275 related articles for article (PubMed ID: 31707708)
1. Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling.
Leroux AE; Gross LZF; Sacerdoti M; Biondi RM
Adv Exp Med Biol; 2019; 1163():279-311. PubMed ID: 31707708
[TBL] [Abstract][Full Text] [Related]
2. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Schulze JO; Saladino G; Busschots K; Neimanis S; Süß E; Odadzic D; Zeuzem S; Hindie V; Herbrand AK; Lisa MN; Alzari PM; Gervasio FL; Biondi RM
Cell Chem Biol; 2016 Oct; 23(10):1193-1205. PubMed ID: 27693059
[TBL] [Abstract][Full Text] [Related]
3. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Rettenmaier TJ; Sadowsky JD; Thomsen ND; Chen SC; Doak AK; Arkin MR; Wells JA
Proc Natl Acad Sci U S A; 2014 Dec; 111(52):18590-5. PubMed ID: 25518860
[TBL] [Abstract][Full Text] [Related]
4. AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.
Arencibia JM; Pastor-Flores D; Bauer AF; Schulze JO; Biondi RM
Biochim Biophys Acta; 2013 Jul; 1834(7):1302-21. PubMed ID: 23524293
[TBL] [Abstract][Full Text] [Related]
5. Use of a fluorescent ATP analog to probe the allosteric conformational change in the active site of the protein kinase PDK1.
Hindie V; Lopez-Garcia LA; Biondi RM
Methods Mol Biol; 2012; 928():133-41. PubMed ID: 22956138
[TBL] [Abstract][Full Text] [Related]
6. AGC kinases, mechanisms of regulation and innovative drug development.
Leroux AE; Schulze JO; Biondi RM
Semin Cancer Biol; 2018 Feb; 48():1-17. PubMed ID: 28591657
[TBL] [Abstract][Full Text] [Related]
7. Renaissance of Allostery to Disrupt Protein Kinase Interactions.
Leroux AE; Biondi RM
Trends Biochem Sci; 2020 Jan; 45(1):27-41. PubMed ID: 31690482
[TBL] [Abstract][Full Text] [Related]
8. Discovery of SBF1 as an allosteric inhibitor targeting the PIF-pocket of 3-phosphoinositide-dependent protein kinase-1.
Liu W; Li P; Mei Y
J Mol Model; 2019 Jun; 25(7):187. PubMed ID: 31197600
[TBL] [Abstract][Full Text] [Related]
9. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.
Panicker RC; Chattopadhaya S; Coyne AG; Srinivasan R
Adv Exp Med Biol; 2019; 1163():253-278. PubMed ID: 31707707
[TBL] [Abstract][Full Text] [Related]
10. The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1.
Xu X; Chen Y; Fu Q; Ni D; Zhang J; Li X; Lu S
J Enzyme Inhib Med Chem; 2019 Dec; 34(1):361-374. PubMed ID: 30734603
[TBL] [Abstract][Full Text] [Related]
11. Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
Sadowsky JD; Burlingame MA; Wolan DW; McClendon CL; Jacobson MP; Wells JA
Proc Natl Acad Sci U S A; 2011 Apr; 108(15):6056-61. PubMed ID: 21430264
[TBL] [Abstract][Full Text] [Related]
12. Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments.
Stockman BJ; Kothe M; Kohls D; Weibley L; Connolly BJ; Sheils AL; Cao Q; Cheng AC; Yang L; Kamath AV; Ding YH; Charlton ME
Chem Biol Drug Des; 2009 Feb; 73(2):179-88. PubMed ID: 19207420
[TBL] [Abstract][Full Text] [Related]
13. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.
Busschots K; Lopez-Garcia LA; Lammi C; Stroba A; Zeuzem S; Piiper A; Alzari PM; Neimanis S; Arencibia JM; Engel M; Schulze JO; Biondi RM
Chem Biol; 2012 Sep; 19(9):1152-63. PubMed ID: 22999883
[TBL] [Abstract][Full Text] [Related]
14. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.
Hindie V; Stroba A; Zhang H; Lopez-Garcia LA; Idrissova L; Zeuzem S; Hirschberg D; Schaeffer F; Jørgensen TJ; Engel M; Alzari PM; Biondi RM
Nat Chem Biol; 2009 Oct; 5(10):758-64. PubMed ID: 19718043
[TBL] [Abstract][Full Text] [Related]
15. Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket.
Lopez-Garcia LA; Schulze JO; Fröhner W; Zhang H; Süss E; Weber N; Navratil J; Amon S; Hindie V; Zeuzem S; Jørgensen TJ; Alzari PM; Neimanis S; Engel M; Biondi RM
Chem Biol; 2011 Nov; 18(11):1463-73. PubMed ID: 22118680
[TBL] [Abstract][Full Text] [Related]
16. A patent update on PDK1 inhibitors (2015-present).
Sestito S; Rapposelli S
Expert Opin Ther Pat; 2019 Apr; 29(4):271-282. PubMed ID: 30897008
[TBL] [Abstract][Full Text] [Related]
17. Synergistic Allostery in Multiligand-Protein Interactions.
Ghode A; Gross LZF; Tee WV; Guarnera E; Berezovsky IN; Biondi RM; Anand GS
Biophys J; 2020 Nov; 119(9):1833-1848. PubMed ID: 33086047
[TBL] [Abstract][Full Text] [Related]
18. Protein Allostery in Rational Drug Design.
Kinoshita T
Adv Exp Med Biol; 2019; 1163():45-64. PubMed ID: 31707699
[TBL] [Abstract][Full Text] [Related]
19. Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
Panicker RC; Coyne AG; Srinivasan R
Curr Med Chem; 2019; 26(13):2234-2242. PubMed ID: 28748768
[TBL] [Abstract][Full Text] [Related]
20. αC helix displacement as a general approach for allosteric modulation of protein kinases.
Palmieri L; Rastelli G
Drug Discov Today; 2013 Apr; 18(7-8):407-14. PubMed ID: 23195331
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]