BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 31635355)

  • 1. The Fragment-Based Development of a Benzofuran Hit as a New Class of
    Duncan LF; Wang G; Ilyichova OV; Scanlon MJ; Heras B; Abbott BM
    Molecules; 2019 Oct; 24(20):. PubMed ID: 31635355
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Elaboration of a benzofuran scaffold and evaluation of binding affinity and inhibition of Escherichia coli DsbA: A fragment-based drug design approach to novel antivirulence compounds.
    Duncan LF; Wang G; Ilyichova OV; Dhouib R; Totsika M; Scanlon MJ; Heras B; Abbott BM
    Bioorg Med Chem; 2021 Sep; 45():116315. PubMed ID: 34364222
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA.
    Adams LA; Sharma P; Mohanty B; Ilyichova OV; Mulcair MD; Williams ML; Gleeson EC; Totsika M; Doak BC; Caria S; Rimmer K; Horne J; Shouldice SR; Vazirani M; Headey SJ; Plumb BR; Martin JL; Heras B; Simpson JS; Scanlon MJ
    Angew Chem Int Ed Engl; 2015 Feb; 54(7):2179-84. PubMed ID: 25556635
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence.
    Duprez W; Premkumar L; Halili MA; Lindahl F; Reid RC; Fairlie DP; Martin JL
    J Med Chem; 2015 Jan; 58(2):577-87. PubMed ID: 25470204
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials.
    Wang G; Mohanty B; Williams ML; Doak BC; Dhouib R; Totsika M; McMahon RM; Sharma G; Zheng D; Bentley MR; Ka-Yan Chin Y; Horne J; Chalmers DK; Heras B; Scanlon MJ
    ChemMedChem; 2022 Mar; 17(6):e202100673. PubMed ID: 34978144
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes.
    Kurth F; Rimmer K; Premkumar L; Mohanty B; Duprez W; Halili MA; Shouldice SR; Heras B; Fairlie DP; Scanlon MJ; Martin JL
    PLoS One; 2013; 8(11):e80210. PubMed ID: 24244651
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens.
    Totsika M; Vagenas D; Paxman JJ; Wang G; Dhouib R; Sharma P; Martin JL; Scanlon MJ; Heras B
    Antioxid Redox Signal; 2018 Sep; 29(7):653-666. PubMed ID: 29237285
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1.
    Mohanty B; Rimmer K; McMahon RM; Headey SJ; Vazirani M; Shouldice SR; Coinçon M; Tay S; Morton CJ; Simpson JS; Martin JL; Scanlon MJ
    PLoS One; 2017; 12(3):e0173436. PubMed ID: 28346540
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics.
    Verderosa AD; Dhouib R; Hong Y; Anderson TK; Heras B; Totsika M
    Sci Rep; 2021 Jan; 11(1):1569. PubMed ID: 33452354
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system.
    Halili MA; Bachu P; Lindahl F; Bechara C; Mohanty B; Reid RC; Scanlon MJ; Robinson CV; Fairlie DP; Martin JL
    ACS Chem Biol; 2015 Apr; 10(4):957-64. PubMed ID: 25603425
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors.
    McMahon RM; Premkumar L; Martin JL
    Biochim Biophys Acta; 2014 Aug; 1844(8):1391-401. PubMed ID: 24487020
    [TBL] [Abstract][Full Text] [Related]  

  • 12. NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide-dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei.
    Nebl S; Alwan WS; Williams ML; Sharma G; Taylor A; Doak BC; Wilde KL; McMahon RM; Halili MA; Martin JL; Capuano B; Fenwick RB; Mohanty B; Scanlon MJ
    J Biomol NMR; 2020 Nov; 74(10-11):595-611. PubMed ID: 32761504
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure and function of DsbA, a key bacterial oxidative folding catalyst.
    Shouldice SR; Heras B; Walden PM; Totsika M; Schembri MA; Martin JL
    Antioxid Redox Signal; 2011 May; 14(9):1729-60. PubMed ID: 21241169
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure of TcpG, the DsbA protein folding catalyst from Vibrio cholerae.
    Hu SH; Peek JA; Rattigan E; Taylor RK; Martin JL
    J Mol Biol; 1997 Apr; 268(1):137-46. PubMed ID: 9149147
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Fluoromethylketone-Fragment Conjugates Designed as Covalent Modifiers of EcDsbA are Atypical Substrates.
    Doak BC; Whitehouse RL; Rimmer K; Williams M; Heras B; Caria S; Ilyichova O; Vazirani M; Mohanty B; Harper JB; Scanlon MJ; Simpson JS
    ChemMedChem; 2024 May; ():e202300684. PubMed ID: 38742480
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising Oxidoreductase.
    Christensen S; Grøftehauge MK; Byriel K; Huston WM; Furlong E; Heras B; Martin JL; McMahon RM
    PLoS One; 2016; 11(12):e0168485. PubMed ID: 28030602
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification and characterization of novel small molecule inhibitors of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).
    Sharma R; Rani C; Mehra R; Nargotra A; Chib R; Rajput VS; Kumar S; Singh S; Sharma PR; Khan IA
    Appl Microbiol Biotechnol; 2016 Apr; 100(7):3071-85. PubMed ID: 26563552
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding.
    Guddat LW; Bardwell JC; Zander T; Martin JL
    Protein Sci; 1997 Jun; 6(6):1148-56. PubMed ID: 9194175
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure of circularly permuted DsbA(Q100T99): preserved global fold and local structural adjustments.
    Manjasetty BA; Hennecke J; Glockshuber R; Heinemann U
    Acta Crystallogr D Biol Crystallogr; 2004 Feb; 60(Pt 2):304-9. PubMed ID: 14747707
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis.
    Vivian JP; Scoullar J; Rimmer K; Bushell SR; Beddoe T; Wilce MC; Byres E; Boyle TP; Doak B; Simpson JS; Graham B; Heras B; Kahler CM; Rossjohn J; Scanlon MJ
    J Mol Biol; 2009 Dec; 394(5):931-43. PubMed ID: 19815019
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.