These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

304 related articles for article (PubMed ID: 31642962)

  • 1. Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3.
    Nihei Y; Mori K; Werner G; Arzberger T; Zhou Q; Khosravi B; Japtok J; Hermann A; Sommacal A; Weber M; ; ; Kamp F; Nuscher B; Edbauer D; Haass C
    Acta Neuropathol; 2020 Jan; 139(1):99-118. PubMed ID: 31642962
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
    Mori K; Nihei Y; Arzberger T; Zhou Q; Mackenzie IR; Hermann A; Hanisch F; ; ; Kamp F; Nuscher B; Orozco D; Edbauer D; Haass C
    EMBO Rep; 2016 Sep; 17(9):1314-25. PubMed ID: 27461252
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration.
    Ohki Y; Wenninger-Weinzierl A; Hruscha A; Asakawa K; Kawakami K; Haass C; Edbauer D; Schmid B
    Mol Neurodegener; 2017 Jan; 12(1):6. PubMed ID: 28088213
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.
    Khosravi B; Hartmann H; May S; Möhl C; Ederle H; Michaelsen M; Schludi MH; Dormann D; Edbauer D
    Hum Mol Genet; 2017 Feb; 26(4):790-800. PubMed ID: 28040728
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
    Saberi S; Stauffer JE; Jiang J; Garcia SD; Taylor AE; Schulte D; Ohkubo T; Schloffman CL; Maldonado M; Baughn M; Rodriguez MJ; Pizzo D; Cleveland D; Ravits J
    Acta Neuropathol; 2018 Mar; 135(3):459-474. PubMed ID: 29196813
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.
    Davidson YS; Flood L; Robinson AC; Nihei Y; Mori K; Rollinson S; Richardson A; Benson BC; Jones M; Snowden JS; Pickering-Brown S; Haass C; Lashley T; Mann DMA
    Acta Neuropathol Commun; 2017 Apr; 5(1):31. PubMed ID: 28431575
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.
    Cooper-Knock J; Walsh MJ; Higginbottom A; Robin Highley J; Dickman MJ; Edbauer D; Ince PG; Wharton SB; Wilson SA; Kirby J; Hautbergue GM; Shaw PJ
    Brain; 2014 Jul; 137(Pt 7):2040-51. PubMed ID: 24866055
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.
    Andrade NS; Ramic M; Esanov R; Liu W; Rybin MJ; Gaidosh G; Abdallah A; Del'Olio S; Huff TC; Chee NT; Anatha S; Gendron TF; Wahlestedt C; Zhang Y; Benatar M; Mueller C; Zeier Z
    Mol Neurodegener; 2020 Feb; 15(1):13. PubMed ID: 32093728
    [TBL] [Abstract][Full Text] [Related]  

  • 9. C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration.
    May S; Hornburg D; Schludi MH; Arzberger T; Rentzsch K; Schwenk BM; Grässer FA; Mori K; Kremmer E; Banzhaf-Strathmann J; Mann M; Meissner F; Edbauer D
    Acta Neuropathol; 2014 Oct; 128(4):485-503. PubMed ID: 25120191
    [TBL] [Abstract][Full Text] [Related]  

  • 10. C9ORF72 dipeptide repeat poly-GA inclusions promote intracellular aggregation of phosphorylated TDP-43.
    Nonaka T; Masuda-Suzukake M; Hosokawa M; Shimozawa A; Hirai S; Okado H; Hasegawa M
    Hum Mol Genet; 2018 Aug; 27(15):2658-2670. PubMed ID: 29750243
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antibodies inhibit transmission and aggregation of
    Zhou Q; Lehmer C; Michaelsen M; Mori K; Alterauge D; Baumjohann D; Schludi MH; Greiling J; Farny D; Flatley A; Feederle R; May S; Schreiber F; Arzberger T; Kuhm C; Klopstock T; Hermann A; Haass C; Edbauer D
    EMBO Mol Med; 2017 May; 9(5):687-702. PubMed ID: 28351931
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.
    Mori K; Arzberger T; Grässer FA; Gijselinck I; May S; Rentzsch K; Weng SM; Schludi MH; van der Zee J; Cruts M; Van Broeckhoven C; Kremmer E; Kretzschmar HA; Haass C; Edbauer D
    Acta Neuropathol; 2013 Dec; 126(6):881-93. PubMed ID: 24132570
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.
    Kawabe Y; Mori K; Yamashita T; Gotoh S; Ikeda M
    EMBO J; 2020 Oct; 39(19):e102700. PubMed ID: 32830871
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
    Leskelä S; Huber N; Hoffmann D; Rostalski H; Remes AM; Takalo M; Hiltunen M; Haapasalo A
    Biochim Biophys Acta Mol Cell Res; 2021 Jun; 1868(7):119021. PubMed ID: 33775797
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration.
    Gomez-Deza J; Lee YB; Troakes C; Nolan M; Al-Sarraj S; Gallo JM; Shaw CE
    Acta Neuropathol Commun; 2015 Jun; 3():38. PubMed ID: 26108573
    [TBL] [Abstract][Full Text] [Related]  

  • 16. C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.
    Lee YB; Baskaran P; Gomez-Deza J; Chen HJ; Nishimura AL; Smith BN; Troakes C; Adachi Y; Stepto A; Petrucelli L; Gallo JM; Hirth F; Rogelj B; Guthrie S; Shaw CE
    Hum Mol Genet; 2017 Dec; 26(24):4765-4777. PubMed ID: 28973350
    [TBL] [Abstract][Full Text] [Related]  

  • 17. eIF5 stimulates the CUG initiation of RAN translation of poly-GA dipeptide repeat protein (DPR) in C9orf72 FTLD/ALS.
    Gotoh S; Mori K; Fujino Y; Kawabe Y; Yamashita T; Omi T; Nagata K; Tagami S; Nagai Y; Ikeda M
    J Biol Chem; 2024 Mar; 300(3):105703. PubMed ID: 38301895
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.
    Fifita JA; Zhang KY; Galper J; Williams KL; McCann EP; Hogan AL; Saunders N; Bauer D; Tarr IS; Pamphlett R; Nicholson GA; Rowe D; Yang S; Blair IP
    Neurodegener Dis; 2017; 17(6):304-312. PubMed ID: 29131108
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
    Farg MA; Konopka A; Soo KY; Ito D; Atkin JD
    Hum Mol Genet; 2017 Aug; 26(15):2882-2896. PubMed ID: 28481984
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
    Sonobe Y; Aburas J; Krishnan G; Fleming AC; Ghadge G; Islam P; Warren EC; Gu Y; Kankel MW; Brown AEX; Kiskinis E; Gendron TF; Gao FB; Roos RP; Kratsios P
    Nat Commun; 2021 Oct; 12(1):6025. PubMed ID: 34654821
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.