BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

112 related articles for article (PubMed ID: 31787068)

  • 1. Design potential selective inhibitors for human leukocyte common antigen-related (PTP-LAR) with fragment replace approach.
    Wu JW; Zhang H; Li WY; Tang X; Li HL; Lu XH; Zheng ZH; Ma Y; Wang RL
    J Biomol Struct Dyn; 2020 Nov; 38(18):5338-5348. PubMed ID: 31787068
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
    Liu WS; Wang RR; Yue H; Zheng ZH; Lu XH; Wang SQ; Dong WL; Wang RL
    J Biomol Struct Dyn; 2020 Aug; 38(13):3814-3824. PubMed ID: 31490104
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of potential leukocyte antigen-related protein (PTP-LAR) inhibitors through 3D QSAR pharmacophore-based virtual screening and molecular dynamics simulation.
    Du S; Yang B; Wang X; Li WY; Lu XH; Zheng ZH; Ma Y; Wang RL
    J Biomol Struct Dyn; 2020 Sep; 38(14):4232-4245. PubMed ID: 31588870
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions.
    McCullough BS; Batsomboon P; Hutchinson KB; Dudley GB; Barrios AM
    J Nat Prod; 2019 Dec; 82(12):3386-3393. PubMed ID: 31809044
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, biological evaluation and molecular dynamics simulation studies of (R)-5-methylthiazolidin-4-One derivatives as megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) inhibitors for the treatment of type 2 diabetes.
    Wu J; Sun Y; Zhou H; Ma Y; Wang R
    J Biomol Struct Dyn; 2020 Jul; 38(11):3156-3165. PubMed ID: 31402760
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, bioactivity, 3D-QSAR studies of novel dibenzofuran derivatives as PTP-MEG2 inhibitors.
    Ma Y; Wei HY; Zhang YZ; Jin WY; Li HL; Zhou H; Cheng XC; Wang RL
    Oncotarget; 2017 Jun; 8(24):38466-38481. PubMed ID: 28388567
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of novel, less toxic PTP-LAR inhibitors using in silico strategies: pharmacophore modeling, SADMET-based virtual screening and docking.
    Ajay D; Sobhia ME
    J Mol Model; 2012 Jan; 18(1):187-201. PubMed ID: 21523550
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Simplified receptor based pharmacophore approach to retrieve potent PTP-LAR inhibitors using apoenzyme.
    Ajay D; Sobhia ME
    Curr Comput Aided Drug Des; 2011 Sep; 7(3):159-72. PubMed ID: 21726194
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Toward a treatment of diabesity: Rational design, synthesis and biological evaluation of benzene-sulfonamide derivatives as a new class of PTP-1B inhibitors.
    Ghareb N; El-Sayed NM; Abdelhameed R; Yamada K; Elgawish MS
    Bioorg Chem; 2019 May; 86():322-338. PubMed ID: 30743173
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The leukocyte common antigen-related protein LAR: candidate PTP for inhibitory targeting.
    Mooney RA; LeVea CM
    Curr Top Med Chem; 2003; 3(7):809-19. PubMed ID: 12678846
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of the potential dual inhibitor of protein tyrosine phosphatase sigma and leukocyte common antigen-related phosphatase by virtual screen, molecular dynamic simulations and post-analysis.
    Zhou L; Ma YC; Tang X; Li WY; Ma Y; Wang RL
    J Biomol Struct Dyn; 2021 Jan; 39(1):45-62. PubMed ID: 31842717
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.
    Yang JW; He XP; Li C; Gao LX; Sheng L; Xie J; Shi XX; Tang Y; Li J; Chen GR
    Bioorg Med Chem Lett; 2011 Feb; 21(4):1092-6. PubMed ID: 21251827
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of novel N-aryl-ω-(benzoazol-2-yl)-sulfanylalkanamides as dual inhibitors of α-glucosidase and protein tyrosine phosphatase 1B.
    Wang MY; Cheng XC; Chen XB; Li Y; Zang LL; Duan YQ; Chen MZ; Yu P; Sun H; Wang RL
    Chem Biol Drug Des; 2018 Sep; 92(3):1647-1656. PubMed ID: 29745030
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and LAR inhibition of 7-alkoxy analogues of illudalic acid.
    Ling Q; Zhou YY; Cai ZL; Zhang YH; Xiong B; Ma LP; Wang X; Li X; Li J; Shen JK
    Yao Xue Xue Bao; 2010 Nov; 45(11):1385-97. PubMed ID: 21355526
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.
    Rao GS; Ramachandran MV; Bajaj JS
    J Biomol Struct Dyn; 2006 Feb; 23(4):377-84. PubMed ID: 16363874
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Docking Assisted Prediction and Biological Evaluation of Sideritis L. Components with PTP1b Inhibitory Action and Probable Anti-Diabetic Properties.
    Eleftheriou P; Therianou E; Lazari D; Dirnali S; Micha A
    Curr Top Med Chem; 2019; 19(5):383-392. PubMed ID: 30806317
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase.
    Ma Y; Sun SX; Cheng XC; Wang SQ; Dong WL; Wang RL; Xu WR
    Chem Biol Drug Des; 2013 Nov; 82(5):595-602. PubMed ID: 23848232
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel Imbricatolic acid derivatives as protein tyrosine phosphatase-1B inhibitors: Design, synthesis, biological evaluation and molecular docking.
    Khan MF; Azad CS; Kumar A; Saini M; Narula AK; Jain S
    Bioorg Med Chem Lett; 2016 Apr; 26(8):1988-92. PubMed ID: 26965864
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
    Bleasdale JE; Ogg D; Palazuk BJ; Jacob CS; Swanson ML; Wang XY; Thompson DP; Conradi RA; Mathews WR; Laborde AL; Stuchly CW; Heijbel A; Bergdahl K; Bannow CA; Smith CW; Svensson C; Liljebris C; Schostarez HJ; May PD; Stevens FC; Larsen SD
    Biochemistry; 2001 May; 40(19):5642-54. PubMed ID: 11341829
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation.
    Liu WS; Jin WY; Zhou L; Lu XH; Li WY; Ma Y; Wang RL
    J Comput Aided Mol Des; 2019 Aug; 33(8):759-774. PubMed ID: 31300938
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.