BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

165 related articles for article (PubMed ID: 31761657)

  • 1. Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues.
    Wen J; Teske KA; Kyle Hadden M
    Bioorg Med Chem Lett; 2020 Jan; 30(2):126794. PubMed ID: 31761657
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors.
    Pace JR; Teske KA; Chau LQ; Dash RC; Zaino AM; Wechsler-Reya RJ; Hadden MK
    J Med Chem; 2019 Apr; 62(8):3873-3885. PubMed ID: 30896941
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.
    Teske KA; Dash RC; Morel SR; Chau LQ; Wechsler-Reya RJ; Hadden MK
    Eur J Med Chem; 2019 Feb; 163():320-332. PubMed ID: 30529635
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling.
    Shi W; Nacev BA; Aftab BT; Head S; Rudin CM; Liu JO
    J Med Chem; 2011 Oct; 54(20):7363-74. PubMed ID: 21936514
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic.
    Pace JR; DeBerardinis AM; Sail V; Tacheva-Grigorova SK; Chan KA; Tran R; Raccuia DS; Wechsler-Reya RJ; Hadden MK
    J Med Chem; 2016 Apr; 59(8):3635-49. PubMed ID: 27014922
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Introduction of fluorine to phenyl group of 4-(2-pyrimidinylamino)benzamides leading to a series of potent hedgehog signaling pathway inhibitors.
    Xin M; Zhang L; Wen J; Shen H; Zhao X; Jin Q; Tang F
    Bioorg Med Chem Lett; 2017 Aug; 27(15):3259-3263. PubMed ID: 28642101
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and evaluation of vitamin D3 analogues with C-11 modifications as inhibitors of Hedgehog signaling.
    Maschinot CA; Hadden MK
    Bioorg Med Chem Lett; 2017 Sep; 27(17):4011-4014. PubMed ID: 28780161
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.
    You M; Varona-Santos J; Singh S; Robbins DJ; Savaraj N; Nguyen DM
    J Thorac Cardiovasc Surg; 2014 Jan; 147(1):508-16. PubMed ID: 24094913
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.
    Chen B; Trang V; Lee A; Williams NS; Wilson AN; Epstein EH; Tang JY; Kim J
    Mol Cancer Ther; 2016 May; 15(5):866-76. PubMed ID: 26823493
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Formulation and evaluation of itraconazole liposomes for Hedgehog pathway inhibition.
    Pace JR; Jog R; Burgess DJ; Hadden MK
    J Liposome Res; 2020 Sep; 30(3):305-311. PubMed ID: 31576768
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
    Kim J; Tang JY; Gong R; Kim J; Lee JJ; Clemons KV; Chong CR; Chang KS; Fereshteh M; Gardner D; Reya T; Liu JO; Epstein EH; Stevens DA; Beachy PA
    Cancer Cell; 2010 Apr; 17(4):388-99. PubMed ID: 20385363
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.
    Büttner A; Seifert K; Cottin T; Sarli V; Tzagkaroulaki L; Scholz S; Giannis A
    Bioorg Med Chem; 2009 Jul; 17(14):4943-54. PubMed ID: 19541490
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.
    Maschinot CA; Chau LQ; Wechsler-Reya RJ; Hadden MK
    Eur J Med Chem; 2019 Jan; 162():495-506. PubMed ID: 30471551
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Triazoles bind the C-terminal domain of SMO: Illustration by docking and molecular dynamics simulations the binding between SMO and triazoles.
    Liu M; Liang G; Zheng H; Zheng N; Ge H; Liu W
    Life Sci; 2019 Jan; 217():222-228. PubMed ID: 30543826
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-activity relationships for vitamin D3-based aromatic a-ring analogues as hedgehog pathway inhibitors.
    Deberardinis AM; Madden DJ; Banerjee U; Sail V; Raccuia DS; De Carlo D; Lemieux SM; Meares A; Hadden MK
    J Med Chem; 2014 May; 57(9):3724-36. PubMed ID: 24730984
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel 4-(2-pyrimidinylamino)benzamide derivatives as potent hedgehog signaling pathway inhibitors.
    Xin M; Zhang L; Tu C; Tang F; Wen J
    Bioorg Med Chem; 2018 Oct; 26(18):5029-5036. PubMed ID: 30249494
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-like Properties.
    Wen J; Chennamadhavuni D; Morel SR; Hadden MK
    ACS Med Chem Lett; 2019 Sep; 10(9):1290-1295. PubMed ID: 31531199
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways.
    Liang G; Liu M; Wang Q; Shen Y; Mei H; Li D; Liu W
    Oncotarget; 2017 Apr; 8(17):28510-28525. PubMed ID: 28212537
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells.
    Hu Q; Hou YC; Huang J; Fang JY; Xiong H
    J Exp Clin Cancer Res; 2017 Apr; 36(1):50. PubMed ID: 28399898
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-Activity Relationship Studies of Vitamin D3 Analogues Containing an Ether or Thioether Linker as Hedgehog Pathway Inhibitors.
    Wen J; Hadden MK
    ChemMedChem; 2018 Apr; 13(7):748-753. PubMed ID: 29409113
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.