247 related articles for article (PubMed ID: 31744223)
1. The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT.
Karaś K; Sałkowska A; Karwaciak I; Walczak-Drzewiecka A; Dastych J; Bachorz RA; Ratajewski M
Int J Mol Sci; 2019 Nov; 20(22):. PubMed ID: 31744223
[TBL] [Abstract][Full Text] [Related]
2. The cardenolides strophanthidin, digoxigenin and dihydroouabain act as activators of the human RORγ/RORγT receptors.
Karaś K; Sałkowska A; Walczak-Drzewiecka A; Ryba K; Dastych J; Bachorz RA; Ratajewski M
Toxicol Lett; 2018 Oct; 295():314-324. PubMed ID: 29981919
[TBL] [Abstract][Full Text] [Related]
3. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
Guendisch U; Weiss J; Ecoeur F; Riker JC; Kaupmann K; Kallen J; Hintermann S; Orain D; Dawson J; Billich A; Guntermann C
PLoS One; 2017; 12(11):e0188391. PubMed ID: 29155882
[TBL] [Abstract][Full Text] [Related]
4. Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses.
Ecoeur F; Weiss J; Kaupmann K; Hintermann S; Orain D; Guntermann C
Front Immunol; 2019; 10():577. PubMed ID: 30972071
[TBL] [Abstract][Full Text] [Related]
5. Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity.
Pastwińska J; Karaś K; Sałkowska A; Karwaciak I; Chałaśkiewicz K; Wojtczak BA; Bachorz RA; Ratajewski M
Int J Mol Sci; 2022 Feb; 23(3):. PubMed ID: 35163824
[TBL] [Abstract][Full Text] [Related]
6. 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt.
Lao C; Zhou X; Chen H; Wei F; Huang Z; Bai C
Bioorg Chem; 2019 Sep; 90():103077. PubMed ID: 31323598
[TBL] [Abstract][Full Text] [Related]
7. Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
Huh JR; Littman DR
Eur J Immunol; 2012 Sep; 42(9):2232-7. PubMed ID: 22949321
[TBL] [Abstract][Full Text] [Related]
8. Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation.
Ding Q; Zhao M; Yu B; Bai C; Huang Z
PLoS One; 2015; 10(9):e0137711. PubMed ID: 26368822
[TBL] [Abstract][Full Text] [Related]
9. The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis.
Ruan Q; Kameswaran V; Zhang Y; Zheng S; Sun J; Wang J; DeVirgiliis J; Liou HC; Beg AA; Chen YH
J Exp Med; 2011 Oct; 208(11):2321-33. PubMed ID: 22006976
[TBL] [Abstract][Full Text] [Related]
10. The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation.
Lin YC; Lin YC; Wu CC; Huang MY; Tsai WC; Hung CH; Kuo PL
Oncotarget; 2017 Jan; 8(5):7559-7571. PubMed ID: 27926504
[TBL] [Abstract][Full Text] [Related]
11. Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ.
Olsson RI; Xue Y; von Berg S; Aagaard A; McPheat J; Hansson EL; Bernström J; Hansson P; Jirholt J; Grindebacke H; Leffler A; Chen R; Xiong Y; Ge H; Hansson TG; Narjes F
ChemMedChem; 2016 Jan; 11(2):207-16. PubMed ID: 26553345
[TBL] [Abstract][Full Text] [Related]
12. Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor γ is therapeutic in the collagen-induced arthritis experimental model.
Chang MR; Lyda B; Kamenecka TM; Griffin PR
Arthritis Rheumatol; 2014 Mar; 66(3):579-88. PubMed ID: 24574218
[TBL] [Abstract][Full Text] [Related]
13. The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes.
Jetten AM; Kurebayashi S; Ueda E
Prog Nucleic Acid Res Mol Biol; 2001; 69():205-47. PubMed ID: 11550795
[TBL] [Abstract][Full Text] [Related]
14. Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.
Tanaka S; Suto A; Iwamoto T; Kashiwakuma D; Kagami S; Suzuki K; Takatori H; Tamachi T; Hirose K; Onodera A; Suzuki J; Ohara O; Yamashita M; Nakayama T; Nakajima H
J Exp Med; 2014 Aug; 211(9):1857-74. PubMed ID: 25073789
[TBL] [Abstract][Full Text] [Related]
15. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.
Soroosh P; Wu J; Xue X; Song J; Sutton SW; Sablad M; Yu J; Nelen MI; Liu X; Castro G; Luna R; Crawford S; Banie H; Dandridge RA; Deng X; Bittner A; Kuei C; Tootoonchi M; Rozenkrants N; Herman K; Gao J; Yang XV; Sachen K; Ngo K; Fung-Leung WP; Nguyen S; de Leon-Tabaldo A; Blevitt J; Zhang Y; Cummings MD; Rao T; Mani NS; Liu C; McKinnon M; Milla ME; Fourie AM; Sun S
Proc Natl Acad Sci U S A; 2014 Aug; 111(33):12163-8. PubMed ID: 25092323
[TBL] [Abstract][Full Text] [Related]
16. Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation.
Zhang Y; Xue X; Jin X; Song Y; Li J; Luo X; Song M; Yan W; Song H; Xu Y
Eur J Med Chem; 2014 May; 78():431-41. PubMed ID: 24704616
[TBL] [Abstract][Full Text] [Related]
17. 1,5-Disubstituted Acylated 2-Amino-4,5-dihydroimidazoles as a New Class of Retinoic Acid Receptor-Related Orphan Receptor (ROR) Inhibitors.
Ortiz MA; Piedrafita FJ; Nefzi A
Int J Mol Sci; 2022 Apr; 23(8):. PubMed ID: 35457251
[TBL] [Abstract][Full Text] [Related]
18. A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol).
Wang Y; Kumar N; Crumbley C; Griffin PR; Burris TP
Biochim Biophys Acta; 2010 Aug; 1801(8):917-23. PubMed ID: 20211758
[TBL] [Abstract][Full Text] [Related]
19. Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534.
Xue X; De Leon-Tabaldo A; Luna-Roman R; Castro G; Albers M; Schoetens F; DePrimo S; Devineni D; Wilde T; Goldberg S; Kinzel O; Hoffmann T; Fourie AM; Thurmond RL
Sci Rep; 2021 May; 11(1):11066. PubMed ID: 34040108
[TBL] [Abstract][Full Text] [Related]
20. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Xiao S; Yosef N; Yang J; Wang Y; Zhou L; Zhu C; Wu C; Baloglu E; Schmidt D; Ramesh R; Lobera M; Sundrud MS; Tsai PY; Xiang Z; Wang J; Xu Y; Lin X; Kretschmer K; Rahl PB; Young RA; Zhong Z; Hafler DA; Regev A; Ghosh S; Marson A; Kuchroo VK
Immunity; 2014 Apr; 40(4):477-89. PubMed ID: 24745332
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]