145 related articles for article (PubMed ID: 31712618)
1. Binding and structural analyses of potent inhibitors of the human Ca
Profeta GS; Dos Reis CV; Santiago ADS; Godoi PHC; Fala AM; Wells CI; Sartori R; Salmazo APT; Ramos PZ; Massirer KB; Elkins JM; Drewry DH; Gileadi O; Couñago RM
Sci Rep; 2019 Nov; 9(1):16452. PubMed ID: 31712618
[TBL] [Abstract][Full Text] [Related]
2. Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.
Santiago ADS; Couñago RM; Ramos PZ; Godoi PHC; Massirer KB; Gileadi O; Elkins JM
Sci Rep; 2018 Oct; 8(1):14800. PubMed ID: 30287839
[TBL] [Abstract][Full Text] [Related]
3. CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert.
Kylarova S; Psenakova K; Herman P; Obsilova V; Obsil T
Biochim Biophys Acta Gen Subj; 2018 Oct; 1862(10):2304-2313. PubMed ID: 30053538
[TBL] [Abstract][Full Text] [Related]
4. Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2.
Gerner L; Munack S; Temmerman K; Lawrence-Dörner AM; Besir H; Wilmanns M; Jensen JK; Thiede B; Mills IG; Morth JP
Biochem Biophys Res Commun; 2016 Jul; 476(2):102-7. PubMed ID: 27178209
[TBL] [Abstract][Full Text] [Related]
5. 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.
Asquith CRM; Godoi PH; Couñago RM; Laitinen T; Scott JW; Langendorf CG; Oakhill JS; Drewry DH; Zuercher WJ; Koutentis PA; Willson TM; Kalogirou AS
Molecules; 2018 May; 23(5):. PubMed ID: 29783765
[TBL] [Abstract][Full Text] [Related]
6. Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
Eduful BJ; O'Byrne SN; Temme L; Asquith CRM; Liang Y; Picado A; Pilotte JR; Hossain MA; Wells CI; Zuercher WJ; Catta-Preta CMC; Zonzini Ramos P; Santiago AS; Couñago RM; Langendorf CG; Nay K; Oakhill JS; Pulliam TL; Lin C; Awad D; Willson TM; Frigo DE; Scott JW; Drewry DH
J Med Chem; 2021 Aug; 64(15):10849-10877. PubMed ID: 34264658
[TBL] [Abstract][Full Text] [Related]
7. 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2).
Psenakova K; Petrvalska O; Kylarova S; Lentini Santo D; Kalabova D; Herman P; Obsilova V; Obsil T
Biochim Biophys Acta Gen Subj; 2018 Jul; 1862(7):1612-1625. PubMed ID: 29649512
[TBL] [Abstract][Full Text] [Related]
8. In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.
O'Byrne SN; Scott JW; Pilotte JR; Santiago ADS; Langendorf CG; Oakhill JS; Eduful BJ; Couñago RM; Wells CI; Zuercher WJ; Willson TM; Drewry DH
Molecules; 2020 Jan; 25(2):. PubMed ID: 31941153
[TBL] [Abstract][Full Text] [Related]
9. 14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices.
Petrvalska O; Honzejkova K; Koupilova N; Herman P; Obsilova V; Obsil T
Protein Sci; 2023 Nov; 32(11):e4805. PubMed ID: 37817008
[TBL] [Abstract][Full Text] [Related]
10. Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2).
Chen Y; Whitefield B; Nevius E; Hill M; DelRosario J; Sinitsyna N; Shanmugasundaram V; Mukherjee D; Shi L; Mayne CG; Rousseau AM; Bernard SM; Buenviaje J; Khambatta G; El Samin M; Wallace M; Nie Z; Sivakumar P; Hamann LG; McDonnell DP; D'Agostino LA
J Med Chem; 2023 Dec; 66(23):15750-15760. PubMed ID: 38009718
[TBL] [Abstract][Full Text] [Related]
11. Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
Lentini Santo D; Petrvalska O; Obsilova V; Ottmann C; Obsil T
ACS Chem Biol; 2020 Nov; 15(11):3060-3071. PubMed ID: 33146997
[TBL] [Abstract][Full Text] [Related]
12. Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) inhibitors: a novel approach in small molecule discovery.
Devasahayam Arokia Balaya R; Chandrasekaran J; Kanekar S; Kumar Modi P; Dagamajalu S; Gopinathan K; Raju R; Prasad TSK
J Biomol Struct Dyn; 2023; 41(24):15196-15206. PubMed ID: 37029757
[TBL] [Abstract][Full Text] [Related]
13. Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609.
Kukimoto-Niino M; Yoshikawa S; Takagi T; Ohsawa N; Tomabechi Y; Terada T; Shirouzu M; Suzuki A; Lee S; Yamauchi T; Okada-Iwabu M; Iwabu M; Kadowaki T; Minokoshi Y; Yokoyama S
J Biol Chem; 2011 Jun; 286(25):22570-9. PubMed ID: 21504895
[TBL] [Abstract][Full Text] [Related]
14. Impact of Genetic Variation on Human CaMKK2 Regulation by Ca
O'Brien MT; Oakhill JS; Ling NX; Langendorf CG; Hoque A; Dite TA; Means AR; Kemp BE; Scott JW
Sci Rep; 2017 Feb; 7():43264. PubMed ID: 28230171
[TBL] [Abstract][Full Text] [Related]
15. CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins.
Langendorf CG; O'Brien MT; Ngoei KRW; McAloon LM; Dhagat U; Hoque A; Ling NXY; Dite TA; Galic S; Loh K; Parker MW; Oakhill JS; Kemp BE; Scott JW
J Biol Chem; 2020 Nov; 295(48):16239-16250. PubMed ID: 32913128
[TBL] [Abstract][Full Text] [Related]
16. Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs) Effects on AMP-Activated Protein Kinase (AMPK) Regulation of Chicken Sperm Functions.
Nguyen TM; Combarnous Y; Praud C; Duittoz A; Blesbois E
PLoS One; 2016; 11(1):e0147559. PubMed ID: 26808520
[TBL] [Abstract][Full Text] [Related]
17. Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
Takaya D; Niwa H; Mikuni J; Nakamura K; Handa N; Tanaka A; Yokoyama S; Honma T
J Mol Graph Model; 2020 Sep; 99():107599. PubMed ID: 32348940
[TBL] [Abstract][Full Text] [Related]
18. Effects of Single-Nucleotide Polymorphisms in Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2): A Comprehensive Study.
Khalid Z; Almaghrabi O
Comput Math Methods Med; 2020; 2020():7419512. PubMed ID: 33082841
[TBL] [Abstract][Full Text] [Related]
19. Functional analysis of an R311C variant of Ca
Xy Ling N; Langendorf CG; Hoque A; Galic S; Loh K; Kemp BE; Gundlach AL; Oakhill JS; Scott JW
Bipolar Disord; 2020 Dec; 22(8):841-848. PubMed ID: 32216002
[TBL] [Abstract][Full Text] [Related]
20. Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.
Nanba K; Chen A; Nishimoto K; Rainey WE
Endocrinology; 2015 May; 156(5):1750-6. PubMed ID: 25679868
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]