These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
10. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Wood MR; Noetzel MJ; Engers JL; Bollinger KA; Melancon BJ; Tarr JC; Han C; West M; Gregro AR; Lamsal A; Chang S; Ajmera S; Smith E; Chase P; Hodder PS; Bubser M; Jones CK; Hopkins CR; Emmitte KA; Niswender CM; Wood MW; Duggan ME; Conn PJ; Bridges TM; Lindsley CW Bioorg Med Chem Lett; 2016 Jul; 26(13):3029-3033. PubMed ID: 27185330 [TBL] [Abstract][Full Text] [Related]
11. Discovery of a novel, CNS penetrant M Bewley BR; Spearing PK; Weiner RL; Luscombe VB; Zhan X; Chang S; Cho HP; Rodriguez AL; Niswender CM; Conn PJ; Bridges TM; Engers DW; Lindsley CW Bioorg Med Chem Lett; 2017 Sep; 27(18):4274-4279. PubMed ID: 28866269 [TBL] [Abstract][Full Text] [Related]
12. Challenges in the development of an M Wood MR; Noetzel MJ; Poslusney MS; Melancon BJ; Tarr JC; Lamsal A; Chang S; Luscombe VB; Weiner RL; Cho HP; Bubser M; Jones CK; Niswender CM; Wood MW; Engers DW; Brandon NJ; Duggan ME; Conn PJ; Bridges TM; Lindsley CW Bioorg Med Chem Lett; 2017 Jan; 27(2):171-175. PubMed ID: 27939174 [TBL] [Abstract][Full Text] [Related]
13. Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites. Schober DA; Croy CH; Xiao H; Christopoulos A; Felder CC Mol Pharmacol; 2014 Jul; 86(1):116-23. PubMed ID: 24807966 [TBL] [Abstract][Full Text] [Related]
14. Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Le U; Melancon BJ; Bridges TM; Vinson PN; Utley TJ; Lamsal A; Rodriguez AL; Venable D; Sheffler DJ; Jones CK; Blobaum AL; Wood MR; Daniels JS; Conn PJ; Niswender CM; Lindsley CW; Hopkins CR Bioorg Med Chem Lett; 2013 Jan; 23(1):346-50. PubMed ID: 23177787 [TBL] [Abstract][Full Text] [Related]
15. Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M Schubert JW; Harrison ST; Mulhearn J; Gomez R; Tynebor R; Jones K; Bunda J; Hanney B; Wai JM; Cox C; McCauley JA; Sanders JM; Magliaro B; O'Brien J; Pajkovic N; Huszar Agrapides SL; Taylor A; Gotter A; Smith SM; Uslaner J; Browne S; Risso S; Egbertson M ChemMedChem; 2019 May; 14(9):943-951. PubMed ID: 30920765 [TBL] [Abstract][Full Text] [Related]
16. Challenges in the development of an M Tarr JC; Wood MR; Noetzel MJ; Bertron JL; Weiner RL; Rodriguez AL; Lamsal A; Byers FW; Chang S; Cho HP; Jones CK; Niswender CM; Wood MW; Brandon NJ; Duggan ME; Conn PJ; Bridges TM; Lindsley CW Bioorg Med Chem Lett; 2017 Jul; 27(13):2990-2995. PubMed ID: 28522253 [TBL] [Abstract][Full Text] [Related]
17. Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor. Salovich JM; Vinson PN; Sheffler DJ; Lamsal A; Utley TJ; Blobaum AL; Bridges TM; Le U; Jones CK; Wood MR; Daniels JS; Conn PJ; Niswender CM; Lindsley CW; Hopkins CR Bioorg Med Chem Lett; 2012 Aug; 22(15):5084-8. PubMed ID: 22738637 [TBL] [Abstract][Full Text] [Related]
18. Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. Wood MR; Noetzel MJ; Tarr JC; Rodriguez AL; Lamsal A; Chang S; Foster JJ; Smith E; Chase P; Hodder PS; Engers DW; Niswender CM; Brandon NJ; Wood MW; Duggan ME; Conn PJ; Bridges TM; Lindsley CW Bioorg Med Chem Lett; 2016 Sep; 26(17):4282-6. PubMed ID: 27476142 [TBL] [Abstract][Full Text] [Related]
19. Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M Butler CR; Popiolek M; McAllister LA; LaChapelle EA; Kramer M; Beck EM; Mente S; Brodney MA; Brown M; Gilbert A; Helal C; Ogilvie K; Starr J; Uccello D; Grimwood S; Edgerton J; Garst-Orozco J; Kozak R; Lotarski S; Rossi A; Smith D; O'Connor R; Lazzaro J; Steppan C; Steyn SJ J Med Chem; 2024 Jul; 67(13):10831-10847. PubMed ID: 38888621 [TBL] [Abstract][Full Text] [Related]
20. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors. Croy CH; Schober DA; Xiao H; Quets A; Christopoulos A; Felder CC Mol Pharmacol; 2014 Jul; 86(1):106-15. PubMed ID: 24807965 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]