BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

236 related articles for article (PubMed ID: 31751536)

  • 1. Phenotypic-screening generates active novel fetal globin-inducers that downregulate Bcl11a in a monkey model.
    Makino T; Haruyama M; Katayama K; Terashima H; Tsunemi T; Miyazaki K; Terakawa M; Yamashiro K; Yoshioka R; Maeda H
    Biochem Pharmacol; 2020 Jan; 171():113717. PubMed ID: 31751536
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Acyclovir induces fetal hemoglobin via downregulation of γ-globin repressors, BCL11A and SOX6 trans-acting factors.
    Ali H; Khan F; Ghulam Musharraf S
    Biochem Pharmacol; 2021 Aug; 190():114612. PubMed ID: 34010599
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia.
    Bao X; Zhang X; Wang L; Wang Z; Huang J; Zhang Q; Ye Y; Liu Y; Chen D; Zuo Y; Liu Q; Xu P; Huang B; Fang J; Lao J; Feng X; Li Y; Kurita R; Nakamura Y; Yu W; Ju C; Huang C; Mohandas N; Li D; Zhao C; Xu X
    Am J Hum Genet; 2021 Apr; 108(4):709-721. PubMed ID: 33735615
    [TBL] [Abstract][Full Text] [Related]  

  • 4. BCL11A-targeted γ-globin gene induction by triterpenoid glycosides of Fagonia indica: A preclinical scientific validation of indigenous herb for the treatment of β-hemoglobinopathies.
    Iftikhar F; Khan MBN; Tehreem S; Kanwal N; Musharraf SG
    Bioorg Chem; 2023 Nov; 140():106768. PubMed ID: 37586133
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts.
    Wilber A; Tschulena U; Hargrove PW; Kim YS; Persons DA; Barbas CF; Nienhuis AW
    Blood; 2010 Apr; 115(15):3033-41. PubMed ID: 20190190
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies.
    Peterson KR; Costa FC; Fedosyuk H; Neades RY; Chazelle AM; Zelenchuk L; Fonteles AH; Dalal P; Roy A; Chaguturu R; Li B; Pace BS
    PLoS One; 2014; 9(9):e107006. PubMed ID: 25225870
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat β-hemoglobinopathies.
    Liu B; Brendel C; Vinjamur DS; Zhou Y; Harris C; McGuinness M; Manis JP; Bauer DE; Xu H; Williams DA
    Mol Ther; 2022 Aug; 30(8):2693-2708. PubMed ID: 35526095
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
    Sankaran VG; Menne TF; Xu J; Akie TE; Lettre G; Van Handel B; Mikkola HK; Hirschhorn JN; Cantor AB; Orkin SH
    Science; 2008 Dec; 322(5909):1839-42. PubMed ID: 19056937
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters.
    Breveglieri G; Salvatori F; Finotti A; Cosenza LC; Zuccato C; Bianchi N; Breda L; Rivella S; Bresciani A; Bisbocci M; Borgatti M; Gambari R
    Anal Bioanal Chem; 2019 Nov; 411(29):7669-7680. PubMed ID: 31273412
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Featured Article: Modulation of fetal hemoglobin in hereditary persistence of fetal hemoglobin deletion type-2, compared to Sicilian δβ-thalassemia, by BCL11A and SOX6-targeting microRNAs.
    Fornari TA; Lanaro C; Albuquerque DM; Ferreira R; Costa FF
    Exp Biol Med (Maywood); 2017 Feb; 242(3):267-274. PubMed ID: 27591578
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Plastrum testudinis induces γ-globin gene expression through epigenetic histone modifications within the γ-globin gene promoter via activation of the p38 MAPK signaling pathway.
    Qian X; Chen J; Zhao D; Guo L; Qian X
    Int J Mol Med; 2013 Jun; 31(6):1418-28. PubMed ID: 23588991
    [TBL] [Abstract][Full Text] [Related]  

  • 12. SIRT1 activates the expression of fetal hemoglobin genes.
    Dai Y; Chen T; Ijaz H; Cho EH; Steinberg MH
    Am J Hematol; 2017 Nov; 92(11):1177-1186. PubMed ID: 28776729
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Tenofovir disoproxil fumarate-mediated γ-globin induction is correlated with the suppression of trans-acting factors in CD34
    Khan F; Ali H; Musharraf SG
    Eur J Pharmacol; 2022 Jul; 927():175036. PubMed ID: 35618038
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts.
    Khandros E; Huang P; Peslak SA; Sharma M; Abdulmalik O; Giardine BM; Zhang Z; Keller CA; Hardison RC; Blobel GA
    Blood; 2020 May; 135(22):1957-1968. PubMed ID: 32268371
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
    Masuda T; Wang X; Maeda M; Canver MC; Sher F; Funnell AP; Fisher C; Suciu M; Martyn GE; Norton LJ; Zhu C; Kurita R; Nakamura Y; Xu J; Higgs DR; Crossley M; Bauer DE; Orkin SH; Kharchenko PV; Maeda T
    Science; 2016 Jan; 351(6270):285-9. PubMed ID: 26816381
    [TBL] [Abstract][Full Text] [Related]  

  • 16. C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies.
    Zhang X; Xia F; Zhang X; Blumenthal RM; Cheng X
    J Mol Biol; 2024 Apr; 436(7):168343. PubMed ID: 37924864
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.
    Zein S; Li W; Ramakrishnan V; Lou TF; Sivanand S; Mackie A; Pace B
    Exp Biol Med (Maywood); 2010 Nov; 235(11):1385-94. PubMed ID: 20975082
    [TBL] [Abstract][Full Text] [Related]  

  • 18. miR-30a regulates γ-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11A.
    Gholampour MA; Asadi M; Naderi M; Azarkeivan A; Soleimani M; Atashi A
    Mol Biol Rep; 2020 May; 47(5):3909-3918. PubMed ID: 32406020
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells.
    Lan X; Khandros E; Huang P; Peslak SA; Bhardwaj SK; Grevet JD; Abdulmalik O; Wang H; Keller CA; Giardine B; Baeza J; Duffner ER; El Demerdash O; Wu XS; Vakoc CR; Garcia BA; Hardison RC; Shi J; Blobel GA
    Blood Adv; 2019 May; 3(10):1586-1597. PubMed ID: 31126914
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells.
    Macari ER; Schaeffer EK; West RJ; Lowrey CH
    Blood; 2013 Jan; 121(5):830-9. PubMed ID: 23223429
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.