These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 31793906)

  • 1. Structural basis for the diversity of the mechanism of nucleotide hydrolysis by the aminoglycoside-2''-phosphotransferases.
    Smith CA; Toth M; Stewart NK; Maltz L; Vakulenko SB
    Acta Crystallogr D Struct Biol; 2019 Dec; 75(Pt 12):1129-1137. PubMed ID: 31793906
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.
    Young PG; Walanj R; Lakshmi V; Byrnes LJ; Metcalf P; Baker EN; Vakulenko SB; Smith CA
    J Bacteriol; 2009 Jul; 191(13):4133-43. PubMed ID: 19429619
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases.
    Shi K; Houston DR; Berghuis AM
    Biochemistry; 2011 Jul; 50(28):6237-44. PubMed ID: 21678960
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis for dual nucleotide selectivity of aminoglycoside 2''-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases.
    Shi K; Berghuis AM
    J Biol Chem; 2012 Apr; 287(16):13094-102. PubMed ID: 22371504
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme.
    Frase H; Toth M; Vakulenko SB
    J Biol Chem; 2012 Dec; 287(52):43262-9. PubMed ID: 23115238
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila.
    Fong DH; Lemke CT; Hwang J; Xiong B; Berghuis AM
    J Biol Chem; 2010 Mar; 285(13):9545-9555. PubMed ID: 20089863
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis.
    Smith CA; Toth M; Weiss TM; Frase H; Vakulenko SB
    Acta Crystallogr D Biol Crystallogr; 2014 Oct; 70(Pt 10):2754-64. PubMed ID: 25286858
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2''-IVa.
    Toth M; Frase H; Antunes NT; Smith CA; Vakulenko SB
    Protein Sci; 2010 Aug; 19(8):1565-76. PubMed ID: 20556826
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bulky "gatekeeper" residue changes the cosubstrate specificity of aminoglycoside 2''-phosphotransferase IIa.
    Bhattacharya M; Toth M; Smith CA; Vakulenko SB
    Antimicrob Agents Chemother; 2013 Aug; 57(8):3763-6. PubMed ID: 23716051
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia.
    Caldwell SJ; Huang Y; Berghuis AM
    Structure; 2016 Jun; 24(6):935-45. PubMed ID: 27161980
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study.
    Kaplan E; Guichou JF; Chaloin L; Kunzelmann S; Leban N; Serpersu EH; Lionne C
    Biochim Biophys Acta; 2016 Apr; 1860(4):802-13. PubMed ID: 26802312
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Aminoglycoside 2''-phosphotransferase IIIa (APH(2'')-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2'' kinases.
    Smith CA; Toth M; Frase H; Byrnes LJ; Vakulenko SB
    J Biol Chem; 2012 Apr; 287(16):12893-903. PubMed ID: 22367198
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus.
    Badarau A; Shi Q; Chow JW; Zajicek J; Mobashery S; Vakulenko S
    J Biol Chem; 2008 Mar; 283(12):7638-47. PubMed ID: 18199745
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia.
    Smith CA; Toth M; Bhattacharya M; Frase H; Vakulenko SB
    Acta Crystallogr D Biol Crystallogr; 2014 Jun; 70(Pt 6):1561-71. PubMed ID: 24914967
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Purification, crystallization and preliminary X-ray analysis of Enterococcus casseliflavus aminoglycoside-2''-phosphotransferase-IVa.
    Toth M; Vakulenko S; Smith CA
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2010 Jan; 66(Pt 1):81-4. PubMed ID: 20057078
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis for the substrate recognition of aminoglycoside 7''-phosphotransferase-Ia from Streptomyces hygroscopicus.
    Takenoya M; Shimamura T; Yamanaka R; Adachi Y; Ito S; Sasaki Y; Nakamura A; Yajima S
    Acta Crystallogr F Struct Biol Commun; 2019 Sep; 75(Pt 9):599-607. PubMed ID: 31475927
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity.
    McKay GA; Thompson PR; Wright GD
    Biochemistry; 1994 Jun; 33(22):6936-44. PubMed ID: 8204627
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aminoglycoside phosphotransferases: proteins, structure, and mechanism.
    Wright GD; Thompson PR
    Front Biosci; 1999 Jan; 4():D9-21. PubMed ID: 9872733
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen.
    Toth M; Frase H; Antunes NT; Vakulenko SB
    Antimicrob Agents Chemother; 2013 Jan; 57(1):452-7. PubMed ID: 23129050
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia.
    Caldwell SJ; Berghuis AM
    Antimicrob Agents Chemother; 2018 Jul; 62(7):. PubMed ID: 29661878
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.