BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

128 related articles for article (PubMed ID: 31755711)

  • 1. Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.
    Sinha N; Karche NP; Verma MK; Walunj SS; Nigade PB; Jana G; Kurhade SP; Hajare AK; Tilekar AR; Jadhav GR; Thube BR; Shaikh JS; Balgude S; Singh LB; Mahimane V; Adurkar SK; Hatnapure G; Raje F; Bhosale Y; Bhanage D; Sachchidanand S; Dixit R; Gupta R; Bokare AM; Dandekar M; Bharne A; Chatterjee M; Desai S; Koul S; Modi D; Mehta M; Patil V; Singh M; Gundu J; Goel RN; Shah C; Sharma S; Bakhle D; Kamboj RK; Palle VP
    J Med Chem; 2020 Feb; 63(3):944-960. PubMed ID: 31755711
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
    Wishka DG; Walker DP; Yates KM; Reitz SC; Jia S; Myers JK; Olson KL; Jacobsen EJ; Wolfe ML; Groppi VE; Hanchar AJ; Thornburgh BA; Cortes-Burgos LA; Wong EH; Staton BA; Raub TJ; Higdon NR; Wall TM; Hurst RS; Walters RR; Hoffmann WE; Hajos M; Franklin S; Carey G; Gold LH; Cook KK; Sands SB; Zhao SX; Soglia JR; Kalgutkar AS; Arneric SP; Rogers BN
    J Med Chem; 2006 Jul; 49(14):4425-36. PubMed ID: 16821801
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacological Characterization of the Novel and Selective
    Wang X; Daley C; Gakhar V; Lange HS; Vardigan JD; Pearson M; Zhou X; Warren L; Miller CO; Belden M; Harvey AJ; Grishin AA; Coles CJ; O'Connor SM; Thomson F; Duffy JL; Bell IM; Uslaner JM
    J Pharmacol Exp Ther; 2020 May; 373(2):311-324. PubMed ID: 32094294
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).
    Zanaletti R; Bettinetti L; Castaldo C; Cocconcelli G; Comery T; Dunlop J; Gaviraghi G; Ghiron C; Haydar SN; Jow F; Maccari L; Micco I; Nencini A; Scali C; Turlizzi E; Valacchi M
    J Med Chem; 2012 May; 55(10):4806-23. PubMed ID: 22468936
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors.
    Arunrungvichian K; Boonyarat C; Fokin VV; Taylor P; Vajragupta O
    ACS Chem Neurosci; 2015 Aug; 6(8):1331-40. PubMed ID: 25978789
    [TBL] [Abstract][Full Text] [Related]  

  • 6. LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization.
    Verma MK; Goel RN; Bokare AM; Dandekar MP; Koul S; Desai S; Tota S; Singh N; Nigade PB; Patil VB; Modi D; Mehta M; Gundu J; Walunj SS; Karche NP; Sinha N; Kamboj RK; Palle VP
    Eur J Pharmacol; 2021 Jan; 891():173685. PubMed ID: 33127363
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model.
    Sun LL; Yang TY; Wei NN; Lu W; Jiao WX; Zhou QQ; Miao YZ; Gao Q; Wang XT; Sun Q; Wang K
    Acta Pharmacol Sin; 2019 Jun; 40(6):737-745. PubMed ID: 30333556
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine receptor: an in silico study.
    Targowska-Duda KM; Kaczor AA; Jozwiak K; Arias HR
    J Biomol Struct Dyn; 2019 Feb; 37(2):411-439. PubMed ID: 29363414
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
    Faghih R; Gopalakrishnan SM; Gronlien JH; Malysz J; Briggs CA; Wetterstrand C; Ween H; Curtis MP; Sarris KA; Gfesser GA; El-Kouhen R; Robb HM; Radek RJ; Marsh KC; Bunnelle WH; Gopalakrishnan M
    J Med Chem; 2009 May; 52(10):3377-84. PubMed ID: 19419141
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.
    Ledneczki I; Tapolcsányi P; Gábor E; Visegrády A; Vass M; Éles J; Holm P; Horváth A; Pocsai A; Mahó S; Greiner I; Krámos B; Béni Z; Kóti J; Káncz AE; Thán M; Kolok S; Laszy J; Balázs O; Bugovits G; Nagy J; Vastag M; Szájli Á; Bozó É; Lévay G; Lendvai B; Némethy Z
    Eur J Med Chem; 2021 Mar; 214():113189. PubMed ID: 33540354
    [TBL] [Abstract][Full Text] [Related]  

  • 11. (R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties.
    Tatsumi R; Fujio M; Takanashi S; Numata A; Katayama J; Satoh H; Shiigi Y; Maeda J; Kuriyama M; Horikawa T; Murozono T; Hashimoto K; Tanaka H
    J Med Chem; 2006 Jul; 49(14):4374-83. PubMed ID: 16821797
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease.
    Bitner RS; Bunnelle WH; Decker MW; Drescher KU; Kohlhaas KL; Markosyan S; Marsh KC; Nikkel AL; Browman K; Radek R; Anderson DJ; Buccafusco J; Gopalakrishnan M
    J Pharmacol Exp Ther; 2010 Sep; 334(3):875-86. PubMed ID: 20504913
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia.
    Beinat C; Banister SD; Herrera M; Law V; Kassiou M
    CNS Drugs; 2015 Jul; 29(7):529-42. PubMed ID: 26242477
    [TBL] [Abstract][Full Text] [Related]  

  • 14. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
    Prickaerts J; van Goethem NP; Chesworth R; Shapiro G; Boess FG; Methfessel C; Reneerkens OA; Flood DG; Hilt D; Gawryl M; Bertrand S; Bertrand D; König G
    Neuropharmacology; 2012 Feb; 62(2):1099-110. PubMed ID: 22085888
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
    Potasiewicz A; Kos T; Ravazzini F; Puia G; Arias HR; Popik P; Nikiforuk A
    Br J Pharmacol; 2015 Nov; 172(21):5123-35. PubMed ID: 26276349
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.
    Malysz J; Grønlien JH; Anderson DJ; Håkerud M; Thorin-Hagene K; Ween H; Wetterstrand C; Briggs CA; Faghih R; Bunnelle WH; Gopalakrishnan M
    J Pharmacol Exp Ther; 2009 Jul; 330(1):257-67. PubMed ID: 19389923
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.
    Gill-Thind JK; Dhankher P; D'Oyley JM; Sheppard TD; Millar NS
    J Biol Chem; 2015 Feb; 290(6):3552-62. PubMed ID: 25516597
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tropisetron sensitizes α7 containing nicotinic receptors to low levels of acetylcholine in vitro and improves memory-related task performance in young and aged animals.
    Callahan PM; Bertrand D; Bertrand S; Plagenhoef MR; Terry AV
    Neuropharmacology; 2017 May; 117():422-433. PubMed ID: 28259598
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats.
    Potasiewicz A; Krawczyk M; Gzielo K; Popik P; Nikiforuk A
    Behav Brain Res; 2020 May; 385():112547. PubMed ID: 32087183
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.
    Tang JS; Xie BX; Bian XL; Xue Y; Wei NN; Zhou JH; Hao YC; Li G; Zhang LR; Wang KW
    Acta Pharmacol Sin; 2015 Jul; 36(7):800-12. PubMed ID: 25948478
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.