BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 31724401)

  • 1. Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase.
    DeColli AA; Zhang X; Heflin KL; Jordan F; Freel Meyers CL
    Biochemistry; 2019 Dec; 58(49):4970-4982. PubMed ID: 31724401
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.
    Zhou J; Yang L; DeColli A; Freel Meyers C; Nemeria NS; Jordan F
    Proc Natl Acad Sci U S A; 2017 Aug; 114(35):9355-9360. PubMed ID: 28808005
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Defining critical residues for substrate binding to 1-deoxy-D-xylulose 5-phosphate synthase--active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate.
    Basta LAB; Patel H; Kakalis L; Jordan F; Meyers CLF
    FEBS J; 2014 Jun; 281(12):2820-2837. PubMed ID: 24767541
    [TBL] [Abstract][Full Text] [Related]  

  • 4. X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.
    Chen PY; DeColli AA; Freel Meyers CL; Drennan CL
    J Biol Chem; 2019 Aug; 294(33):12405-12414. PubMed ID: 31239351
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria.
    DeColli AA; Nemeria NS; Majumdar A; Gerfen GJ; Jordan F; Freel Meyers CL
    J Biol Chem; 2018 Jul; 293(28):10857-10869. PubMed ID: 29784878
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase.
    Toci EM; Austin SL; Majumdar A; Woodcock HL; Freel Meyers CL
    Biochemistry; 2024 Mar; 63(5):671-687. PubMed ID: 38393327
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.
    Sanders S; Vierling RJ; Bartee D; DeColli AA; Harrison MJ; Aklinski JL; Koppisch AT; Freel Meyers CL
    ACS Infect Dis; 2017 Jul; 3(7):467-478. PubMed ID: 28636325
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate.
    Patel H; Nemeria NS; Brammer LA; Freel Meyers CL; Jordan F
    J Am Chem Soc; 2012 Nov; 134(44):18374-9. PubMed ID: 23072514
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism.
    Bartee D; Freel Meyers CL
    Acc Chem Res; 2018 Oct; 51(10):2546-2555. PubMed ID: 30203647
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting the Unique Mechanism of Bacterial 1-Deoxy-d-xylulose-5-phosphate Synthase.
    Bartee D; Freel Meyers CL
    Biochemistry; 2018 Jul; 57(29):4349-4356. PubMed ID: 29944345
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.
    Sprenger GA; Schörken U; Wiegert T; Grolle S; de Graaf AA; Taylor SV; Begley TP; Bringer-Meyer S; Sahm H
    Proc Natl Acad Sci U S A; 1997 Nov; 94(24):12857-62. PubMed ID: 9371765
    [TBL] [Abstract][Full Text] [Related]  

  • 12. DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.
    Morris F; Vierling R; Boucher L; Bosch J; Freel Meyers CL
    Chembiochem; 2013 Jul; 14(11):1309-15. PubMed ID: 23824585
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanistic studies with 2-C-methyl-D-erythritol 4-phosphate synthase from Escherichia coli.
    Fox DT; Poulter CD
    Biochemistry; 2005 Jun; 44(23):8360-8. PubMed ID: 15938625
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 1-Deoxy-D-xylulose 5-phosphate synthase catalyzes a novel random sequential mechanism.
    Brammer LA; Smith JM; Wade H; Meyers CF
    J Biol Chem; 2011 Oct; 286(42):36522-31. PubMed ID: 21878632
    [TBL] [Abstract][Full Text] [Related]  

  • 15. DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group.
    Kholodar SA; Murkin AS
    Biochemistry; 2013 Apr; 52(13):2302-8. PubMed ID: 23473304
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa.
    Altincicek B; Hintz M; Sanderbrand S; Wiesner J; Beck E; Jomaa H
    FEMS Microbiol Lett; 2000 Sep; 190(2):329-33. PubMed ID: 11034300
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase.
    Bartee D; Morris F; Al-Khouja A; Freel Meyers CL
    Chembiochem; 2015 Aug; 16(12):1771-81. PubMed ID: 26174207
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antibacterial Target DXP Synthase Catalyzes the Cleavage of d-Xylulose 5-Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction.
    Johnston ML; Bonett EM; DeColli AA; Freel Meyers CL
    Biochemistry; 2022 Sep; 61(17):1810-1823. PubMed ID: 35998648
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rapid and flexible synthesis of 1-deoxy-D-xylulose-5-phosphate, the substrate for 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Cox RJ; de Andrés-Gómez A; Godfrey CR
    Org Biomol Chem; 2003 Sep; 1(18):3173-7. PubMed ID: 14527148
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents.
    Bartee D; Sanders S; Phillips PD; Harrison MJ; Koppisch AT; Freel Meyers CL
    ACS Infect Dis; 2019 Mar; 5(3):406-417. PubMed ID: 30614674
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.