222 related articles for article (PubMed ID: 31704718)
21. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors.
Croy CH; Schober DA; Xiao H; Quets A; Christopoulos A; Felder CC
Mol Pharmacol; 2014 Jul; 86(1):106-15. PubMed ID: 24807965
[TBL] [Abstract][Full Text] [Related]
22. Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Vuckovic Z; Wang J; Pham V; Mobbs JI; Belousoff MJ; Bhattarai A; Burger WAC; Thompson G; Yeasmin M; Nawaratne V; Leach K; van der Westhuizen ET; Khajehali E; Liang YL; Glukhova A; Wootten D; Lindsley CW; Tobin A; Sexton P; Danev R; Valant C; Miao Y; Christopoulos A; Thal DM
Elife; 2023 May; 12():. PubMed ID: 37248726
[TBL] [Abstract][Full Text] [Related]
23. Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms.
Keller AN; Kufareva I; Josephs TM; Diao J; Mai VT; Conigrave AD; Christopoulos A; Gregory KJ; Leach K
Mol Pharmacol; 2018 Jun; 93(6):619-630. PubMed ID: 29636377
[TBL] [Abstract][Full Text] [Related]
24. International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function.
Leach K; Hannan FM; Josephs TM; Keller AN; Møller TC; Ward DT; Kallay E; Mason RS; Thakker RV; Riccardi D; Conigrave AD; Bräuner-Osborne H
Pharmacol Rev; 2020 Jul; 72(3):558-604. PubMed ID: 32467152
[TBL] [Abstract][Full Text] [Related]
25. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
Thal DM; Sun B; Feng D; Nawaratne V; Leach K; Felder CC; Bures MG; Evans DA; Weis WI; Bachhawat P; Kobilka TS; Sexton PM; Kobilka BK; Christopoulos A
Nature; 2016 Mar; 531(7594):335-40. PubMed ID: 26958838
[TBL] [Abstract][Full Text] [Related]
26. Quantifying biological activity in chemical terms: a pharmacology primer to describe drug effect.
Kenakin T
ACS Chem Biol; 2009 Apr; 4(4):249-60. PubMed ID: 19193052
[TBL] [Abstract][Full Text] [Related]
27. Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors.
Schwartz TW; Holst B
J Recept Signal Transduct Res; 2006; 26(1-2):107-28. PubMed ID: 16595341
[TBL] [Abstract][Full Text] [Related]
28. Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects.
Valant C; Felder CC; Sexton PM; Christopoulos A
Mol Pharmacol; 2012 Jan; 81(1):41-52. PubMed ID: 21989256
[TBL] [Abstract][Full Text] [Related]
29. "Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu
Hellyer SD; Albold S; Wang T; Chen ANY; May LT; Leach K; Gregory KJ
Mol Pharmacol; 2018 May; 93(5):504-514. PubMed ID: 29514854
[TBL] [Abstract][Full Text] [Related]
30. Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor.
Saleh N; Hucke O; Kramer G; Schmidt E; Montel F; Lipinski R; Ferger B; Clark T; Hildebrand PW; Tautermann CS
Angew Chem Int Ed Engl; 2018 Mar; 57(10):2580-2585. PubMed ID: 29314474
[TBL] [Abstract][Full Text] [Related]
31. The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor.
Leach K; Davey AE; Felder CC; Sexton PM; Christopoulos A
Mol Pharmacol; 2011 May; 79(5):855-65. PubMed ID: 21300722
[TBL] [Abstract][Full Text] [Related]
32. Regulation of signal transduction at M2 muscarinic receptor.
Krejcí A; Michal P; Jakubík J; Rícný J; Dolezal V
Physiol Res; 2004; 53 Suppl 1():S131-40. PubMed ID: 15119944
[TBL] [Abstract][Full Text] [Related]
33. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).
Turlington M; Noetzel MJ; Chun A; Zhou Y; Gogliotti RD; Nguyen ED; Gregory KJ; Vinson PN; Rook JM; Gogi KK; Xiang Z; Bridges TM; Daniels JS; Jones C; Niswender CM; Meiler J; Conn PJ; Lindsley CW; Stauffer SR
J Med Chem; 2013 Oct; 56(20):7976-96. PubMed ID: 24050755
[TBL] [Abstract][Full Text] [Related]
34. Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles.
Rook JM; Tantawy MN; Ansari MS; Felts AS; Stauffer SR; Emmitte KA; Kessler RM; Niswender CM; Daniels JS; Jones CK; Lindsley CW; Conn PJ
Neuropsychopharmacology; 2015 Feb; 40(3):755-65. PubMed ID: 25241804
[TBL] [Abstract][Full Text] [Related]
35. Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
Jakubík J; Bacáková L; El-Fakahany EE; Tucek S
Mol Pharmacol; 1997 Jul; 52(1):172-9. PubMed ID: 9224827
[TBL] [Abstract][Full Text] [Related]
36. Allosteric interactions at muscarinic cholinoceptors.
Christopoulos A; Lanzafame A; Mitchelson F
Clin Exp Pharmacol Physiol; 1998; 25(3-4):185-94. PubMed ID: 9590567
[TBL] [Abstract][Full Text] [Related]
37. Discovery and Development of Muscarinic Acetylcholine M
Takai K; Enomoto T
Chem Pharm Bull (Tokyo); 2018; 66(1):37-44. PubMed ID: 29311510
[TBL] [Abstract][Full Text] [Related]
38. When simple agonism is not enough: emerging modalities of GPCR ligands.
Smith NJ; Bennett KA; Milligan G
Mol Cell Endocrinol; 2011 Jan; 331(2):241-7. PubMed ID: 20654693
[TBL] [Abstract][Full Text] [Related]
39. Detection and quantification of allosteric modulation of endogenous m4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line.
Chen AN; Malone DT; Pabreja K; Sexton PM; Christopoulos A; Canals M
J Biomol Screen; 2015 Jun; 20(5):646-54. PubMed ID: 25534830
[TBL] [Abstract][Full Text] [Related]
40. Estimation of ligand affinity constants for receptor states in functional studies involving the allosteric modulation of G protein-coupled receptors: implications for ligand bias.
Ehlert FJ; Griffin MT
J Pharmacol Toxicol Methods; 2014; 69(3):253-79. PubMed ID: 24434717
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]