188 related articles for article (PubMed ID: 31767265)
1. Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.
Poudel YB; Rao C; Kotapati S; Deshpande M; Thevanayagam L; Pan C; Cardarelli J; Chowdari N; Kaspady M; Samikannu R; Kuppusamy P; Saravanakumar P; Arunachalam PN; Deshpande S; Rangan V; Rampulla R; Mathur A; Vite GD; Gangwar S
Bioorg Med Chem Lett; 2020 Jan; 30(1):126782. PubMed ID: 31767265
[TBL] [Abstract][Full Text] [Related]
2. Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy.
Chowdari NS; Pan C; Rao C; Langley DR; Sivaprakasam P; Sufi B; Derwin D; Wang Y; Kwok E; Passmore D; Rangan VS; Deshpande S; Cardarelli P; Vite G; Gangwar S
Bioorg Med Chem Lett; 2019 Feb; 29(3):466-470. PubMed ID: 30579797
[TBL] [Abstract][Full Text] [Related]
3. Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.
Nicolaou KC; Rigol S; Pitsinos EN; Das D; Lu Y; Rout S; Schammel AW; Holte D; Lin B; Gu C; Sarvaiya H; Trinidad J; Barbour N; Valdiosera AM; Sandoval J; Lee C; Aujay M; Fernando H; Dhar A; Karsunky H; Taylor N; Pysz M; Gavrilyuk J
Proc Natl Acad Sci U S A; 2021 Jun; 118(25):. PubMed ID: 34155147
[TBL] [Abstract][Full Text] [Related]
4. Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations.
Nicolaou KC; Wang Y; Lu M; Mandal D; Pattanayak MR; Yu R; Shah AA; Chen JS; Zhang H; Crawford JJ; Pasunoori L; Poudel YB; Chowdari NS; Pan C; Nazeer A; Gangwar S; Vite G; Pitsinos EN
J Am Chem Soc; 2016 Jul; 138(26):8235-46. PubMed ID: 27266267
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.
Nicolaou KC; Li R; Chen Q; Lu Z; Pitsinos EN; Schammel A; Lin B; Gu C; Sarvaiya H; Tchelepi R; Valdiosera A; Clubb J; Barbour N; Sisodiya V; Sandoval J; Lee C; Aujay M; Gavrilyuk J
J Am Chem Soc; 2020 Jul; 142(29):12890-12899. PubMed ID: 32662641
[TBL] [Abstract][Full Text] [Related]
6. Total Synthesis in Search of Potent Antibody-Drug Conjugate Payloads. From the Fundamentals to the Translational.
Nicolaou KC; Rigol S
Acc Chem Res; 2019 Jan; 52(1):127-139. PubMed ID: 30575399
[TBL] [Abstract][Full Text] [Related]
7. [Novel Chemical Linkers for Next-generation Antibody-drug Conjugates(ADCs)].
Tsuchikama K
Yakugaku Zasshi; 2019; 139(2):209-219. PubMed ID: 30713230
[TBL] [Abstract][Full Text] [Related]
8. Effect of attachment site on stability of cleavable antibody drug conjugates.
Dorywalska M; Strop P; Melton-Witt JA; Hasa-Moreno A; Farias SE; Galindo Casas M; Delaria K; Lui V; Poulsen K; Loo C; Krimm S; Bolton G; Moine L; Dushin R; Tran TT; Liu SH; Rickert M; Foletti D; Shelton DL; Pons J; Rajpal A
Bioconjug Chem; 2015 Apr; 26(4):650-9. PubMed ID: 25643134
[TBL] [Abstract][Full Text] [Related]
9. Uncialamycin, a new enediyne antibiotic.
Davies J; Wang H; Taylor T; Warabi K; Huang XH; Andersen RJ
Org Lett; 2005 Nov; 7(23):5233-6. PubMed ID: 16268546
[TBL] [Abstract][Full Text] [Related]
10. The Chemical Design and Synthesis of Linkers Used in Antibody Drug Conjugates.
Frigerio M; Kyle AF
Curr Top Med Chem; 2017; 17(32):3393-3424. PubMed ID: 29357801
[TBL] [Abstract][Full Text] [Related]
11. Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates.
Burke PJ; Hamilton JZ; Jeffrey SC; Hunter JH; Doronina SO; Okeley NM; Miyamoto JB; Anderson ME; Stone IJ; Ulrich ML; Simmons JK; McKinney EE; Senter PD; Lyon RP
Mol Cancer Ther; 2017 Jan; 16(1):116-123. PubMed ID: 28062707
[TBL] [Abstract][Full Text] [Related]
12. The cryptophycins as potent payloads for antibody drug conjugates.
Verma VA; Pillow TH; DePalatis L; Li G; Phillips GL; Polson AG; Raab HE; Spencer S; Zheng B
Bioorg Med Chem Lett; 2015 Feb; 25(4):864-8. PubMed ID: 25613677
[TBL] [Abstract][Full Text] [Related]
13. Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.
Puthenveetil S; Loganzo F; He H; Dirico K; Green M; Teske J; Musto S; Clark T; Rago B; Koehn F; Veneziale R; Falahaptisheh H; Han X; Barletta F; Lucas J; Subramanyam C; O'Donnell CJ; Tumey LN; Sapra P; Gerber HP; Ma D; Graziani EI
Bioconjug Chem; 2016 Aug; 27(8):1880-8. PubMed ID: 27412791
[TBL] [Abstract][Full Text] [Related]
14. Optimizing Lysosomal Activation of Antibody-Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers.
Salomon PL; Reid EE; Archer KE; Harris L; Maloney EK; Wilhelm AJ; Miller ML; Chari RVJ; Keating TA; Singh R
Mol Pharm; 2019 Dec; 16(12):4817-4825. PubMed ID: 31609629
[TBL] [Abstract][Full Text] [Related]
15. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985.
Elgersma RC; Coumans RG; Huijbregts T; Menge WM; Joosten JA; Spijker HJ; de Groot FM; van der Lee MM; Ubink R; van den Dobbelsteen DJ; Egging DF; Dokter WH; Verheijden GF; Lemmens JM; Timmers CM; Beusker PH
Mol Pharm; 2015 Jun; 12(6):1813-35. PubMed ID: 25635711
[TBL] [Abstract][Full Text] [Related]
16. Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics.
Nicolaou KC; Das D; Lu Y; Rout S; Pitsinos EN; Lyssikatos J; Schammel A; Sandoval J; Hammond M; Aujay M; Gavrilyuk J
J Am Chem Soc; 2020 Feb; 142(5):2549-2561. PubMed ID: 31976660
[TBL] [Abstract][Full Text] [Related]
17. Rapid, High-Yielding Solid-Phase Synthesis of Cathepsin-B Cleavable Linkers for Targeted Cancer Therapeutics.
Pryyma A; Gunasekera S; Lewin J; Perrin DM
Bioconjug Chem; 2020 Dec; 31(12):2685-2690. PubMed ID: 33274932
[TBL] [Abstract][Full Text] [Related]
18. Introducing Glycolinkers for the Functionalization of Cytotoxic Drugs and Applications in Antibody-Drug Conjugation Chemistry.
Ekholm FS; Pynnönen H; Vilkman A; Pitkänen V; Helin J; Saarinen J; Satomaa T
ChemMedChem; 2016 Nov; 11(22):2501-2505. PubMed ID: 27786414
[TBL] [Abstract][Full Text] [Related]
19. Natural products as exquisitely potent cytotoxic payloads for antibody- drug conjugates.
Gromek SM; Balunas MJ
Curr Top Med Chem; 2015; 14(24):2822-34. PubMed ID: 25487009
[TBL] [Abstract][Full Text] [Related]
20. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.
Nicolaou KC; Chen P; Zhu S; Cai Q; Erande RD; Li R; Sun H; Pulukuri KK; Rigol S; Aujay M; Sandoval J; Gavrilyuk J
J Am Chem Soc; 2017 Nov; 139(43):15467-15478. PubMed ID: 29052423
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
