189 related articles for article (PubMed ID: 31649162)
1. Atorvastatin Targets the Islet Mevalonate Pathway to Dysregulate mTOR Signaling and Reduce β-Cell Functional Mass.
Shen L; Gu Y; Qiu Y; Cheng T; Nie A; Cui C; Fu C; Li T; Li X; Fu L; Wang Y; Ni Q; Wang Q; Wang W; Feng B
Diabetes; 2020 Jan; 69(1):48-59. PubMed ID: 31649162
[TBL] [Abstract][Full Text] [Related]
2. Statins inhibit blastocyst formation by preventing geranylgeranylation.
Alarcon VB; Marikawa Y
Mol Hum Reprod; 2016 May; 22(5):350-63. PubMed ID: 26908642
[TBL] [Abstract][Full Text] [Related]
3. Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
Gbelcová H; Rimpelová S; Knejzlík Z; Šáchová J; Kolář M; Strnad H; Repiská V; D'Acunto WC; Ruml T; Vítek L
Lipids Health Dis; 2017 Dec; 16(1):250. PubMed ID: 29262834
[TBL] [Abstract][Full Text] [Related]
4. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.
Tanaka T; Tatsuno I; Uchida D; Moroo I; Morio H; Nakamura S; Noguchi Y; Yasuda T; Kitagawa M; Saito Y; Hirai A
J Neurosci; 2000 Apr; 20(8):2852-9. PubMed ID: 10751437
[TBL] [Abstract][Full Text] [Related]
5. Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR.
Henriksbo BD; Tamrakar AK; Phulka JS; Barra NG; Schertzer JD
Am J Physiol Endocrinol Metab; 2020 Jul; 319(1):E110-E116. PubMed ID: 32421368
[TBL] [Abstract][Full Text] [Related]
6. Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes.
Godoy JC; Niesman IR; Busija AR; Kassan A; Schilling JM; Schwarz A; Alvarez EA; Dalton ND; Drummond JC; Roth DM; Kararigas G; Patel HH; Zemljic-Harpf AE
FASEB J; 2019 Jan; 33(1):1209-1225. PubMed ID: 30169110
[TBL] [Abstract][Full Text] [Related]
7. Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.
Alejandro EU; Bozadjieva N; Blandino-Rosano M; Wasan MA; Elghazi L; Vadrevu S; Satin L; Bernal-Mizrachi E
Diabetes; 2017 Aug; 66(8):2150-2162. PubMed ID: 28546423
[TBL] [Abstract][Full Text] [Related]
8. Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Zheng P; Zhang Q; Ma W; Hu R; Gu Y; Bian Z; Yang D; Chen X; Wu H
Eur J Pharmacol; 2023 Nov; 959():176085. PubMed ID: 37806539
[TBL] [Abstract][Full Text] [Related]
9. Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure.
Jalal MM; Whyte CS; Coxon FP; Mutch NJ
Platelets; 2023 Dec; 34(1):2206921. PubMed ID: 37139869
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.
Nomoto H; Kondo T; Miyoshi H; Nakamura A; Hida Y; Yamashita K; Sharma AJ; Atsumi T
Endocrinology; 2015 Oct; 156(10):3570-80. PubMed ID: 25763640
[TBL] [Abstract][Full Text] [Related]
11. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture.
Guijarro C; Blanco-Colio LM; Ortego M; Alonso C; Ortiz A; Plaza JJ; Díaz C; Hernández G; Egido J
Circ Res; 1998 Sep; 83(5):490-500. PubMed ID: 9734471
[TBL] [Abstract][Full Text] [Related]
12. Pioglitazone Ameliorates Atorvastatin-Induced Islet Cell Dysfunction through Activation of FFA1 in INS-1 Cells.
Zhu K; Qian L; Lin Y; An L; Mu G; Ma G; Ren L
J Diabetes Res; 2019; 2019():5245063. PubMed ID: 30863781
[TBL] [Abstract][Full Text] [Related]
13. Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways.
Siddals KW; Marshman E; Westwood M; Gibson JM
J Biol Chem; 2004 Sep; 279(37):38353-9. PubMed ID: 15247258
[TBL] [Abstract][Full Text] [Related]
14. PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.
Lakshmipathi J; Alvarez-Perez JC; Rosselot C; Casinelli GP; Stamateris RE; Rausell-Palamos F; O'Donnell CP; Vasavada RC; Scott DK; Alonso LC; Garcia-Ocaña A
Diabetes; 2016 May; 65(5):1283-96. PubMed ID: 26868297
[TBL] [Abstract][Full Text] [Related]
15. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation.
Blanco-Colio LM; Villa A; Ortego M; Hernández-Presa MA; Pascual A; Plaza JJ; Egido J
Atherosclerosis; 2002 Mar; 161(1):17-26. PubMed ID: 11882313
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo.
Sharon C; Baranwal S; Patel NJ; Rodriguez-Agudo D; Pandak WM; Majumdar AP; Krystal G; Patel BB
Oncotarget; 2015 Jun; 6(17):15332-47. PubMed ID: 25895029
[TBL] [Abstract][Full Text] [Related]
17. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.
Lee MH; Cho YS; Han YM
Stem Cells; 2007 Jul; 25(7):1654-63. PubMed ID: 17464088
[TBL] [Abstract][Full Text] [Related]
18. Mevalonate Cascade and its Regulation in Cholesterol Metabolism in Different Tissues in Health and Disease.
Hashemi M; Hoshyar R; Ande SR; Chen QM; Solomon C; Zuse A; Naderi M
Curr Mol Pharmacol; 2017; 10(1):13-26. PubMed ID: 26758949
[TBL] [Abstract][Full Text] [Related]
19. Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer.
Göbel A; Zinna VM; Dell'Endice S; Jaschke N; Kuhlmann JD; Wimberger P; Rachner TD
BMC Cancer; 2020 Jul; 20(1):703. PubMed ID: 32727400
[TBL] [Abstract][Full Text] [Related]
20. Interactions between Atorvastatin and the Farnesoid X Receptor Impair Insulinotropic Effects of Bile Acids and Modulate Diabetogenic Risk.
Hoffmeister T; Kaiser J; Lüdtke S; Drews G; Düfer M
Mol Pharmacol; 2020 Mar; 97(3):202-211. PubMed ID: 31911428
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
