soares HP; Ming M; Mellon M; Young SH; Han L; Sinnet-Smith J; Rozengurt E
Mol Cancer Ther; 2015 Apr; 14(4):1014-23. PubMed ID: 25673820
[TBL] [Abstract][Full Text] [Related]
33. Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease.
Zhou X; Li G; Kaplan A; Gaschler MM; Zhang X; Hou Z; Jiang M; Zott R; Cremers S; Stockwell BR; Duan W
Hum Mol Genet; 2018 May; 27(9):1545-1555. PubMed ID: 29462355
[TBL] [Abstract][Full Text] [Related]
34. Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation.
Pierzynowska K; Podlacha M; Gaffke L; Rintz E; Wiśniewska K; Cyske Z; Węgrzyn G
Autophagy; 2024 May; 20(5):1159-1182. PubMed ID: 37992314
[TBL] [Abstract][Full Text] [Related]
35. Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship.
Jhanwar-Uniyal M; Wainwright JV; Mohan AL; Tobias ME; Murali R; Gandhi CD; Schmidt MH
Adv Biol Regul; 2019 May; 72():51-62. PubMed ID: 31010692
[TBL] [Abstract][Full Text] [Related]
36. Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects.
Jhanwar-Uniyal M; Amin AG; Cooper JB; Das K; Schmidt MH; Murali R
Adv Biol Regul; 2017 May; 64():39-48. PubMed ID: 28189457
[TBL] [Abstract][Full Text] [Related]
37. Preclinical efficacy of dual mTORC1/2 inhibitor AZD8055 in renal cell carcinoma harboring a TFE3 gene fusion.
Kauffman EC; Lang M; Rais-Bahrami S; Gupta GN; Wei D; Yang Y; Sourbier C; Srinivasan R
BMC Cancer; 2019 Sep; 19(1):917. PubMed ID: 31519159
[TBL] [Abstract][Full Text] [Related]
38. Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease.
Child DD; Lee JH; Pascua CJ; Chen YH; Mas Monteys A; Davidson BL
Cell Rep; 2018 Apr; 23(4):1020-1033. PubMed ID: 29694882
[TBL] [Abstract][Full Text] [Related]
39. A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration.
Lu B; Palacino J
FASEB J; 2013 May; 27(5):1820-9. PubMed ID: 23325320
[TBL] [Abstract][Full Text] [Related]
40. TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
Hegde RN; Chiki A; Petricca L; Martufi P; Arbez N; Mouchiroud L; Auwerx J; Landles C; Bates GP; Singh-Bains MK; Dragunow M; Curtis MA; Faull RL; Ross CA; Caricasole A; Lashuel HA
EMBO J; 2020 Sep; 39(17):e104671. PubMed ID: 32757223
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]