These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

220 related articles for article (PubMed ID: 31676453)

  • 1. Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.
    Masaracchia C; König A; Valiente-Gabioud AA; Peralta P; Favretto F; Strohäker T; Lázaro DF; Zweckstetter M; Fernandez CO; Outeiro TF
    Biochim Biophys Acta Proteins Proteom; 2020 Jan; 1868(1):140298. PubMed ID: 31676453
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation.
    Lázaro DF; Dias MC; Carija A; Navarro S; Madaleno CS; Tenreiro S; Ventura S; Outeiro TF
    Acta Neuropathol Commun; 2016 Dec; 4(1):128. PubMed ID: 27938414
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Membrane binding, internalization, and sorting of alpha-synuclein in the cell.
    Masaracchia C; Hnida M; Gerhardt E; Lopes da Fonseca T; Villar-Pique A; Branco T; Stahlberg MA; Dean C; Fernández CO; Milosevic I; Outeiro TF
    Acta Neuropathol Commun; 2018 Aug; 6(1):79. PubMed ID: 30107856
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.
    Ysselstein D; Dehay B; Costantino IM; McCabe GP; Frosch MP; George JM; Bezard E; Rochet JC
    Acta Neuropathol Commun; 2017 Jan; 5(1):3. PubMed ID: 28069058
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight.
    Al-Azzani M; König A; Outeiro TF
    Biomolecules; 2022 Feb; 12(2):. PubMed ID: 35204823
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein.
    Landeck N; Strathearn KE; Ysselstein D; Buck K; Dutta S; Banerjee S; Lv Z; Hulleman JD; Hindupur J; Lin LK; Padalkar S; Stanciu LA; Lyubchenko YL; Kirik D; Rochet JC
    Mol Neurodegener; 2020 Sep; 15(1):49. PubMed ID: 32900375
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.
    Villar-Piqué A; Lopes da Fonseca T; Sant'Anna R; Szegö ÉM; Fonseca-Ornelas L; Pinho R; Carija A; Gerhardt E; Masaracchia C; Abad Gonzalez E; Rossetti G; Carloni P; Fernández CO; Foguel D; Milosevic I; Zweckstetter M; Ventura S; Outeiro TF
    Proc Natl Acad Sci U S A; 2016 Oct; 113(42):E6506-E6515. PubMed ID: 27708160
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
    Lázaro DF; Rodrigues EF; Langohr R; Shahpasandzadeh H; Ribeiro T; Guerreiro P; Gerhardt E; Kröhnert K; Klucken J; Pereira MD; Popova B; Kruse N; Mollenhauer B; Rizzoli SO; Braus GH; Danzer KM; Outeiro TF
    PLoS Genet; 2014 Nov; 10(11):e1004741. PubMed ID: 25393002
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.
    Price DL; Koike MA; Khan A; Wrasidlo W; Rockenstein E; Masliah E; Bonhaus D
    Sci Rep; 2018 Nov; 8(1):16165. PubMed ID: 30385782
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism.
    Tao J; Berthet A; Citron YR; Tsiolaki PL; Stanley R; Gestwicki JE; Agard DA; McConlogue L
    J Biol Chem; 2021; 296():100613. PubMed ID: 33798554
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanisms of alpha-synuclein toxicity: An update and outlook.
    Brás IC; Xylaki M; Outeiro TF
    Prog Brain Res; 2020; 252():91-129. PubMed ID: 32247376
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease.
    Gonçalves SA; Outeiro TF
    Small GTPases; 2017 Apr; 8(2):78-84. PubMed ID: 27314512
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation.
    Chlebowicz J; Russ W; Chen D; Vega A; Vernino S; White CL; Rizo J; Joachimiak LA; Diamond MI
    Sci Adv; 2023 Oct; 9(43):eadh3457. PubMed ID: 37889966
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity.
    Ysselstein D; Joshi M; Mishra V; Griggs AM; Asiago JM; McCabe GP; Stanciu LA; Post CB; Rochet JC
    Neurobiol Dis; 2015 Jul; 79():150-63. PubMed ID: 25931201
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The differential solvent exposure of N-terminal residues provides "fingerprints" of alpha-synuclein fibrillar polymorphs.
    Landureau M; Redeker V; Bellande T; Eyquem S; Melki R
    J Biol Chem; 2021; 296():100737. PubMed ID: 33933456
    [TBL] [Abstract][Full Text] [Related]  

  • 16. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.
    Gonçalves SA; Macedo D; Raquel H; Simões PD; Giorgini F; Ramalho JS; Barral DC; Ferreira Moita L; Outeiro TF
    PLoS Genet; 2016 Apr; 12(4):e1005995. PubMed ID: 27123591
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PrP meets alpha-synuclein: Molecular mechanisms and implications for disease.
    Vieira TCRG; Barros CA; Domingues R; Outeiro TF
    J Neurochem; 2024 Aug; 168(8):1625-1639. PubMed ID: 37855859
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models.
    Vinueza-Gavilanes R; Bravo-González JJ; Basurco L; Boncristiani C; Fernández-Irigoyen J; Santamaría E; Marcilla I; Pérez-Mediavilla A; Luquin MR; Vales A; González-Aseguinolaza G; Aymerich MS; Aragón T; Arrasate M
    Neurobiol Dis; 2023 Jul; 183():106166. PubMed ID: 37245833
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.
    Hoffmann AC; Minakaki G; Menges S; Salvi R; Savitskiy S; Kazman A; Vicente Miranda H; Mielenz D; Klucken J; Winkler J; Xiang W
    Sci Rep; 2019 Jan; 9(1):544. PubMed ID: 30679445
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports.
    Lashuel HA
    Neurobiol Dis; 2020 Jul; 141():104876. PubMed ID: 32339655
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.