BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 31721563)

  • 1. Functional and Structural Analyses of the Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin.
    Kawasaki D; Miyanaga A; Chisuga T; Kudo F; Eguchi T
    Biochemistry; 2019 Dec; 58(48):4799-4803. PubMed ID: 31721563
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of the enzymatic domains in the modular polyketide synthase involved in rifamycin B biosynthesis by Amycolatopsis mediterranei.
    Tang L; Yoon YJ; Choi CY; Hutchinson CR
    Gene; 1998 Aug; 216(2):255-65. PubMed ID: 9729415
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS.
    Musiol EM; Härtner T; Kulik A; Moldenhauer J; Piel J; Wohlleben W; Weber T
    Chem Biol; 2011 Apr; 18(4):438-44. PubMed ID: 21513880
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.
    Wu J; Zaleski TJ; Valenzano C; Khosla C; Cane DE
    J Am Chem Soc; 2005 Dec; 127(49):17393-404. PubMed ID: 16332089
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Type I polyketide synthases that require discrete acyltransferases.
    Cheng YQ; Coughlin JM; Lim SK; Shen B
    Methods Enzymol; 2009; 459():165-86. PubMed ID: 19362640
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase.
    Wang F; Wang Y; Ji J; Zhou Z; Yu J; Zhu H; Su Z; Zhang L; Zheng J
    ACS Chem Biol; 2015 Apr; 10(4):1017-25. PubMed ID: 25581064
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases.
    Barajas JF; McAndrew RP; Thompson MG; Backman TWH; Pang B; de Rond T; Pereira JH; Benites VT; Martín HG; Baidoo EEK; Hillson NJ; Adams PD; Keasling JD
    J Ind Microbiol Biotechnol; 2019 Aug; 46(8):1225-1235. PubMed ID: 31115703
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comprehensive in Vitro Analysis of Acyltransferase Domain Exchanges in Modular Polyketide Synthases and Its Application for Short-Chain Ketone Production.
    Yuzawa S; Deng K; Wang G; Baidoo EE; Northen TR; Adams PD; Katz L; Keasling JD
    ACS Synth Biol; 2017 Jan; 6(1):139-147. PubMed ID: 27548700
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases.
    Dunn BJ; Watts KR; Robbins T; Cane DE; Khosla C
    Biochemistry; 2014 Jun; 53(23):3796-806. PubMed ID: 24871074
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
    Zhang F; Shi T; Ji H; Ali I; Huang S; Deng Z; Min Q; Bai L; Zhao Y; Zheng J
    Biochemistry; 2019 Jul; 58(27):2978-2986. PubMed ID: 31199122
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A unique amino transfer mechanism for constructing the β-amino fatty acid starter unit in the biosynthesis of the macrolactam antibiotic cremimycin.
    Amagai K; Takaku R; Kudo F; Eguchi T
    Chembiochem; 2013 Oct; 14(15):1998-2006. PubMed ID: 24014395
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rational engineering acyltransferase domain of modular polyketide synthase for expanding substrate specificity.
    Zhang W; Zhou L; Li C; Deng Z; Qu X
    Methods Enzymol; 2019; 622():271-292. PubMed ID: 31155056
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis.
    Jenke-Kodama H; Börner T; Dittmann E
    PLoS Comput Biol; 2006 Oct; 2(10):e132. PubMed ID: 17029557
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The AT₂ domain of KirCI loads malonyl extender units to the ACPs of the kirromycin PKS.
    Musiol EM; Greule A; Härtner T; Kulik A; Wohlleben W; Weber T
    Chembiochem; 2013 Jul; 14(11):1343-52. PubMed ID: 23828654
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanisms of molecular recognition in the pikromycin polyketide synthase.
    Chen S; Xue Y; Sherman DH; Reynolds KA
    Chem Biol; 2000 Dec; 7(12):907-18. PubMed ID: 11137814
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
    Jørgensen H; Degnes KF; Sletta H; Fjaervik E; Dikiy A; Herfindal L; Bruheim P; Klinkenberg G; Bredholt H; Nygård G; Døskeland SO; Ellingsen TE; Zotchev SB
    Chem Biol; 2009 Oct; 16(10):1109-21. PubMed ID: 19875084
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical characterization of a malonyl-specific acyltransferase domain of FK506 biosynthetic polyketide synthase.
    Wang YY; Bai LF; Ran XX; Jiang XH; Wu H; Zhang W; Jin MY; Li YQ; Jiang H
    Protein Pept Lett; 2015; 22(1):2-7. PubMed ID: 25267255
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.
    Koryakina I; Kasey C; McArthur JB; Lowell AN; Chemler JA; Li S; Hansen DA; Sherman DH; Williams GJ
    ACS Chem Biol; 2017 Jan; 12(1):114-123. PubMed ID: 28103677
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural rearrangements of a polyketide synthase module during its catalytic cycle.
    Whicher JR; Dutta S; Hansen DA; Hale WA; Chemler JA; Dosey AM; Narayan AR; Håkansson K; Sherman DH; Smith JL; Skiniotis G
    Nature; 2014 Jun; 510(7506):560-4. PubMed ID: 24965656
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural and Biochemical Insight into the Recruitment of Acyl Carrier Protein-Linked Extender Units in Ansamitocin Biosynthesis.
    Zhang F; Ji H; Ali I; Deng Z; Bai L; Zheng J
    Chembiochem; 2020 May; 21(9):1309-1314. PubMed ID: 31777147
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.