299 related articles for article (PubMed ID: 31663853)
1. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.
Berndsen K; Lis P; Yeshaw WM; Wawro PS; Nirujogi RS; Wightman M; Macartney T; Dorward M; Knebel A; Tonelli F; Pfeffer SR; Alessi DR
Elife; 2019 Oct; 8():. PubMed ID: 31663853
[TBL] [Abstract][Full Text] [Related]
2. Structural basis for the specificity of PPM1H phosphatase for Rab GTPases.
Waschbüsch D; Berndsen K; Lis P; Knebel A; Lam YP; Alessi DR; Khan AR
EMBO Rep; 2021 Nov; 22(11):e52675. PubMed ID: 34580980
[TBL] [Abstract][Full Text] [Related]
3. Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.
Yeshaw WM; Adhikari A; Chiang CY; Dhekne HS; Wawro PS; Pfeffer SR
Proc Natl Acad Sci U S A; 2023 Oct; 120(44):e2315171120. PubMed ID: 37889931
[TBL] [Abstract][Full Text] [Related]
4. Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Malik AU; Karapetsas A; Nirujogi RS; Mathea S; Chatterjee D; Pal P; Lis P; Taylor M; Purlyte E; Gourlay R; Dorward M; Weidlich S; Toth R; Polinski NK; Knapp S; Tonelli F; Alessi DR
Biochem J; 2021 Feb; 478(3):553-578. PubMed ID: 33459343
[TBL] [Abstract][Full Text] [Related]
5. Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
Dhekne HS; Tonelli F; Yeshaw WM; Chiang CY; Limouse C; Jaimon E; Purlyte E; Alessi DR; Pfeffer SR
Elife; 2023 Oct; 12():. PubMed ID: 37874635
[TBL] [Abstract][Full Text] [Related]
6. Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Steger M; Diez F; Dhekne HS; Lis P; Nirujogi RS; Karayel O; Tonelli F; Martinez TN; Lorentzen E; Pfeffer SR; Alessi DR; Mann M
Elife; 2017 Nov; 6():. PubMed ID: 29125462
[TBL] [Abstract][Full Text] [Related]
7. Development of phospho-specific Rab protein antibodies to monitor
Lis P; Burel S; Steger M; Mann M; Brown F; Diez F; Tonelli F; Holton JL; Ho PW; Ho SL; Chou MY; Polinski NK; Martinez TN; Davies P; Alessi DR
Biochem J; 2018 Jan; 475(1):1-22. PubMed ID: 29127256
[TBL] [Abstract][Full Text] [Related]
8. LRRK2 and Rab GTPases.
Pfeffer SR
Biochem Soc Trans; 2018 Dec; 46(6):1707-1712. PubMed ID: 30467121
[TBL] [Abstract][Full Text] [Related]
9. Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.
Dou D; Smith EM; Evans CS; Boecker CA; Holzbaur ELF
Cell Rep; 2023 May; 42(5):112448. PubMed ID: 37133994
[TBL] [Abstract][Full Text] [Related]
10. LRRK2 phosphorylation of Rab GTPases in Parkinson's disease.
Pfeffer SR
FEBS Lett; 2023 Mar; 597(6):811-818. PubMed ID: 36114007
[TBL] [Abstract][Full Text] [Related]
11. PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
Vieweg S; Mulholland K; Bräuning B; Kachariya N; Lai YC; Toth R; Singh PK; Volpi I; Sattler M; Groll M; Itzen A; Muqit MMK
Biochem J; 2020 May; 477(9):1651-1668. PubMed ID: 32227113
[TBL] [Abstract][Full Text] [Related]
12. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
Ito G; Katsemonova K; Tonelli F; Lis P; Baptista MA; Shpiro N; Duddy G; Wilson S; Ho PW; Ho SL; Reith AD; Alessi DR
Biochem J; 2016 Sep; 473(17):2671-85. PubMed ID: 27474410
[TBL] [Abstract][Full Text] [Related]
13. A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
Dhekne HS; Yanatori I; Gomez RC; Tonelli F; Diez F; Schüle B; Steger M; Alessi DR; Pfeffer SR
Elife; 2018 Nov; 7():. PubMed ID: 30398148
[TBL] [Abstract][Full Text] [Related]
14. Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites.
Nirujogi RS; Tonelli F; Taylor M; Lis P; Zimprich A; Sammler E; Alessi DR
Biochem J; 2021 Jan; 478(2):299-326. PubMed ID: 33367571
[TBL] [Abstract][Full Text] [Related]
15. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Mir R; Tonelli F; Lis P; Macartney T; Polinski NK; Martinez TN; Chou MY; Howden AJM; König T; Hotzy C; Milenkovic I; Brücke T; Zimprich A; Sammler E; Alessi DR
Biochem J; 2018 Jun; 475(11):1861-1883. PubMed ID: 29743203
[TBL] [Abstract][Full Text] [Related]
16. Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.
Khan SS; Sobu Y; Dhekne HS; Tonelli F; Berndsen K; Alessi DR; Pfeffer SR
Elife; 2021 Oct; 10():. PubMed ID: 34658337
[TBL] [Abstract][Full Text] [Related]
17. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
Kalogeropulou AF; Freemantle JB; Lis P; Vides EG; Polinski NK; Alessi DR
Biochem J; 2020 Nov; 477(22):4397-4423. PubMed ID: 33135724
[TBL] [Abstract][Full Text] [Related]
18. A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation.
Vides EG; Adhikari A; Chiang CY; Lis P; Purlyte E; Limouse C; Shumate JL; Spínola-Lasso E; Dhekne HS; Alessi DR; Pfeffer SR
Elife; 2022 Sep; 11():. PubMed ID: 36149401
[TBL] [Abstract][Full Text] [Related]
19. Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.
Jeong GR; Jang EH; Bae JR; Jun S; Kang HC; Park CH; Shin JH; Yamamoto Y; Tanaka-Yamamoto K; Dawson VL; Dawson TM; Hur EM; Lee BD
Mol Neurodegener; 2018 Feb; 13(1):8. PubMed ID: 29439717
[TBL] [Abstract][Full Text] [Related]
20. Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Steger M; Tonelli F; Ito G; Davies P; Trost M; Vetter M; Wachter S; Lorentzen E; Duddy G; Wilson S; Baptista MA; Fiske BK; Fell MJ; Morrow JA; Reith AD; Alessi DR; Mann M
Elife; 2016 Jan; 5():. PubMed ID: 26824392
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]